Increased rate of endometriosis and spontaneous abortion in an<i>in vitro</i>fertilization program: No correlation with epidemiological factors

Matalliotakis, Ioannis; Çakmak, Hakan; Dermitzaki, Despina; Zervoudis, Stefanos; Goumenou, Anastasia G.; Fragouli, Yvoni

doi:10.1080/09513590801948341

Cited by 13 publications

(7 citation statements)

References 22 publications

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“…During pregnancy, an ovarian endometrioma was present in 86% (125) of cases. DIE was present in 12% of patients (18); of these, nine patients had bowel endometriosis, six bladder localization, and three vaginal nodules. Extrapelvic endometriosis was present in 16% of patients (24); of these, five patients had abdominal wall endometriosis, one patient had inguinal localization, and one woman had diaphragmatic endometriosis.…”

Section: Resultsmentioning

confidence: 98%

“…The relationship between endometriosis and pregnancy-induced hypertension/preeclampsia is still being debated [15,16]. Conflicting data on the risk of miscarriage have been reported [17,18]; moreover, some authors found a higher incidence of miscarriage in women with ovarian endometriosis compared to other locations of the disease [19]. An increased caesarean section rate in women affected by endometriosis compared to healthy controls has been reported [20].…”

Section: Introductionmentioning

confidence: 99%

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Endometriosis and Pregnancy: A Single Institution Experience

Porpora

Tomao

Ticino

et al. 2020

IJERPH

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Endometriosis may compromise the physiological course of pregnancy. The aim of this prospective observational study was to evaluate whether endometriosis causes a higher prevalence of obstetric and neonatal complications as well as a higher risk of caesarean section and to detect a possible correlation between the presence, type, and location of endometriosis and obstetric complications, previous surgery, and pregnancy outcome, as well as the influence of pregnancy on the course of the disease. We compared two cohorts of women with spontaneous pregnancy, with and without endometriosis. Obstetric and neonatal outcomes, mode of delivery, presence, type, and location of endometriotic lesions and the effect of pregnancy on the disease were analyzed. A total of 425 pregnancies were evaluated: 145 cases and 280 controls. Patients with endometriosis showed a higher incidence of miscarriage, threatened miscarriage, threatened preterm labor, preterm delivery, placental abruption, and a higher incidence of caesarean section. A significant correlation with pregnancy-induced hypertension and preeclampsia was found in the presence of adenomyosis. No difference in fetal outcome was found. One case of hemoperitoneum during pregnancy was observed. Pregnancy in women with endometriosis carries a higher risk of obstetric complications, such as miscarriage, threatened miscarriage, preterm labor, preterm birth, and a higher caesarean section rate. Endometriosis does not seem to influence fetal well-being.

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Endometriosis and Pregnancy: A Single Institution Experience

Porpora

Tomao

Ticino

et al. 2020

IJERPH

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“…Investigators disagree about the increased risk of spontaneous pregnancy loss after implantation (Al-Azemi et al 2000; Diaz et al 2000; Matalliotakis et al 2008a, 2008b; Metzger et al 1986; Olive et al 1982; Pittaway et al 1988; Wheeler et al 1983; Yanushpolsky et al 1998). Some studies suggest no increased risk of loss (Al-Azemi et al 2000; Diaz et al 2000; Pittaway et al 1988).…”

Section: Impact On the Uterus: Risk Of Miscarriagementioning

confidence: 99%

Cellular and molecular basis for endometriosis-associated infertility

2012

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Endometriosis is a gynecological disease characterized by the presence of endometrial glandular epithelial and stromal cells growing in the extra-uterine environment. The disease afflicts 10%–15% of menstruating women causing debilitating pain and infertility. Endometriosis appears to affect every part of a woman’s reproductive system including ovarian function, oocyte quality, embryo development and implantation, uterine function and the endocrine system choreographing the reproductive process and results in infertility or spontaneous pregnancy loss. Current treatments are laden with menopausal-like side effects and many cause cessation or chemical alteration of the reproductive cycle, neither of which is conducive to achieving a pregnancy. However, despite the prevalence, physical and psychological tolls and health care costs, a cure for endometriosis has not yet been found. We hypothesize that endometriosis causes infertility via multifaceted mechanisms that are intricately interwoven thereby contributing to our lack of understanding of this disease process. Identifying and understanding the cellular and molecular mechanisms responsible for endometriosis-associated infertility might help unravel the confounding multiplicities of infertility and provide insights into novel therapeutic approaches and potentially curative treatments for endometriosis.

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“…Secondly, recent publications indicate that endometriosis increases the risk of late miscarriage and preterm birth [10][11][12]. Placental bed biopsy studies by Kim et al [13,14] have shown that preterm birth with or without rupture of the membranes is associated with incomplete transformation of the uteroplacental arteries.…”

mentioning

confidence: 98%