Increased Proximal Aortic Diameter is Associated With Risk of Cardiovascular Events and All‐Cause Mortality in Blacks The Jackson Heart Study

Kamimura, Daisuke; Suzuki, Takeki; Musani, Solomon K.; Hall, Michael E.; Samdarshi, Tandaw E.; Correa, Adolfo; Fox, Ervin R.

doi:10.1161/jaha.116.005005

Cited by 24 publications

(24 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, 190 studies were reviewed; of these, 101 did not report data on incident non-fatal or fatal cardiovascular events or all-cause mortality and 41 on AR diameter or ascending aorta data, 33 were review, commentary, editorial articles, and 6 were excluded for miscellaneous reasons. A total of 9 studies, including participants without underlying known aortic pathologies (i.e., aneurysms) or connective diseases and containing sufficient clinical and cardiac imaging data, were included in the final review (17)(18)(19)(20)(21)(22)(23)(24)(25) (Figure 1). The Newcastle-Ottawa Score, used for assessing the quality of the studies, ranged from 7 to 9, and the mean score was 7.8.…”

Section: Resultsmentioning

confidence: 99%

Is Thoracic Aortic Diameter an Independent Predictor of Cardiovascular Disease and Mortality? A Narrative Review

Tadić

Gherbesi

Sala

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Subclinical alterations in cardiac structure and function include a variety of abnormal phenotypes of recognized adverse prognostic values, such as left ventricular hypertrophy (LVH), concentric remodeling, systolic/diastolic dysfunction, left atrial dilatation, and alterations of LV geometry. The excess cardiovascular risk associated with these markers has been documented in multiple clinical settings, such as the general population, hypertensive cohorts, patients with coronary heart disease, diabetes mellitus, chronic heart failure, and chronic kidney disease. On the contrary, the value of aortic root (AR) and ascending aortic diameter in predicting cardiovascular outcomes and all-cause mortality in populations free from overt aortic pathology is still debated. The present review, aimed at pointing out the prognostic implications of thoracic aortic dimensions in populations free from known connective and aortic diseases, suggests that available evidence supporting an association between aortic diameter and cardiovascular events, and all-cause mortality is based on the limited number of studies, conducted with different imaging techniques and definition of the aortic phenotype.

show abstract

Section: Resultsmentioning

confidence: 99%

Is Thoracic Aortic Diameter an Independent Predictor of Cardiovascular Disease and Mortality? A Narrative Review

Tadić

Gherbesi

Sala

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…There is a lack of studies investigating AoD dilation in patients with CAH, which is a measurement associated with aortic wall stiffness, 35 aortic regurgitation, 18 aortic dissection 19 and cardiovascular events such as myocardial infarction, fatal coronary artery disease, stroke, heart failure hospitalisation 20 or aneurysm. 21 of both sexes with CAH.…”

Section: Discussionmentioning

confidence: 99%

“…16,17 Over time, however, chronic stress or disease will result in LV dilation, a decrease in contractile function and eventually progress to heart failure. 17 AoD dilation is a pathology that is strongly associated with the presence and progression of aortic regurgitation, 18 aortic dissection 19 and cardiovascular events such as myocardial infarction, fatal coronary artery disease, stroke, heart failure hospitalisation 20 and aneurysm. 21 Additionally, CAIMT is another important indicator of subclinical vascular disease that is also associated with the risk for myocardial infarction, stroke, death caused by coronary heart disease or a combination of these events.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular dysfunction risk in young adults with congenital adrenal hyperplasia caused by 21‐hydroxylase enzyme deficiency

et al. 2021

View full text Add to dashboard Cite

Background: The association of congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase enzyme (21OHase) deficiency, duration of treatment and dosage with cardiovascular dysfunction in young adults remains unclear. We aimed to evaluate myocardial function, vascular structures and epicardial fat thickness in young adults with CAH as a result of 21OHase deficiency. Correlations between the duration and dose of glucocorticoid therapy and cardiovascular parameters were analysed. Methods: This case-control study of young adults (18-31 years old) included 20 patients (5 men and 15 women) and 16 control subjects (8 men and 8 women).Echocardiographic analysis was performed using high-resolution ultrasound.Results: No ultrasonographic changes in any indices of myocardial function, vascular structures and epicardial fat thickness were found in patients, except for an impaired left ventricular end-diastolic diameter in female patients (28.1 ± 1.6 vs 26.0 ± 2.4 mm/m 2 , P = .021), compared with those in individuals in the control group.Nevertheless, the individual patient values were within the normal range. Multiple

show abstract

“…Furthermore, the proximal aorta undergoes greater longitudinal pulsatile strain during cardiac contraction (O'Rourke, Farnsworth, & O'Rourke, 2008). Consequently, agerelated aortic elongation and dilatation predominantly involve the ascending aorta (Kamimura et al, 2017;Lam et al, 2013;Sugawara et al, 2008). It is therefore not surprising to encounter elongated and dilated ascending aortas in elderly patients undergoing TAVI.…”

Section: Differential Elongation and Dilatation Between The Ascendimentioning

confidence: 99%

Ascending aortic elongation and correlative change in overall configuration of the proximal aorta in elderly patients with severe aortic stenosis

et al. 2020

View full text Add to dashboard Cite

Background: Configurational changes in the proximal aorta are relevant to the procedural difficulty of transcatheter aortic valve implantation (TAVI). Among several morphological changes involving the ascending aorta, elongation is characteristics of elderly patients with aortic stenosis and can compromise the success and safety of TAVI. However, the effect of ascending aortic elongation on the overall morphology of the proximal aorta has not been established. Aims: Our primary purpose was to investigate the effect of ascending aortic elongation on structural changes in the proximal aorta in TAVI candidates. Materials & Methods: In total, 121 consecutive patients with severe aortic stenosis (mean age, 84.5 ± 5.3 years; 69% women) who had undergone preprocedural computed tomography before TAVI were enrolled. We examined the structural anatomy of the proximal aorta in detail, focusing on its elongation, dilatation, tilting, rotation, and wedging. Results: The mean length of the ascending aorta was 68.0 ± 9.2 mm, and the length was significantly correlated with dilatation (R = .278, p = .002), rightward tilting (R = .437, p < .001), clockwise rotation (R = .228, p = .018), and deep wedging (R = −.366, p < .001) of the proximal aorta. Elongation of the ascending aorta was correlated with dilatation, rightward tilting, clockwise rotation, and deep wedging of the proximal aorta in an elderly population with severe aortic stenosis. Discussion: Appreciation of the clinical anatomy around the proximal aorta is required for clinicians involved in TAVI to estimate the procedural difficulty. Conclusion: Elongation of the ascending aorta was associated with dilatation, rightward tilting, clockwise rotation, and deep wedging of the proximal aorta.

show abstract

Increased Proximal Aortic Diameter is Associated With Risk of Cardiovascular Events and All‐Cause Mortality in Blacks The Jackson Heart Study

Cited by 24 publications

References 31 publications

Is Thoracic Aortic Diameter an Independent Predictor of Cardiovascular Disease and Mortality? A Narrative Review

Is Thoracic Aortic Diameter an Independent Predictor of Cardiovascular Disease and Mortality? A Narrative Review

Cardiovascular dysfunction risk in young adults with congenital adrenal hyperplasia caused by 21‐hydroxylase enzyme deficiency

Ascending aortic elongation and correlative change in overall configuration of the proximal aorta in elderly patients with severe aortic stenosis

Contact Info

Product

Resources

About