Increased production of inflammatory cytokines in mild cognitive impairment

Magaki, Shino; Mueller, Claudius; Dickson, Cindy; Kirsch, Wolff M.

doi:10.1016/j.exger.2006.09.015

Cited by 128 publications

(85 citation statements)

References 47 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, it was described that IL-6 is overexpressed in Aβ plaques [34] and, in the periphery, plasma IL-6 is significantly higher in AD patients than controls [35]. Moreover, a recent study demonstrated an increased production of IL-6, together with IL-8 and IL-10, in individuals with mild cognitive impairment suggesting that the alteration of immune parameters are early events in AD [36]. Furthermore, an interesting amplification mechanism between ICAM-1 expression and IL-6 production exists.…”

Section: Discussionmentioning

confidence: 97%

Increased Pro-Inflammatory Response by Dendritic Cells from Patients with Alzheimer's Disease

Ciaramella

Bizzoni

Salani

et al. 2010

JAD

View full text Add to dashboard Cite

Abstract. Alzheimer's disease (AD) is characterized by abnormal accumulation of amyloid-β peptide (Aβ) into extracellular fibrillar deposits, paralleled by chronic neuroinflammatory processes. Although Aβ seems to be causative in AD brain damage, the role of the immune system and its mechanisms still remain to be clarified. We have recently shown that normal monocyte-derived dendritic cells (MDDCs), when differentiated in the presence of Aβ1−42, acquire an inflammatory phenotype and a reduced antigen presenting ability. Here we studied MDDCs derived from AD patients in comparison with MDDCs obtained from healthy control subjects (HC). MDDCs from AD patients, at variance with HC-derived cells, were characterized by an augmented cell recovery, a consistent increase in the expression of the pro-inflammatory ICAM-1 molecule, a decrease in the expression of the co-stimulatory CD40 molecule, and an impaired ability to induce T cell proliferation. Furthermore, MDDCs from AD produced higher amounts of IL-6 than HC-derived cells, confirming the more pronounced pro-inflammatory features of these cells in AD patients. Consistent results have been also obtained with monocytes, the MDDC precursors. In fact, while unstimulated monocytes do not appear to be different in AD and HC, after stimulation with lipopolysaccharide, AD monocytes overexpressed ICAM-1 with respect to controls, suggesting that common pathways of monocyte activation and MDDC differentiation are altered in AD. Overall, these findings show that AD-linked dysregulated immune mechanisms exist, which lead to dendritic cell-mediated over-activation of inflammation and impaired antigen presentation, thus supporting the view that immune cell activation could play an important role in AD pathogenesis.

show abstract

Section: Discussionmentioning

confidence: 97%

Increased Pro-Inflammatory Response by Dendritic Cells from Patients with Alzheimer's Disease

Ciaramella

Bizzoni

Salani

et al. 2010

JAD

View full text Add to dashboard Cite

show abstract

“…Lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMC) revealed lower IL-1β levels in AD [116] . In contrast, elevated concentrations or no changes in IL-6 have been reported when PBMCs were stimulated with LPS [117,118] . Several studies reported increased IL-6 levels in the serum and plasma of AD patients, while other studies found no differences [113,114,[119][120][121][122] .…”

Section: Cytokines and Chemokinesmentioning

confidence: 85%

Cerebrospinal fluid and blood biomarkers in Alzheimer’s disease

Humpel

Hochstrasser²

2011

WJP

View full text Add to dashboard Cite

Due to an ever aging society and growing prevalence of Alzheimer's disease (AD), the challenge to meet social and health care system needs will become increasingly difficult. Unfortunately, a definite ante mortem diagnosis is not possible. Thus, an early diagnosis and identification of AD patients is critical for promising, early pharmacological interventions as well as addressing health care needs. The most advanced and most reliable markers are β-amyloid, total tau and phosphorylated tau in cerebrospinal fluid (CSF). In blood, no single biomarker has been identified despite an intense search over the last decade. The most promising approaches consist of a combination of several bloodbased markers increasing the reliability, sensitivity and specificity of the AD diagnosis. However, contradictory data make standardized testing methods in longitudinal and multi-center studies extremely difficult. In this review, we summarize a range of the most promising CSF and blood biomarkers for diagnosing AD.

show abstract

“…Several studies were conducted earlier to conceptualize the possible cause and link between neuroinflammation, oxidative stress, behavior, and cognitive impairments [34,[41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Epalrestat on Memory Impairment in Streptozotocin-Induced Type-2 Diabetic Rats Using Different Behavioral Models.

Jaiswal

Mishra

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The present study was designed to evaluate the protective effects of epalrestat (EPS) on memory and learning in type-2 diabetes.Methods: Sixty percent high-fat diet for 2 weeks and a single dose of streptozotocin (35 mg/kg, ip) was used to induce memory impairment in rats. Once the diabetes is confirmed, test drug (EPS -13.5, 27, and 54 mg/kg, oral) and donepezil (1 mg/kg, oral) were administered to different groups of rats for 4 weeks followed by an assessment of memory and learning deficit using behavioral paradigms: Elevated plus maze (EPM), Morris water maze (MWM), and passive avoidance test.Results: EPS and donepezil showed significant improvement in learning and memory of rats, as indicated by markedly decreased escape latency to reach a hidden platform and increased time spent in target quadrant using MWM task, reduced transfer latency in EPM, and also there is a significant increase in the transfer latencies using passive avoidance test were noted. Memory-enhancing activity of EPS (13.5, 27, and 54 mg/kg) was comparable with the diabetic control group. Conclusion:The study findings suggest that memory-enhancing effect of EPS may be mediated by its antioxidant and anti-inflammatory activities. This recommends the potential effect of EPS therapy as a useful memory restorative agent in the treatment of neurodegenerative disease seen in type-2 diabetes rat.

show abstract

Increased production of inflammatory cytokines in mild cognitive impairment

Cited by 128 publications

References 47 publications

Increased Pro-Inflammatory Response by Dendritic Cells from Patients with Alzheimer's Disease

Increased Pro-Inflammatory Response by Dendritic Cells from Patients with Alzheimer's Disease

Cerebrospinal fluid and blood biomarkers in Alzheimer’s disease

Neuroprotective Effect of Epalrestat on Memory Impairment in Streptozotocin-Induced Type-2 Diabetic Rats Using Different Behavioral Models.

Contact Info

Product

Resources

About