Increased Risk for Depression After Breast Cancer: A Nationwide Population-Based Cohort Study of Associated Factors in Denmark, 1998-2011

Suppli, Nis P.; Johansen, Christoffer; Christensen, Jane; Kessing, Lars Vedel; Kroman, Niels; Dalton, Susanne Oksbjerg

doi:10.1200/jco.2013.54.0419

Cited by 97 publications

(78 citation statements)

References 27 publications

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“…Both increased risk of depression and increased risk of antidepressant use have been reported in patients receiving diagnoses of other life-threatening diseases including breast cancer, although the risk increases were smaller in breast cancer (relative risk 1.7 for depression and 3.1 for antidepressant use). 18 Previous studies rarely examined the temporal pattern of depression prevalence and were mostly based on small numbers of patients (range 27-131). [6][7][8][9][10][11][12][13][19][20][21] A recent meta-analysis identified a total of 3,190 patients with ALS from 103 studies on ALS and depression, 22 whereas in the present study, we were able to enroll 1,752 patients in a single study.…”

Section: Discussionmentioning

confidence: 99%

Depression in amyotrophic lateral sclerosis

et al. 2016

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Objective: To examine the relative risk of depression among patients with amyotrophic lateral sclerosis (ALS), both in terms of depression diagnosis and use of antidepressant drugs, before and after diagnosis. Methods:We conducted a nested case-control study including 1,752 patients with ALS diagnosed from July 2005 to December 2010 and 8,760 controls based on the Swedish national health and population registers, to assess the associations of depression diagnosis and use of antidepressant drugs with a subsequent risk of ALS. We further followed the patients with ALS after diagnosis to estimate the association of an ALS diagnosis with the subsequent risk of depression and use of antidepressant drugs.Results: Before diagnosis, patients with ALS were at higher risk of receiving a clinical diagnosis of depression compared to controls (odds ratio [OR] 1.7, 95% confidence interval [CI] 1.3-2.3), and the highest risk increase was noted during the year before diagnosis (OR 3.5, 95% CI 2.1-5.6). Patients with ALS also had a highly increased risk of depression within the first year after diagnosis (hazard ratio 7.9, 95% CI 4.4-14.3). Antidepressant use was more common in patients with ALS than in controls, especially during the year before (OR 5.8, 95% CI 4.5-7.5) and the year after (hazard ratio 16.1, 95% CI 11.5-22.6) diagnosis. Approximately 30% of patients with amyotrophic lateral sclerosis (ALS) show mild cognitive impairment and 15% present with overt frontotemporal dementia (FTD). Conclusions:1,2 The overlap between ALS and FTD presents a continuum of symptoms such as memory impairment, apathy, and behavioral changes, 3,4 many of which mimic the typical symptoms of depression. 5The strong emotions evoked by receiving a serious diagnosis such as ALS may also lead to increased risk of mental illnesses, including depression. Multiple studies have shown that patients with ALS are more likely to develop depression than ALS-free individuals, although the reported prevalence of depression varies greatly.6-13 Different measurements of depression together with the varying representativeness of the patient samples used in previous studies may partly explain the different prevalences reported so far.The aim of the present study was to investigate the occurrence of depression diagnosis and use of antidepressants before and after ALS diagnosis in a nationwide sample of patients with ALS, using a matched random sample of the Swedish population as the reference.

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Section: Discussionmentioning

confidence: 99%

Depression in amyotrophic lateral sclerosis

et al. 2016

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“…A complex interplay of demographic factors such as age and living alone, psychosocial and disease related distress, as well as immunological aspects may play a role (Bower et al, 2002;Standish et al, 2008;Suppli et al, 2014). Regarding the underlying pathophysiological mechanisms of this association, immune dysregulation seems to be an important factor, since it can lead to an increased risk of breast cancer and is also found in a subset of patients with depression (Maes, 1999;Raison et al, 2006).…”

Section: Introductionmentioning

confidence: 96%

“…Breast cancer is the most common cancer among females, with an annual global incidence of more than 1.6 million cases (IARC, 2012;Suppli et al, 2014), of which an estimated number of 30% develop depression or depressive adaptation disorder within 5 years post diagnosis . A complex interplay of demographic factors such as age and living alone, psychosocial and disease related distress, as well as immunological aspects may play a role (Bower et al, 2002;Standish et al, 2008;Suppli et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Levels in neurotransmitter precursor amino acids correlate with mental health in patients with breast cancer

Hüfner

Oberguggenberger

Kohl

et al. 2015

Psychoneuroendocrinology

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“…Accordingly, another goal was to examine the associated sociodemographic and medical factors that can be easily and routinely assessed in the oncologic setting. We hypothesized that younger age [18,19,[22][23][24][25][26] and markers of socioeconomic disadvantage [18,19,23,24,26] would be associated with depression endpoints and explored other sociodemographic and medical factors [18-20, 23, 24, 27].…”

mentioning

confidence: 99%

Depressive episodes, symptoms, and trajectories in women recently diagnosed with breast cancer

Stanton

Wiley

Krull

et al. 2015

Breast Cancer Res Treat

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Depression carries serious psychosocial, physical, and economic consequences for cancer survivors. Study goals were to characterize patterns and predictors of depressive symptoms and major depressive episodes in recently diagnosed breast cancer patients. Consecutively recruited women (N = 460) completed a validated interview (CIDI) and questionnaire measure (CES-D) of depression within 4 months after invasive breast cancer diagnosis and at six additional assessments across 12 months. Outcomes were major depressive episodes, continuous symptom scores, and latent symptom trajectory classes. Across 12 months, 16.6 % of women met criteria for a major depressive episode. Unemployment predicted depressive episodes after other correlates were controlled. Distinct trajectory classes were apparent: an estimated 38 % of women had chronically elevated symptoms (High trajectory), 20 % recovered from elevated symptoms (Recovery), and 43 % had lower symptoms (Low and Very Low trajectories). Although 96 % of episodes occurred in the High or Recovery classes, 66 % of women in the High trajectory did not have an episode. Women in the Low (vs High) trajectory were more likely to be older, retired, more affluent, and have fewer comorbid diseases and briefer oncologic treatment. Women in the Recovery trajectory (vs High) were more likely to be married and more affluent and have fewer comorbid diseases. Assuming available therapeutic resources, assessment of both depressive symptoms and episodes over several months after diagnosis is important. Identification of patients at risk for persistently high depressive symptoms (e.g., younger, longer treatment course) opens targeted opportunities to prevent and promote rapid recovery from depression.

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Increased Risk for Depression After Breast Cancer: A Nationwide Population-Based Cohort Study of Associated Factors in Denmark, 1998-2011

Cited by 97 publications

References 27 publications

Depression in amyotrophic lateral sclerosis

Depression in amyotrophic lateral sclerosis

Levels in neurotransmitter precursor amino acids correlate with mental health in patients with breast cancer

Depressive episodes, symptoms, and trajectories in women recently diagnosed with breast cancer

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