Increased responses of the reward circuitry to positive task feedback following acute stress in healthy controls but not in siblings of schizophrenia patients

Leeuwen, Judith M.C. van; Vink, Matthijs; Joëls, Marian; Kahn, René S.; Hermans, Erno J.; Vinkers, Christiaan H.

doi:10.1016/j.neuroimage.2018.09.051

Cited by 26 publications

(20 citation statements)

References 51 publications

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“…The first scan session was followed by the stress or control condition of the TSST. The first post-stress resting state (RS1) was acquired 20 min following TSST onset, followed by an emotion processing task [viewing and rating pictures from the international affective picture system (van Leeuwen et al, 2018 )] and a reward processing task (van Leeuwen et al, 2019 ). The second post-stress resting state scan (RS2) was acquired 90 min following TSST onset.…”

Section: Methodsmentioning

confidence: 99%

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

et al. 2020

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Background An adaptive neural stress response is essential to adequately cope with a changing environment. It was previously argued that sympathetic/noradrenergic activity during acute stress increases salience network (SN) connectivity and reduces executive control network (ECN) connectivity in healthy controls, with opposing effects in the late aftermath of stress. Altered temporal dynamics of these networks in response to stress are thought to play a role in the development of psychopathology in vulnerable individuals. Methods We exposed male healthy controls (n = 40, mean age = 33.9) and unaffected siblings of schizophrenia patients (n = 39, mean age = 33.2) to the stress or control condition of the trier social stress test and subsequently investigated resting state functional connectivity of the SN and ECN directly after and 1.5 h after stress. Results Acute stress resulted in increased functional connectivity within the SN in healthy controls, but not in siblings (group × stress interaction pfwe < 0.05). In the late aftermath of stress, stress reduced functional connectivity within the SN in both groups. Moreover, we found increased functional connectivity between the ECN and the cerebellum in the aftermath of stress in both healthy controls and siblings of schizophrenia patients. Conclusions The results show profound differences between siblings of schizophrenia patients and controls during acute stress. Siblings lacked the upregulation of neural resources necessary to quickly and adequately cope with a stressor. This points to a reduced dynamic range in the sympathetic response, and may constitute a vulnerability factor for the development of psychopathology in this at-risk group.

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Section: Methodsmentioning

confidence: 99%

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

et al. 2020

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“…Here, feedback processing is more strongly driven by stimuli signaling reward and possibly associated with stress-induced cortisol change 43 while learning from negative feedback is decreased, potentially linked to cortisol levels before learning 44 . On the neural systems level, stress recovery is associated with increased striatal responses to rewarding feedback at 50 min after stress 37 , 45 . Moreover, specifically individuals with low striatal reward reactivity showed an association of recent life stress with lower positive affect, which makes striatal reactivity a potential factor of successful stress coping 46 .…”

Section: Introductionmentioning

confidence: 99%

Self-beneficial belief updating as a coping mechanism for stress-induced negative affect

Czekalla

Stierand

Stolz

et al. 2021

Sci Rep

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Being confronted with social-evaluative stress elicits a physiological and a psychological stress response. This calls for regulatory processes to manage negative affect and maintain self-related optimistic beliefs. The aim of the current study was to investigate the affect-regulating potential of self-related updating of ability beliefs after exposure to social-evaluative stress, in comparison to non-social physical stress or no stress. We assessed self-related belief updating using trial-by-trial performance feedback and described the updating behavior in a mechanistic way using computational modeling. We found that social-evaluative stress was accompanied by an increase in cortisol and negative affect which was related to a positive shift in self-related belief updating. This self-beneficial belief updating, which was absent after physical stress or control, was associated with a better recovery from stress-induced negative affect. This indicates that enhanced integration of positive self-related feedback can act as a coping strategy to deal with social-evaluative stress.

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“…The first scan session was followed by the stress or control condition of the TSST. The first post-stress resting state (RS1) was acquired 20 min following TSST onset, followed by an emotion processing task [viewing and rating pictures from the international affective picture system (van Leeuwen et al, 2018)] and a reward processing task (van Leeuwen et al, 2019). The second post-stress resting state scan (RS2) was acquired 90 min following TSST onset.…”

Section: General Procedures and Stress Inductionmentioning

confidence: 99%

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

Leeuwen¹,

Vinkers

Vink

et al. 2019

Psychoneuroendocrinology

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Increased responses of the reward circuitry to positive task feedback following acute stress in healthy controls but not in siblings of schizophrenia patients

Abstract: Increased responses of the reward circuitry to positive task feedback following acute stress in healthy controls but not in siblings of schizophrenia patients

Cited by 26 publications

References 51 publications

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

Self-beneficial belief updating as a coping mechanism for stress-induced negative affect

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

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