Increased resting-state brain entropy of parahippocampal gyrus and dorsolateral prefrontal cortex in manic and euthymic adolescent bipolar disorder

Kuang, Liangfeng; Gao, Weijia; Wang, Luoyu; Guo, Yongxin; Cao, Weifang; Cui, Dong; Jiao, Qing; Qiu, Jianfeng; Su, Linyan; Lu, Guangming

doi:10.1016/j.jpsychires.2021.08.025

Cited by 10 publications

(9 citation statements)

References 58 publications

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“…We also found that the mice had more difficulty maintaining attention to complete cognitive tasks during the manic phase in this study. This finding is similar to those from macro-imaging studies of patients with BPD [ 95 – 99 ]. A multiple-arm study is needed to clarify this question.…”

Section: Discussionsupporting

confidence: 89%

Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study

et al. 2021

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Brain pathological features during manic/hypomanic and depressive episodes in the same patients with bipolar disorder (BPD) have not been described precisely. The study aimed to investigate depressive and manic-phase-specific brain neural activity patterns of BPD in the same murine model to provide information guiding investigation of the mechanism of phase switching and tailored prevention and treatment for patients with BPD. In vivo two-photon imaging was used to observe brain activity alterations in the depressive and manic phases in the same murine model of BPD. Two-photon imaging showed significantly reduced Ca2+ activity in temporal cortex pyramidal neurons in the depression phase in mice exposed to chronic unpredictable mild stress (CUMS), but not in the manic phase in mice exposed to CUMS and ketamine. Total integrated calcium values correlated significantly with immobility times. Brain Ca2+ hypoactivity was observed in the depression and manic phases in the same mice exposed to CUMS and ketamine relative to naïve controls. The novel object recognition preference ratio correlated negatively with the immobility time in the depression phase and the total distance traveled in the manic phase. With recognition of its limitations, this study revealed brain neural activity impairment indicating that intrinsic emotional network disturbance is a mechanism of BPD and that brain neural activity is associated with cognitive impairment in the depressive and manic phases of this disorder. These findings are consistent with those from macro-imaging studies of patients with BPD. The observed correlation of brain neural activity with the severity of depressive, but not manic, symptoms need to be investigated further.

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Section: Discussionsupporting

confidence: 89%

Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study

et al. 2021

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“…In addition, an fMRI study revealed that bipolar disorder patients showed increased brain entropy (i.e. randomness of activity) in the right parahippocampal gyrus and left DLPFC (20). Therefore, in our patient as well, the appearance of mania may be related to left BA46 dysfunction.…”

Section: Discussionsupporting

confidence: 51%

Syntactic Impairment Associated with Hypoperfusion in the Left Middle and Inferior Frontal Gyri after Right Cerebellar Hemorrhage

et al. 2023

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Cerebellar injuries can cause syntax impairments. Cortical dysfunction due to cerebello-cerebral diaschisis is assumed to play a role in this phenomenon. Functional magnetic resonance imaging studies have repeatedly shown the activation of Broca's area in response to syntactic tasks. However, there have been no reports of selective syntax impairment and hypoperfusion restricted to this area after cerebellar injury. We herein report a patient with right cerebellar hemorrhage that led to marked syntax impairment along with severe hypoperfusion confined to the Brodmann area (BA) 45 (anterior part of Broca's area) and BA46.

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“…Adult BD-II patients exhibited increased functional connectivity strength and greater resting metabolic rates in the bilateral PHG (31). A recent paper (17) has reported increased BEN in right PHG in manic and euthymic BD adolescents. Taken together, the increased BEN in PHG found in the present study may further illustrate disrupted complexity of BOLD signals of the ventromedial circuit which was related to internal emotional control.…”

Section: Discussionmentioning

confidence: 90%

“…Contrast with other parts of the brain, higher entropy was showed in BD patients and its correlations to neurocognition (14,16). Few studies had used BEN to assess brain signal complexity of BD patients (14,17). Compared to HCs, manic and euthymic adolescent BD (ABD) patients showed increased BEN in the right parahippocampal gyrus (PHG) and left dorsolateral prefrontal lobes, and BEN in the right PHG was associated with the numbers of episode in manic ABD patients.…”

mentioning

confidence: 99%

Immediate Visual Reproduction Negatively Correlates with Brain Entropy of Parahippocampal Gyrus and Inferior Occipital Gyrus in Bipolar II Disorder Adolescents

Liu

Gao

Cao

et al. 2023

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Background Brain entropy reveals complexity and irregularity of brain, and it has been proven to reflect brain complexity alteration in disease states. Previous studies found that bipolar disorder adolescents showed cognitive impairment. The relationship between complexity of brain neural activity and cognition of bipolar II disorder (BD-II) adolescents remains unclear. Methods Nineteen BD-II patients (14.63 ± 1.57 years old) and seventeen age-gender matched healthy controls (HCs) (14.18 ± 1.51 years old) were enlisted. Entropy values of all voxels of the brain in resting-state functional MRI data were calculated and differences of them between BD-II and HCs groups were evaluated. After that, correlation analyses were performed between entropy values of brain regions showing significant entropy differences and clinical indices in BD-II adolescents. Results Significant differences were found in scores of immediate visual reproduction subtest, trail making test and Stroop color-word test between the two groups. Compared with HCs, BD-II adolescents showed significant increased brain entropy in right parahippocampal gyrus and right inferior occipital gyrus. Besides, significant negative correlations between brain entropy values of right parahippocampal gyrus, right inferior occipital gyrus and immediate visual reproduction subtest scores were observed in BD-II adolescents. Conclusions The findings of the present study suggested that the disrupted function of corticolimbic system is related with cognitive abnormality of BD-II adolescents. And from the perspective temporal dynamics of brain system, the current study, brain entropy may provide available evidences for understanding the underlying neural mechanism in BD-II adolescents

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Increased resting-state brain entropy of parahippocampal gyrus and dorsolateral prefrontal cortex in manic and euthymic adolescent bipolar disorder

Cited by 10 publications

References 58 publications

Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study

Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study

Syntactic Impairment Associated with Hypoperfusion in the Left Middle and Inferior Frontal Gyri after Right Cerebellar Hemorrhage

Immediate Visual Reproduction Negatively Correlates with Brain Entropy of Parahippocampal Gyrus and Inferior Occipital Gyrus in Bipolar II Disorder Adolescents

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