Increased pulse wave velocity in patients with panic disorder: Independent vascular influence of panic disorder on arterial stiffness

Çiçek, Yüksel; Durakoğlugil, Murtaza Emre; Kocaman, Sinan Altan; Güveli, Hülya; Çetın, Mustafa; Erdoğan, Turan; Şahin, İsmail; Doğan, Sıtkı; Çanğa, Aytun

doi:10.1016/j.jpsychores.2012.05.012

Cited by 30 publications

(14 citation statements)

References 33 publications

(32 reference statements)

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“…For example, anxiety, but not depression, has been associated with decreased autonomic nervous system function in patients with hypertension [49], including disrupted sympathetic activity in patients with metabolic syndrome and high blood pressure [50]. In addition, having an anxiety disorder or high anxiety symptoms has been associated with worse arterial stiffness [51, 52] and poorer nighttime dipping [53]. Of interest, one study [50] found that the affective symptom component of depression, not the somatic symptom component nor the total depressive symptom score, was associated with altered sympathetic activity in patients with the metabolic syndrome and high blood pressure [50].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Mood and Anxiety Disorders on Incident Hypertension at One Year

Bacon

Campbell

Arsenault

et al. 2014

International Journal of Hypertension

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Background. Studies assessing the association between psychological factors and hypertension have been equivocal, which may reflect limitations in the assessment of psychological factors. Purpose. To assess the relationship between mood and anxiety disorders, measured using a psychiatric interview, and 1-year incident hypertension. Methods. 197 nonhypertensive individuals undergoing exercise stress testing at baseline provided follow-up data at 1 year. Baseline assessments included a structure psychiatric interview (PRIME-MD), physician diagnosis of hypertension, and measured blood pressure. At follow-up, hypertension status was assessed via self-reported physician diagnosis. Results. Having an anxiety disorder was associated with a 4-fold increase in the risk of developing hypertension (adjusted OR = 4.14, 95% CIs = 1.18–14.56). In contrast, having a mood disorder was not associated with incident hypertension (adjusted OR = 1.21, 95% CIs = 0.24–5.86). Conclusions. There are potential mechanisms which could explain our differential mood and anxiety findings. The impact of screening and treatment of anxiety disorders on hypertension needs to be explored.

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Section: Discussionmentioning

confidence: 99%

The Impact of Mood and Anxiety Disorders on Incident Hypertension at One Year

Bacon

Campbell

Arsenault

et al. 2014

International Journal of Hypertension

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Section: Introductionmentioning

confidence: 99%

“…Previous studies have demonstrated that depression and anxiety may play an important role in vascular aging [ 5 , 11 , 12 ]. Cicek et al [ 11 ] have found that increased pulse wave velocity is related to panic disorder. In addition to the presence of an anxiety disorder, the positive correlation between the severity of anxiety symptoms and vascular stiffness parameters has also been demonstrated in the study, whereas the frequency of panic attacks and its relation to arterial stiffness have not been investigated [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cicek et al [ 11 ] have found that increased pulse wave velocity is related to panic disorder. In addition to the presence of an anxiety disorder, the positive correlation between the severity of anxiety symptoms and vascular stiffness parameters has also been demonstrated in the study, whereas the frequency of panic attacks and its relation to arterial stiffness have not been investigated [ 11 ]. The comorbidity of anxiety and depressive disorders has been shown to be a distinct risk factor for increased arterial stiffness parameters, respectively [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Increased arterial stiffness parameters in panic disorder patients in long term treatment period

et al. 2016

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BackgroundThe relationship between mental stress and cardiovascular disease has been shown in several studies. Panic disorder (PD) is also associated with cardiovascular disease due to increased risk of myocardial infarction. The aim of this study is to evaluate the association between arterial stiffness parameters and depression/anxiety scores in patients with PD.MethodsThe study population consisted of 25 patients with PD and 25 age–sex-matched healthy controls. Depression and anxiety levels were evaluated by Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), respectively. Determination of arterial stiffness parameters was conducted using a Mobil-O-Graph arteriograph system that detected signals from the brachial artery.ResultsWhile baseline characteristics were similar between two groups, BDI and BAI scores were significantly higher in patients with PD (p < 0.005). The pulse wave velocity (PWV) and Augmentation Index (AIx) were also significantly higher in patients with PD (p = 0.001, p = 0.006). There was a moderate correlation between PWV and AIx with BAI scores (r = 0.442, p = 0.001, r = 0.441, p = 0.001). AIx was also positively correlated with BDI scores (r = 0.415, p = 0.03).ConclusionWe demonstrated a significant relationship between arterial stiffness parameters and anxiety/depression scores in patients with PD who receive antidepressant treatment.

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“…Part of the suspicion concerning such etiological links is that persons with panic disorder persist in emergency department recidivism [ 13 , 14 ] and outpatient examinations for chest pain [ 15 , 16 ] despite negative diagnostic results from coronary catheterization, electrocardiogram, or serum markers of myocardial damage [ 17 , 18 ]. These collective findings contrast to more recent evidence revealing plausible mechanisms of cardiopathogenesis attributable to panic disorder and sympathetic discharge of panic attacks, including reversible myocardial ischemia [ 19 , 20 ], diminished heart rate variability (HRV) [ 21 ], change in the QRS complex [ 22 ], especially the QT-interval [ 23 - 25 ], serum low density lipoprotein [ 26 ], microvascular disorders including coronary slow-flow [ 27 ] and microvascular angina [ 15 ], arterial stiffness [ 28 ], and also a preponderance of behavioral factors such as smoking [ 29 ], alcohol use [ 30 ], and overt exercise-avoidance behaviors [ 31 ]. The inconsistency in collective findings to date, coupled with the high coronary healthcare utilization by panic disorder patients [ 32 ], indicates that a meta-analysis is both timely and warranted.…”

Section: Introductionmentioning

confidence: 99%

Panic disorder and incident coronary heart disease: a systematic review and meta-analysis protocol

et al. 2015

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BackgroundThe clinical presentation of panic disorder and panic attack overlaps many symptoms typically experienced in coronary heart disease (CHD). Etiological links between panic disorder and CHD are controversial and remain largely tenuous. This systematic review aims to pool together data regarding panic disorder with respect to incident CHD or myocardial infarction.Methods/DesignElectronic databases (MEDLINE, EMBASE, PsycINFO and SCOPUS) will be searched using a search strategy exploding the topics for CHD and panic disorder. Authors and reference lists of included studies will also be contacted to identify additional published and unpublished studies. Eligibility criteria are as follows: Population: persons without CHD who meet criteria for panic disorder, panic attack, anxiety neurosis or elevated panic disorder symptoms; Comparison: persons without CHD who do not meet criteria for panic disorder, panic attack, anxiety neurosis or elevated panic disorder symptoms; Outcome: verified fatal and non-fatal CHD at follow-up; including coronary revascularization procedure, coronary artery disease, and myocardial infarction. Studies adopting self-report CHD will be ineligible. Screening will be undertaken by two independent reviewers with disagreements resolved through discussion. Data extraction will include original data specified as hazard ratios, risk ratios, and original cell data if available. Risk of bias assessment will be undertaken by two independent reviewers. Meta-analytic methods will be used to synthesize the data collected relating to the CHD outcomes with Cochrane Review Manager 5.3.DiscussionThis systematic review aims to clarify whether panic disorder is associated with elevated risk for subsequent CHD. An evaluation of the etiological links between panic disorder with incident CHD might inform evidence-based clinical practice and policy concerning triaging chest pain patients, diagnostic assessment, and psychiatric intervention with panic disorder patients.Systematic review registrationPROSPERO CRD42014014891.Electronic supplementary materialThe online version of this article (doi:10.1186/s13643-015-0026-2) contains supplementary material, which is available to authorized users.

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Increased pulse wave velocity in patients with panic disorder: Independent vascular influence of panic disorder on arterial stiffness

Cited by 30 publications

References 33 publications

The Impact of Mood and Anxiety Disorders on Incident Hypertension at One Year

The Impact of Mood and Anxiety Disorders on Incident Hypertension at One Year

Increased arterial stiffness parameters in panic disorder patients in long term treatment period

Panic disorder and incident coronary heart disease: a systematic review and meta-analysis protocol

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