Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta‐analysis

Lee, S.; Kim, B.J.; Lee, C.H.; Lee, Woo Seung

doi:10.1111/jdv.14987

Cited by 53 publications

(49 citation statements)

References 32 publications

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“…Published data on AA suggest that vitamin D, due to its immunomodulatory effect, may be involved in AA [ 66 , 67 ]. Lee et al conducted a systematic review and meta-analysis of observational studies on the prevalence of vitamin D deficiency and/or serum vitamin D levels and AA [ 68 ]. These authors analyzed a total of 14 studies that involved 1255 patients with AA and 784 control patients without AA.…”

Section: Vitamin Dmentioning

confidence: 99%

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The Role of Vitamins and Minerals in Hair Loss: A Review

Almohanna

Ahmed

Tsatalis

et al. 2018

Dermatol Ther (Heidelb)

188

156

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People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Micronutrients are major elements in the normal hair follicle cycle, playing a role in cellular turnover, a frequent occurrence in the matrix cells in the follicle bulb that are rapidly dividing. Management of alopecia is an essential aspect of clinical dermatology given the prevalence of hair loss and its significant impact on patients’ quality of life. The role of nutrition and diet in treating hair loss represents a dynamic and growing area of inquiry. In this review we summarize the role of vitamins and minerals, such as vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, iron, selenium, and zinc, in non-scarring alopecia. A broad literature search of PubMed and Google Scholar was performed in July 2018 to compile published articles that study the relationship between vitamins and minerals, and hair loss. Micronutrients such as vitamins and minerals play an important, but not entirely clear role in normal hair follicle development and immune cell function. Deficiency of such micronutrients may represent a modifiable risk factor associated with the development, prevention, and treatment of alopecia. Given the role of vitamins and minerals in the hair cycle and immune defense mechanism, large double-blind placebo-controlled trials are required to determine the effect of specific micronutrient supplementation on hair growth in those with both micronutrient deficiency and non-scarring alopecia to establish any association between hair loss and such micronutrient deficiency. Plain Language Summary: Plain language summary available for this article.

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Section: Vitamin Dmentioning

confidence: 99%

“…These results also suggest that vitamin D supplements or topical vitamin D analogues should be considered for patients with AA and vitamin D deficiency. However, the meta-analysis did not find any clear correlations between extent of hair loss and serum 25-hydroxyvitamin D level [ 68 ].…”

Section: Vitamin Dmentioning

confidence: 99%

The Role of Vitamins and Minerals in Hair Loss: A Review

Almohanna

Ahmed

Tsatalis

et al. 2018

Dermatol Ther (Heidelb)

188

156

View full text Add to dashboard Cite

show abstract

“…What is more, VDR knockout in mice prevents initiation of new hair cycles following morphogenesis . Evidence also suggests vitamin D deficiency is associated with female hair loss disorders and AA . Hair growth was shown to increase with the presence of synthetic vitamin D3 analogues (calcitriol/calcipotriol) in alopecia totalis, AA and in chemotherapy‐induced alopecia mouse models .…”

Section: Associations Between Cholesterol and Hair Pathologiesmentioning

confidence: 99%

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Palmer

Blakeborough

Harries

et al. 2019

Experimental Dermatology

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Lipids and lipid metabolism are critical factors in hair follicle (HF) biology, and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis, and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms by which cholesterol influences pathways involved in proliferation and differentiation within HF cell populations remain largely unknown. As such, expanding our knowledge of the role for cholesterol in regulating these processes is likely to provide new leads in the development of treatments for disorders of hair growth and cycling. This review describes the current state of knowledge with respect to cholesterol homeostasis in the HF along with known and putative links to hair pathologies.

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“…Vitamin D's immunosuppression function in skin helps avoiding auto‐attack and maintaining self‐tolerance by inhibiting the expression of certain inflammatory cytokines in Th1 and Th17 pathways 15 . While the vitamin D deficiency has been found in many other autoimmune diseases including psoriasis, inflammatory bowel disease, systemic and cutaneous lupus erythematosus, several studies were done to find out whether vitamin D deficiency exists in AA 16‐18 . Indian researchers reported AA patients have lower levels of vitamin D than healthy controls 19 and vitamin D deficiency correlates with disease severity 20,21 .…”

Section: Discussionmentioning

confidence: 99%

Serum 25 hydroxyvitamin D levels in alopecia areata, female pattern hair loss, and male androgenetic alopecia in a Chinese population

Zhao

Sheng

Dai

et al. 2020

J of Cosmetic Dermatology

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Background It has been suggested that low vitamin D levels may affect the development of hair loss. Aims Our aim was to evaluate the serum 25‐hydroxy vitamin D [25(OH)D] status in Chinese patients with alopecia areata (AA), female pattern hair loss (FPHL), and male androgenetic alopecia (MAGA) compared with healthy individuals. Methods We performed a case‐control study including 443 AA patients, 657 FPHL patients, 777 MAGA patients, and 2070 normal controls (1064 male and 1006 female healthy individuals) from 2015 to 2017 to analyze the correlation of serum 25(OH)D levels and hair loss in a Chinese population. Results Serum 25(OH)D levels stratified by age, sex, and season were compared between patients and healthy individuals. AA patients' serum 25(OH)D levels were statistically lower than that of controls (P < .0001, α = .05). Serum 25(OH)D levels of FPHL patients (P < .0001, α = .05) and MAGA patients (P = .0005, α = .05) were also significantly lower than counterpart control subjects. Conclusion Our findings suggest an association between serum 25(OH)D levels and alopecia areata, female pattern hair loss, or male androgenetic alopecia in a Chinese population.

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Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta‐analysis

Cited by 53 publications

References 32 publications

The Role of Vitamins and Minerals in Hair Loss: A Review

The Role of Vitamins and Minerals in Hair Loss: A Review

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Serum 25 hydroxyvitamin D levels in alopecia areata, female pattern hair loss, and male androgenetic alopecia in a Chinese population

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