Increased requirement for central venous catheter replacement in paediatric oncology patients with deep venous thrombosis: A multicentre study

Thromboembolism Incidence and Risk Factors in Children with Cancer: A Population-Based Cohort Study

“…6,22,35 TEs can also delay or truncate cancer treatment 18 and lead to CVC replacements. 4 Anti-thrombotic therapy for TE is associated with adverse effects, such as increased risk of major bleeding, reported to occur between 0.3 and 24% of patients. 5 TEs can also lead to chronic morbidities, such as post-thrombotic syndrome 1 or, in the case of CNS thrombosis, neuro-developmental disabilities.…”

“…Thromboembolism (TE) is a well-recognized complication in children and adults with cancer. TEs are associated with chronic morbidity, [1][2][3] delay or modification of treatment, 4 adverse events associated with anticoagulation 5 and rarely mortality. 6 While its epidemiology is well described in adult populations, many areas of uncertainty remain in understanding the incidence and risk factors of TE in children with cancer.…”

Impact of baseline clinical and laboratory features on the risk of thrombosis in children with acute lymphoblastic leukemia: A prospective evaluation

“…Thromboembolism (TE) is a significant complication in children with acute lymphoblastic leukemia (ALL) and is associated with increased risk of morbidity, mortality, and therapy alteration with potential impact on cure rates from ALL . The reported incidence of ALL‐associated symptomatic TE is as high as 16% and that for asymptomatic TE is 37% .…”

Central venous catheter‐related thrombosis and thromboprophylaxis in children: a systematic review and meta‐analysis: discussion

“…There is no convincing evidence that symptomatic DVT is more relevant than asymptomatic DVT, but we do have evidence from the Primary prophylactic Antithrombin Replacement in Kids with Acute lymphoblastic leukemia treated with Asparaginase (PARKAA) study that the degree of venous occlusion was similar in asymptomatic and symptomatic DVT . There are significant acute clinical problems with both asymptomatic DVT and symptomatic DVT, as shown by an increased requirement for multiple replacements of CVCs as compared with non‐DVT controls . It is of note that the risk for an increased requirement for CVC replacement was similar for symptomatic DVT (odds ratio [OR] 5.1, 95% confidence interval [CI] 2.2–11.7) and asymptomatic DVT (OR 5.5, 95% CI 1.05–29).…”