Increased proteolysis. An effect of increases in plasma cortisol within the physiologic range.

Simmons, Patricia S.; Miles, John M.; Gerich, J. E.; Haymond, Morey W.

doi:10.1172/jci111227

Cited by 274 publications

(136 citation statements)

References 38 publications

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“…The latephase response to an antigenic challenge has been shown to be more pronounced in the evening, when cortisol levels are at a nadir, than early in the morning (33), and changes in cortisol within the physiological range affect both proteolysis and glucose levels (34,35).…”

Section: Discussionmentioning

confidence: 99%

Variations in glucocorticoid levels within the physiological range affect plasma leptin levels

Elimam¹,

Knutsson²,

Brönnegård³

et al. 1998

European Journal of Endocrinology

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Objective: Leptin, the obese gene product, is thought to regulate body fat through its action on hypothalamic receptors that influence satiety. The hormonal regulation of leptin is important, since it might affect adiposity. Leptin regulation in man is poorly understood. We studied the relation between endogenous cortisol and leptin levels as well as the acute and chronic effects of a low dose of dexamethasone (DEX) on plasma leptin levels in healthy male volunteers. Subjects and experimental protocol:The correlation between basal plasma levels of leptin and cortisol and the chronic effect of DEX treatment were studied in 12 subjects. Plasma leptin and cortisol levels were determined every other hour for 24 h, before and after 2 weeks of oral administration of 0.1 mg DEX twice daily. The acute effect was studied in 20 subjects, who received 1 mg DEX at 2300 h. Fasting blood samples were taken at 0800 h on the same day (i.e. before DEX) and on the day after. Results: Under basal conditions, we found a correlation between mean plasma levels of leptin and cortisol (r ¼ 0.7, P < 0.02). Mean plasma leptin levels had increased by 50% after 2 weeks of DEX treatment (P < 0.05). The circadian rhythm of leptin was preserved, but the night peak occurred 2.5 h earlier (P < 0.05). Fasting plasma leptin levels were 20% higher 9 h after 1 mg DEX orally than at the same time on the day before (P < 0.002). Conclusion: Physiological variations in cortisol are involved in the regulation of leptin. European Journal of Endocrinology 139 615-620

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Section: Discussionmentioning

confidence: 99%

Variations in glucocorticoid levels within the physiological range affect plasma leptin levels

Elimam¹,

Knutsson²,

Brönnegård³

et al. 1998

European Journal of Endocrinology

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“…The effect of dexamethasone to decrease the insulin sensitivity of glucose transport, while maintaining a ' normal ' rate of glycolysis, means that the apparent sensitivity of glycolysis to insulin in the muscle was actually increased. Glucocorticoid excess increases the rate of proteolysis [40]. Administration of dexamethasone to rats for 5 days increased muscle concentration of alanine [41] : it is possible that some of these carbons may feed back through pyruvate and contribute to lactate formation.…”

Section: Figure 4 Rates Of Lactate Formation At Various Concentrationmentioning

confidence: 99%

Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle

Dimitriadis

Leighton

Parry-Billings

et al. 1997

Biochemical Journal

239

162

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This study examines the mechanisms of glucocorticoid-induced insulin resistance in rat soleus muscle. Glucocorticoid excess was induced by administration of dexamethasone to rats for 5 days. Dexamethasone decreased the sensitivity of 3-O-methylglucose transport, 2-deoxyglucose phosphorylation, glycogen synthesis and glucose oxidation to insulin. The total content of GLUT4 glucose transporters was not decreased by dexamethasone ; however, the increase in these transporters in the plasma membrane in response to insulin (100 m-units\litre) was lessened. In contrast, the sensitivity of lactate formation to insulin was normal. The content of 2-deoxyglucose in the dexamethasonetreated muscle was decreased at 100 m-units\litre insulin, while the contents of glucose 6-phosphate and fructose 2,6-bisphosphate were normal at all concentrations of insulin studied. The maximal activity of hexokinase in the soleus muscle was not

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“…Glucocorticoids inhibit glucose uptake by peripheral tissues (10,83,86) and cause increased postabsorptive glucose and insulin (100). Whether glucocorticoids exert specific effects directly on the insulin receptor is controversial (78 range increase proteolysis and de novo synthesis of alanine a gluconeogenic substrate (106). Cortisol may augment the effect of other counterregulatory hormones, such as glucagon and epinephrine, raising blood glucose levels (29).…”

Section: Introductionmentioning

confidence: 99%

The Hypothalamic‐Pituitary‐Adrenal Axis in Obesity

1995

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Increased proteolysis. An effect of increases in plasma cortisol within the physiologic range.

Cited by 274 publications

References 38 publications

Variations in glucocorticoid levels within the physiological range affect plasma leptin levels

Variations in glucocorticoid levels within the physiological range affect plasma leptin levels

Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle

The Hypothalamic‐Pituitary‐Adrenal Axis in Obesity

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