Increased Resection Rates and Survival Among Patients Aged 75 Years and Older with Esophageal Cancer: A Dutch Nationwide Population‐Based Study

Abstract

In patients of 75 years or older, surgical treatment and use of definitive CRT have increased between 1989 and 2008. Also, an increase in the use of chemotherapy as a single modality was noted. Overall 5 year survival for all cancer patients was stable but remained poor, while survival of patients who underwent esophagectomy improved significantly in the Netherlands since 1989.

Perioperative survival of elderly head and neck squamous cell carcinoma patients

“…This has been a topic of great debate among the clinical community, but the topic remains relatively unstudied in the head and neck region . As part of the study, a series of literature searches screened over 2,300 articles but found very few that addressed the topic of perioperative outcomes of the elderly versus younger patients . The studies uncovered focused primarily on the cervical esophagus or craniofacial resections.…”

“…The studies uncovered focused primarily on the cervical esophagus or craniofacial resections. For example, Faiz et al and Pultrum et al conducted a review of esophagectomy patients . Each study contained over 200 patients and measured multiple complications including pneumonia, arrhythmia, respiratory distress, and wound infection.…”

“…For example, preservation of speech and swallowing function are just two crucial goals in the ablative and reconstructive process. With regard to perioperative mortality, ablative surgery for HNSCC has a relatively low 30‐day mortality rate compared to other major surgical procedures such as colectomy and aortic valve replacement . As a result, the necessary statistical power to demonstrate trends in mortality, age based or otherwise, requires large sample populations that exceed the number of patients treated at even the largest cancer centers.…”

An Unusual Presentation of Esophageal Cancer: A Case Report and Review of Literature

“…The most common presenting symptoms are dysphagia, odynophagia, and weight loss [2,3]. It is one of the deadliest cancers worldwide with 5-year survival rates of 5.0-26.2% and the eighth most common cancer worldwide [4][5][6][7][8][9]. There are two major types of esophageal cancer: esophageal adenocarcinoma (EAC) and esophageal squamous cell cancer (ESCC) [10].…”

Efficacy of dendritic cell-cytokine-induced killer immunotherapy plus intensity-modulated radiation therapy in treating elderly patients with esophageal carcinoma

“…Unfortunately, one or more chronic diseases such as poor organ tolerance have been reported in these populations (Faiz et al, 2012). At the same time, surgery and chemotherapy are not preferred for these patients because of the complex structure of the esophagus, lymph node metastasis, and other factors.…”