Increased QT variability in young asymptomatic patients with β‐thalassemia major

Magrì, Damiano; Sciomer, Susanna; Fedele, Francesco; Gualdi, Gianfranco; Casciani, Emanuele; Pugliese, Pellegrina; Anna, Lívia; Ferrazza, Giancarlo; Pasquazzi, Eleonora; Schifano, Erika; Magnanti, Marzia; Matera, Sabrina; Marigliano, Vincenzo; Piccirillo, Gianfranco

doi:10.1111/j.1600-0609.2007.00921.x

Cited by 29 publications

(35 citation statements)

References 36 publications

(48 reference statements)

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“…We found no significant difference in any parameters of QT dynamics in either group of FMF compared with controls. All mean values of QTVI and QTVN, regardless of colchicine response, were also similar to previously published results for healthy persons [22,23]. In addition, the mean QTVI results were much lower than 0.8, the reported QTVI value associated with ventricular arrhythmias in patients with heart failure following myocardial infarction [16].…”

Section: Discussionsupporting

confidence: 90%

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QT interval variability in familial Mediterranean fever: a study in colchicine-responsive and colchicine-resistant patients

et al. 2012

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The association between familial Mediterranean fever (FMF), early atherosclerosis, and electrocardiographic markers for arrhythmias remains controversial. There are conflicting results as to the occurrence of high QT dispersion in FMF. The aim of the present study was to further investigate repolarization dynamics and other repolarization-associated pro-arrhythmogenic markers in FMF patients. To explore repolarization in FMF, patients who responded well to colchicine and patients who had not responded to colchicine, yet were amyloidosis-free, were included. We aimed to evaluate whether increased inflammatory burden, a characteristic of non-responsive patients, was specifically associated with abnormal repolarization. Included in the study were 53 FMF patients (27 colchicine non-responders) and 53 age- and sex-matched control subjects. Electrocardiograms were performed under strict standards. QT variability parameters were computed with custom-made computer software. No significant difference in any of the QT dynamic parameters was found in either FMF group compared with the healthy controls. Mean values of QT variability index, regardless of colchicine response, were similar to previously published results for healthy persons. In conclusion, patients with FMF who are continuously treated with colchicine and have not developed amyloidosis, regardless of their clinical response, have normal QT variability parameters, indicating normal repolarization dynamics and suggesting no increased risk of repolarization-associated cardiac arrhythmias.

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Section: Discussionsupporting

confidence: 90%

“…QT interval was measured according to accepted standards [21]. Mean QT interval (QTm) and QT variance (QTv) and mean RR interval (RRm) and RR variance (RRv) were computed from the respective time series [22]. Mean corrected QT (QTc) was calculated for all patients using Bazett's formula.…”

Section: Methodsmentioning

confidence: 99%

QT interval variability in familial Mediterranean fever: a study in colchicine-responsive and colchicine-resistant patients

et al. 2012

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“…Our main finding in this preliminary and observational study is that QTVI, a known marker of temporal dispersion in cardiac repolarization closely associated with sudden cardiac death risk in various populations [23,25,[33][34][35], is higher in DM1 patients than in healthy controls. Moreover our data seem to suggest a significant relationship between this index and both PR interval length and CTG repeat expansion size, which are well-established predictors of disease severity and arrhythmic risk [1,6,7,10].…”

Section: Discussionmentioning

confidence: 89%

Increased temporal dispersion of myocardial repolarization in myotonic dystrophy Type 1

Magrì

Piccirillo

Bucci

et al. 2012

International Journal of Cardiology

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“…1, left panel). In accordance with previously published works [13,14,15,19,20,21], a single physician (M.C. ), blinded to patient characteristics, measured the QT e from the onset of the QRS complex to the end of the T wave and, when the latter was unclear, the QT interval was defined as the intersection of the isoelectric baseline and the maximum tangent line of the T wave terminal limb.…”

Section: Methodsmentioning

confidence: 99%

Spatial QT Dispersion Predicts Nonsustained Ventricular Tachycardia and Correlates with Confined Systodiastolic Dysfunction in Hypertrophic Cardiomyopathy

Magrì

Piccirillo²,

Ricotta

et al. 2015

Cardiology

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Objectives: An increased dispersion of myocardial repolarization represents one of the mechanisms underlying the arrhythmic risk in hypertrophic cardiomyopathy (HCM). We investigated spatial myocardial repolarization dispersion indices in HCM patients with nonsustained ventricular tachycardia (NSVT) and, contextually, their main clinical determinants. Methods: Fifty-two well-matched HCM outpatients were categorized into two groups according to the presence or the absence of NSVT at 24-hour Holter electrocardiogram (ECG) monitoring. Each patient underwent a clinical examination, including Doppler echocardiogram integrated with tissue Doppler imaging, cardiac magnetic resonance, and 12-lead surface ECG to calculate the dispersion for the following intervals: QRS, Q-T_end (QT_e), Q-T_peak, T_peak-T_end (T_pT_e), J-T_peak, and J-T_end. Results: The NSVT group showed only QT_e dispersion and T_pT_e dispersion values to be significantly higher than their counterparts. NSVT occurrence was independently predicted by late gadolinium enhancement presence (p = 0.021) and QT_e Bazett dispersion (p = 0.030), the latter strongly associated with the myocardial performance index (MPI) obtained at the basal segment of the interventricular septum (p = 0.0004). Conclusion: Our data support QT_e dispersion as an easy and noninvasive tool for identifying HCM patients with NSVT propensity. The strong relationship between QT_e dispersion and MPI allows us to hypothesize an intriguing link between electrical instability and confined myocardial areas of systodiastolic dysfunction.

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Increased QT variability in young asymptomatic patients with β‐thalassemia major

Cited by 29 publications

References 36 publications

QT interval variability in familial Mediterranean fever: a study in colchicine-responsive and colchicine-resistant patients

QT interval variability in familial Mediterranean fever: a study in colchicine-responsive and colchicine-resistant patients

Increased temporal dispersion of myocardial repolarization in myotonic dystrophy Type 1

Spatial QT Dispersion Predicts Nonsustained Ventricular Tachycardia and Correlates with Confined Systodiastolic Dysfunction in Hypertrophic Cardiomyopathy

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