Increased Resistin Serum Concentrations in Patients with Type 1 Diabetes Mellitus

Geyikli, İclal; Keskın, Mehmet; Kör, Yılmaz; Akan, Müslüm

doi:10.4274/jcrpe.1072

Cited by 21 publications

(9 citation statements)

References 37 publications

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“…Leptin is known as a key appetite-regulating hormone. Recent studies revealed that leptin has the effect of normalizing hyperglycemia and increasing insulin sensitivity [ 17 ]. The leptin data of patients with T1DM compared with healthy controls are controversial, especially during pubertal development [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Adipokines such as adiponectin, leptin and resistin are bioactive mediators secreted by adipose tissue [ 6 ]. They have a significant role in the regulation of lipid and carbohydrate metabolism and involvement in the inflammatory responses [ 7 ]. In contrast to type 2 diabetes, involvement of adipose tissue in the low-grade systemic inflammation observed in T1DM has been investigated far less.…”

Section: Introductionmentioning

confidence: 99%

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Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus

Ismail¹,

Hamid²,

Ibrahim³

et al. 2017

aoms

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IntroductionAdiponectin, leptin and resistin are adipokines that play important roles in the regulation of lipid and carbohydrate metabolism in type 2 diabetes (T2DM). However, their influence in type 1 diabetes mellitus is still unknown. The aim of this study was to measure serum adiponectin, leptin and resistin levels and to investigate their relationships with vitamin D and other clinical and laboratory parameters in patients with type 1 diabetes.Material and methodsFifty subjects with type 1 diabetes and 50 healthy age- and sex-matched subjects were selected from the Endocrinology Outpatient Clinic of Cairo University Pediatrics Hospital. Enzyme-linked immunosorbent assay was used to measure the levels of leptin, adiponectin and resistin. Vitamin D levels were measured using electro-chemiluminescence immunoassay.ResultsThere were no significant differences in adiponectin and leptin levels between diabetic and control subjects (p = 0.6 and p = 0.5 respectively). Resistin levels were significantly higher in the diabetic group compared to controls (p < 0.001) and in postpubertal patients compared to prepubertal patients (p < 0.04). Serum resistin in type 1 diabetes showed a negative correlation with vitamin D (p < 0.001) and a positive correlation with glycated hemoglobin (HbA1c) (p = 0.006), while other adipokines were not interrelated.ConclusionsThese results strongly support a role of resistin and vitamin D deficiency in the pathophysiology of type 1 diabetes. Vitamin D may be involved in resistin regulation through an unknown mechanism. Further studies are recommended to understand resistin regulation in type 1 diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus

Ismail¹,

Hamid²,

Ibrahim³

et al. 2017

aoms

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“…Although resistin is considered as an adypocytokine, a translational study by Schwartz and Lazar implied that human resistin primarily originates from macrophages, rather than from adipocytes [4]. Increased resistin concentrations are commonly seen in diabetes mellitus, metabolic syndrome, and inflammatory bowel disease [5][6][7], but previous studies have also shown that elevated resistin levels are associated with the increased risk for development of CRC [8]. Resistin is believed to contribute to cancer expansion by stimulating malignant cell growth and proliferation, but the experiments conducted in order to verify this hypothesis yielded contradictory results [9].…”

Section: Introductionmentioning

confidence: 99%

Association among resistin, adenylate cyclase-associated protein 1 and high-density lipoprotein cholesterol in patients with colorectal cancer: a multi-marker approach, as a hallmark of innovative predictive, preventive, and personalized medicine

et al. 2019

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Background Elevated concentrations of resistin have been reported in colorectal cancer (CRC), but its interactions with adenylate cyclase-associated protein 1 (CAP-1) are largely unexplored. We investigated resistin plasma concentration, peripheral blood mononuclear cells (PBMCs) resistin messenger ribonucleic acid (mRNA), and CAP-1 mRNA levels in CRC patients, as well as the impact of resistin gene polymorphism rs1862513 on the examined markers. We also explored associations of resistin with high-density lipoprotein cholesterol (HDL-C) and predictive potential of our parameters for CRC. Methods Eighty-six patients with CRC and 75 healthy adults were included. Commercial ELISA kit was used for obtaining resistin's concentrations, while polymerase chain reaction (PCR) method was applied for evaluation of resistin and CAP-1 mRNA levels and rs1862513 polymorphism. Results Plasma resistin and CAP-1 mRNA levels were higher in CRC patients (p < 0.001 and p < 0.05, respectively), while resistin mRNA levels were lower (p < 0.001). Negative association existed among plasma resistin and HDL-C concentrations (ρ = − 0.280; p < 0.05). A model including age, body-mass index, HDL-C, low-density lipoprotein cholesterol (LDL-C), and plasma resistin concentrations as independent predictors of CRC showed very good diagnostic accuracy (AUC = 0.898). We found no associations of rs1862513 with the examined markers. Conclusions Our study demonstrated increased plasma resistin and CAP-1 mRNA levels, implying their possible interaction in CRC. The association among plasma resistin and HDL-C might indicate that HDL-C is involved in alterations of resistin's secretion process. As a hallmark of personalized medicine, multi-marker approach in determination of resistin-related parameters might be useful for prediction and prevention of CRC development.

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“…In humans, controversial results on the role of resistin in the development of IR, T2D and metabolic syndrome are described ( 63 , 64 , 69 ). Increased circulating levels are also reported in T1D subjects ( 70 ). A SNP in resistin promoter is, in addition to obesity, also associated with T2D ( 71 ).…”

Section: Resistinmentioning

confidence: 91%

Endocrine and Metabolic Effects of Adipose Tissue in Children and Adolescents / Endokrina in Presnovna Funkcija Maščobnega Tkiva Pri Otrocih in Mladostnikih

Kotnik

Fischer‐Posovszky

Wabitsch

2015

Slovenian Journal of Public Health

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Adipose tissue is implicated in many endocrine and metabolic processes. Leptin was among the first identified adipose-secreted factors, which act in an auto-, para- and endocrine manner. Since leptin, many other adipose tissue factors were determined, some primarily secreted from the adipocytes, some from other cells of the adipose tissue.So-called adipokines are not only involved in obesity and its complications, as are insulin resistance, type 2 diabetes and other components of the metabolic syndrome, but also in growth, reproduction, bone metabolism, immune response, cancer development and many other important biological processes. Research in the field of adipokines has revealed new insights into the physiological and pathophysiologal processes and opened new therapeutic possibilities. In the present article, a special emphasis is devoted to research in children and adolescents.

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Increased Resistin Serum Concentrations in Patients with Type 1 Diabetes Mellitus

Cited by 21 publications

References 37 publications

Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus

Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus

Association among resistin, adenylate cyclase-associated protein 1 and high-density lipoprotein cholesterol in patients with colorectal cancer: a multi-marker approach, as a hallmark of innovative predictive, preventive, and personalized medicine

Endocrine and Metabolic Effects of Adipose Tissue in Children and Adolescents / Endokrina in Presnovna Funkcija Maščobnega Tkiva Pri Otrocih in Mladostnikih

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