Increased proinflammatory markers and lipoperoxidation in obese individuals: Inicial inflammatory events?

Diabetes Care in Venezuela

“…7 This finding suggests that b-cell dysfunction and impaired insulin secretion precede the appearance of T2D. In Venezuelan individuals with obesity, inflammatory events occur without insulin resistance 30 and are an important determinant of multiorgan cardiometabolic dysfunction increasing the risk for obesity-associated T2D. 31 In Latin Americans with obesity, inflammation occurs at lower body fat levels.…”

Inflammation and Oxidative Stress: Critical Role for Metabolic Syndrome

“…Insulin can suppress reactive oxygen species (ROS) generation and p47 phox expression, to increase inhibitor (I)-kB expression in mononuclear cells as well as to suppress plasma concentrations of intracellular adhesion molecule-1 and monocyte chemotactic protein-1, and CRP level [14]. The inflammatory events were mainly observed in obese individuals without IR; the absent of inflammatory events and high levels of insulin in obese subjects with IR, suggest a protector role of insulin for developing inflammatory events [15]. Proteasomal dysfunction and impaired proteostasis in adipocytes, resulting from protein oxidation and/or misfolding, constitute major pathogenic mechanisms in the development of IR at obesity [16].…”

Novel Biomarkers for Cardiovascular Risk in Obese Patients

“…However, there are some controversies between preclinical data and clinical findings. Ryder et al (2015) [45] have shown that similar TNF-alpha tissue expressions were found in obese individuals with and without insulin resistance. Additionally, increased serum TNF-alpha has determined in metabolically healthy obese accompanied to an elevation of both IL-1β level and circulating mononuclear cells bearing on their surface the advanced glycation end product receptor (RAGE), angiotensin II receptor and s100A12 protein (RAGE ligand).…”