Increased production of nitric oxide by neutrophils from patients with chronic granulomatous disease on interferon-gamma treatment

beni, Fariba Naderi; Fattahi, Fatemeh; Mirshafiey, Abbas; Ansari, Mohammad; Mohsenzadegan, Monireh; Movahedi, Masoud; Pourpak, Zahra; Moin, Mostafa

doi:10.1016/j.intimp.2012.01.016

Cited by 20 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IFN‐γ can also increase the production of reactive oxygen species. These activities may explain the therapeutic benefit of IFN‐γ in patients with chronic granulomatous disease due to mutations in NADPH oxidase .…”

Section: Cd4+ T‐cell Effector Cytokines In the Lungmentioning

confidence: 99%

CD4⁺ T‐cell subsets and host defense in the lung

Kolls

2013

Immunological Reviews

View full text Add to dashboard Cite

Summary CD4+ T-helper subsets are lineages of T cells that have effector function in the lung and control critical aspects of lung immunity. Depletion of these cells experimentally or by drugs or human immunodeficiency virus (HIV) infection in humans leads to the development of opportunistic infections as well as increased rates of bacteremia with certain bacterial pneumonias. Recently, it has been proposed that CD4+ T-cell subsets may also be excellent targets for mucosal vaccination to prevent pulmonary infections in susceptible hosts. Here we review recent findings that increase our understanding of T-cell subsets and their effector cytokines in the context of pulmonary infection.

show abstract

Section: Cd4+ T‐cell Effector Cytokines In the Lungmentioning

confidence: 99%

CD4⁺ T‐cell subsets and host defense in the lung

Kolls

2013

Immunological Reviews

View full text Add to dashboard Cite

show abstract

“…In contrast, NO synthase inhibition modified the impact of glutamine by generating levels of IFN-γ similar to those observed in the IO group ( P >0·05). The lower IFN-γ levels were probably responsible for the increased BT observed in the GLN/LN group because the protective effect of IFN-γ on BT may be related to NO production, up-regulated phagocyte levels and, subsequently, increased microbe ingestion ( 39 ) . Furthermore, inducible NO is essential for killing certain bacteria and is potentially important for regulating the proliferation and differentiation of T cells ( 15 ) .…”

Section: Discussionmentioning

confidence: 99%

Effects of nitric oxide synthase inhibition on glutamine action in a bacterial translocation model

et al. 2013

View full text Add to dashboard Cite

Glutamine may be a precursor for NO synthesis, which may play a crucial role in bacterial translocation (BT). The goal of the present study was to investigate the potential effects of glutamine on BT and the immunological response in an experimental model of NO synthase inhibition by NG-nitro-L-arginine methyl ester (l-NAME). Mice were randomly assigned to four groups: sham; intestinal obstruction (IO); IO+500 mg/kg per d glutamine (GLN); IO+GLN plus 10 mg/kg per d l-NAME (GLN/LN). The groups were pretreated for 7 d. BT was induced by ileal ligation and was assessed 18 h later by measuring the radioactivity of 99mTc-Escherichia coli in the blood and organs. Mucosal damage was determined using a histological analysis. Intestinal permeability (IP) was assessed by measuring the levels of 99mTc-diethylenetriaminepentaacetic acid in the blood at 4, 8 and 18 h after surgery. IgA and cytokine concentrations were determined by ELISA in the intestinal fluid and plasma, respectively. BT was increased in the GLN/LN and IO groups than in the GLN and sham groups. IP and intestinal mucosa structure of the sham, GLN and GLN/LN groups were similar. The GLN group had the highest levels of interferon-γ, while IL-10 and secretory IgA levels were higher than those of the IO group but similar to those of the GLN/LN group. The present results suggest that effects of the glutamine pathway on BT were mediated by NO. The latter also interferes with the pro-inflammatory systemic immunological response. On the other hand, IP integrity preserved by the use of glutamine is independent of NO.

show abstract

“…Data from a murine model of CGD, in which IFN-γ was shown to be efficacious in preventing infection, suggest that restoration of the neutrophil oxidative burst is not the mechanism of action [48]. Recent data indicate that IFN-γ therapy strongly increases nitric oxide (NO) production by phagocytes and circulating NO levels [49]. Because NO is a known component of phagocyte-mediated innate immunity against bacterial and fungal pathogens [50], these data might suggest a mechanism for interferon-mediated reduction of infections in patients with CGD.…”

Section: Ifn-γmentioning

confidence: 99%

Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease

Slack

Thomsen

2018

Journal of the Pediatric Infectious Diseases Society

View full text Add to dashboard Cite

Chronic granulomatous disease (CGD) is a primary immunodeficiency that confers a markedly increased risk of bacterial and fungal infections caused by certain opportunistic pathogens. Current evidence supports the use of prophylactic antibacterial, antifungal, and immunomodulatory therapies designed to prevent serious or life-threatening infections in patients with CGD. In this review, we discuss current strategies for the prevention of infections in children and adults with CGD and the evidence that supports those strategies. In addition, we address current challenges and opportunities for future research in this important area.

show abstract

Increased production of nitric oxide by neutrophils from patients with chronic granulomatous disease on interferon-gamma treatment

Cited by 20 publications

References 29 publications

CD4⁺ T‐cell subsets and host defense in the lung

CD4⁺ T‐cell subsets and host defense in the lung

Effects of nitric oxide synthase inhibition on glutamine action in a bacterial translocation model

Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease

Contact Info

Product

Resources

About

Increased production of nitric oxide by neutrophils from patients with chronic granulomatous disease on interferon-gamma treatment

Cited by 20 publications

References 29 publications

CD4+ T‐cell subsets and host defense in the lung

CD4+ T‐cell subsets and host defense in the lung

Effects of nitric oxide synthase inhibition on glutamine action in a bacterial translocation model

Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease

Contact Info

Product

Resources

About

CD4⁺ T‐cell subsets and host defense in the lung

CD4⁺ T‐cell subsets and host defense in the lung