Increased production of antigen-specific B lymphocytes during in vitro immunization using carrier-specific T helper hybridomas

Schilizzi, B. M.; Kroesen, B. J.; The, T. H.; Leij, Lfmh de

doi:10.1016/0022-1759(92)90304-c

Cited by 5 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the serum half-life of TNFα is short and shows large variability, it has been proposed that the assessment of the serum concentrations of soluble TNF receptor may be a more reliable indicator for activation of the TNF system than determination of TNF itself [2]. Two TNF receptors exist: the 55-kD receptor (sTNF-R 55) and the 75-kD receptor (sTNF-R 75) [3].…”

Section: Introductionmentioning

confidence: 99%

Elevated Soluble Tumour Necrosis Factor Receptor Serum Concentrations and Short-Term Mortality in Liver Cirrhosis without Acute Infections

Reichel

Sudhop²,

Braun³

et al. 2000

Digestion

View full text Add to dashboard Cite

Background: Serum concentrations of the soluble 75-kDa tumour necrosis factor receptor (sTNF-R 75) are elevated in patients with severe liver disease and may be linked to mortality as well as to prognostic markers related to clinical outcome and metabolic functions in patients with liver cirrhosis. Patients and Methods: We prospectively studied the relation of sTNF-R 75 to Child-Pugh score points and serum markers of bile acid (total serum bile acids and 7α-hydroxycholesterol), lignocaine (lignocaine metabolite (MEGX) liver function test results) and albumin metabolism (albumin and prealbumin) in 10 healthy individuals and 30 patients with cirrhosis, all free of acute infections. In patients with cirrhosis mortality was recorded for 15 months. Results: Soluble TNF-R 75 concentrations correlated with Child-Pugh score points (r = 0.440, p = 0.015), MEGX test results (r_S = –0.604, p < 0.001) and prealbumin (r_S = –0.527, p < 0.001) in cirrhosis. Nonsurviving patients had almost threefold higher median sTNF-R 75 concentrations (29 ng/ml) than survivors (11 ng/ml) (p = 0.003). Soluble TNF-R 75 serum concentrations with an optimal cut off > 14 ng/ml were significantly more accurate in predicting patient mortality than Child-Pugh score points in a receiver-operator characteristic curve analysis. Conclusion: Soluble TNF-R 75 serum concentrations appear to be a promising new risk factor for mortality in patients with cirrhosis without acute infections.

show abstract

Section: Introductionmentioning

confidence: 99%