Increased regional cerebral perfusion in contralateral motor and somatosensory areas after median nerve stimulation therapy

Liu, J. T.; Lee, J. K.; Chang, Po-Chun; Sun, Chenming

doi:10.1007/978-3-211-78205-7_11

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…The technique has been widely used due to its inherent advantages, which include the fact that it is non-invasive, safe, and simple to perform. A previous study conducted by Liu et al (2008a) demonstrated that MNS stimulation can improve GCS scores by 2 points and increase regional cerebral perfusion in comatose patients. A randomized, controlled trial by Lei et al (2015) showed that patients 2022) demonstrated a significant increase in CRS-R scores by 3.8 points and an awakening ratio of 53.8% in those treated with MNS, along with an improvement in EEG characteristics.…”

Section: Discussionmentioning

confidence: 95%

“…Our previous animal study found that MNS exerted wake-promoting effects in comatose rats after traumatic brain injury by upregulating orexin-A and BDNF ( Feng and Du, 2016 ). Third, Liu et al (2008a) found that MNS can increase cerebral blood flow in comatose patients. Finally, the ability of MNS to enhance cerebral cortex activity, reduce brain inhibition, and improve EEG activity was supported by the findings of Buitrago et al (2004) .…”

Section: Discussionmentioning

confidence: 98%

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Effect of single and combined median nerve stimulation and repetitive transcranial magnetic stimulation in patients with prolonged disorders of consciousness: a prospective, randomized, single-blinded, controlled trial

Xiong

Tang

et al. 2023

Front. Aging Neurosci.

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ObjectiveTo investigate the efficacy of median nerve stimulation (MNS) combined with repetitive transcranial magnetic stimulation (rTMS), MNS alone, and rTMS alone in elevating the level of consciousness in patients with prolonged disorders of consciousness (pDOC).Participants and methodsWe enrolled 75 eligible inpatients suffering from pDOC as a result of traumatic or non-traumatic brain injury. Participants were randomly assigned to one of the following three treatment groups: (1) rTMS+sham-MNS; (2) MNS + sham-rTMS; or (3) MNS + rTMS. The rTMS protocol involved stimulation above the left dorsolateral prefrontal cortex at a 10 Hz frequency and 90% resting motor threshold. The MNS protocol involved the delivery of a 15–20 mA current at the median nerve point 2 cm from the wrist crease of the right distal forearm. The primary outcome was the change from baseline of the Coma Recovery Scale-Revised (CRS-R) score after treatment. Secondary outcomes included post-treatment changes from baseline of the Glasgow Coma Scale (GCS) score, awaken ratio, electroencephalography (EEG) scores, and the latency and amplitude of N20 on somatosensory evoked potentials.ResultsBefore the intervention, there were no significant differences between groups in the CRS-R, GCS scores, age, duration of pDOC, clinical diagnosis, EEG scores, latency and amplitude of N20, sex, job, marital status, education level, or disease etiology. Within the three groups, the total CRS-R, GCS scores and amplitude of N20 on both side significantly increased and latency of N20 on poor side significantly decreased post-intervention. Significantly greater improvement in CRS-R, GCS total scores, amplitude of N20 on both side and latency of N20 on the poor side were observed in the MNS + TMS group compared to those of the groups receiving rTMS alone or MNS alone. The patients receiving TMS and MNS intervention showed a greater EEG activity improvement, and the EEG activity improved ratio significantly differ between groups, while there were no significant differences in the awakening ratios between the three groups.ConclusionThe combination of MNS + rTMS was more efficacious in improving the level of consciousness than MNS alone or rTMS alone in patients with pDOC.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Effect of single and combined median nerve stimulation and repetitive transcranial magnetic stimulation in patients with prolonged disorders of consciousness: a prospective, randomized, single-blinded, controlled trial

Xiong

Tang

et al. 2023

Front. Aging Neurosci.

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“…Second, boosting cerebral blood ow may be another potential mechanism. Following MNS preformation, regional cerebral perfusion in the contralateral motor and somatosensory areas improved, and enhanced blood ow improved neural survival and promoted cognitive recovery (39). Changes in cortical excitability after stimulation may also be key factors.…”

Section: Discussionmentioning

confidence: 99%

Cognition-Enhancement Effect of Median Nerve Electrical Stimulation in Patients with Cognitive Impairment: A Retrospective Cohort Study

Zhou,

Yang,

You

et al. 2024

World Neurosurgery

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“…Previous studies pointed out that trigeminal nerve stimulation could cause cerebrovasodilation and enhance cerebral perfusion through the trigemino-cerebrovascular system and trigemino-parasympathetic reflex ( 65 ). Median nerve stimulation increased the regional CBF of the contralateral motor and somatosensory cortex ( 68 ). Notably, one study reported that EA to the ophthalmic branch of the trigeminal nerve enhanced CBF in the prefrontal cortex of healthy subjects ( 69 ).…”

Section: Discussionmentioning

confidence: 99%

Potential mechanisms of acupuncture in enhancing cerebral perfusion of ischemic stroke

Wang

Su²,

Cao³

et al. 2022

Front. Neurol.

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Ischemic stroke is the predominant cause of long-term disability and death worldwide. It is attributable to the sudden interruption of regional cerebral blood flow, resulting in brain cell death and neurological impairment. Acupuncture is a widely used adjuvant treatment for ischemic stroke in China and shows promising efficacy in clinical practice. This review mainly focused on the evidence to illustrate several possible mechanisms of acupuncture therapy on cerebral perfusion in ischemic stroke. Studies have shown that acupuncture is probably effective in the enhancement of cerebral perfusion after ischemic stroke. It promotes the improvement of hemodynamics, the release of vasoactive substances, the formation of new blood vessels, as well as the restitution of microcirculation. Multiple factors may contribute to the variability in acupuncture's therapeutic effects, including the acupoint selection, stimulation frequency and intensity, and retaining needle time. Acupuncture has the potential to become a non-pharmacological adjuvant approach to enhance cerebral perfusion in ischemic stroke. Future studies are required to gain our insight into acupuncture as well as accelerate its clinical translation.

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Increased regional cerebral perfusion in contralateral motor and somatosensory areas after median nerve stimulation therapy

Cited by 7 publications

References 25 publications

Effect of single and combined median nerve stimulation and repetitive transcranial magnetic stimulation in patients with prolonged disorders of consciousness: a prospective, randomized, single-blinded, controlled trial

Effect of single and combined median nerve stimulation and repetitive transcranial magnetic stimulation in patients with prolonged disorders of consciousness: a prospective, randomized, single-blinded, controlled trial

Cognition-Enhancement Effect of Median Nerve Electrical Stimulation in Patients with Cognitive Impairment: A Retrospective Cohort Study

Potential mechanisms of acupuncture in enhancing cerebral perfusion of ischemic stroke

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