Increased prevalence of tumour infiltrating immune cells in oropharyngeal tumours in comparison to other subsites: relationship to peripheral immunity

Green, Victoria L.; Michno, Anna; Stafford, Nicholas D.; Greenman, John

doi:10.1007/s00262-013-1395-9

Cited by 30 publications

(29 citation statements)

References 41 publications

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“…Lau et al [26] and Green et al [35] have observed a positive correlation between peripheral CD4+ CD25 high Tregs and tumor infiltrating CD4+ CD25 high Tregs in HNSCC patients. In contrast, Wamsom et al [32] who compared CD4+, CD8+, CD4+/CD8+, and FoxP3 T cell subsets have not found any correlation of the levels of these T cells types in the peripheral blood and in the tumor microenvironment between HPV-positive and HPV-negative head and neck tumors.…”

Section: Discussionmentioning

confidence: 99%

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High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV-Positive Oral and Oropharyngeal Squamous Cell Carcinomas

Lukešová

Bouček

Rotnáglová

et al. 2014

BioMed Research International

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Background. Human papillomaviruses (HPVs) have been proved as one of the etiological factors of oropharyngeal squamous cell carcinoma (OPSCC). Patients with tumors of viral etiology have a lower recurrence rate and better prognosis. OPSCC is linked to an alteration in the immune system. Only a limited number of studies have correlated both the immunological parameters and HPV status with patient prognosis. The aim of this study was to determine whether HPV infection and the immunological status influence patient prognosis individually or in concurrence. Material and Methods. Sixty patients with oral and oropharyngeal carcinomas were enrolled. They were divided into HPV-positive and HPV-negative groups based on the expression of HPV 16 E6 mRNA. Basic lymphocyte subpopulations were determined in the peripheral blood by means of flow cytometry. Results. Significantly better disease-specific survival (DSS) was observed in patients with HPV-positive tumors. Nodal status, tumor grade, recurrence, and CD8+/Tregs ratio were identified as factors influencing DSS. A higher level of Tregs and a lower ratio of CD8/Tregs influenced overall survival (OS) independently of HPV status and age. Patients with HPV-positive tumors and high levels of Tregs survived significantly better than patients from the other groups. Conclusion. Better survival is associated with HPV positivity and elevated Tregs levels. Our data suggest that HPV infection and Tregs do not influence patient prognosis in concurrence.

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Section: Discussionmentioning

confidence: 99%

“…A worse prognosis of HNSCC patients with elevated levels of Tregs in the peripheral blood in comparison with normal Tregs levels patients has been documented in a study [34]. In some reports, a positive correlation of the Tregs levels in the peripheral blood and tumor tissue has been reported [20, 26, 32, 35]. …”

Section: Introductionmentioning

confidence: 94%

High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV-Positive Oral and Oropharyngeal Squamous Cell Carcinomas

Lukešová

Bouček

Rotnáglová

et al. 2014

BioMed Research International

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“…In regards to HNSCC, various immune subsets have been correlated with clinical outcome (39,40), but the majority of these reports either focused exclusively on HPV + HNSCC or did not distinguish patient populations based on the HPV status. However, high-throughput analyses revealed that HPV + and HPV -HNSCCs are two distinct clinical entities, which have specific molecular features and an altered immune phenotype characterized by CD8 + T cell infiltration (40).…”

Section: Discussionmentioning

confidence: 99%

Multiparametric immune profiling in HPV– oral squamous cell cancer

et al. 2017

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“…Oropharyngeal squamous cell carcinomas, which arise from the squamous epithelium associated with the lymphoid tissue of the tonsils and base of tongue, have higher numbers of infiltrating iTILs and sTILs compared with other sub-sites [227]. The pre-existing background lymphoid stroma will clearly complicate TIL assessment in these tumors, and an approach similar to that used to assess metastatic deposits in lymph nodes is recommended, that is, to discount any established lymphoid stroma and focus on iTILs in this setting if no desmoplastic stroma is present.…”

Section: Tils In Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

Hendry

Salgado

Gevaert

et al. 2017

Advances in Anatomic Pathology

574

366

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Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as immunotherapies are evaluated and implemented in different tumor types. However, many different approaches can be used to assess and describe the immune response, which limits efforts at implementation as a routine clinical biomarker. In part 1 of this review, we have proposed a standardized methodology to assess tumor infiltrating lymphocytes (TILs) in solid tumors, based on the International Immuno-Oncology Biomarkers Working Group guidelines for invasive breast carcinoma. In part 2 of this review, we discuss the available evidence for the prognostic and predictive value of TILs in common solid tumors, including carcinomas of the lung, gastrointestinal tract, genitourinary system, gynecological system, and head and neck, as well as primary brain tumors, mesothelioma and melanoma. The particularities and different emphases in TIL assessment in different tumor types are discussed. The standardized methodology we propose can be adapted to different tumor types and may be used as a standard against which other approaches can be compared. Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.

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Increased prevalence of tumour infiltrating immune cells in oropharyngeal tumours in comparison to other subsites: relationship to peripheral immunity

Abstract: The level of immune cell infiltration in head and neck squamous cell carcinoma appears to be subsite dependent residing primarily in the stroma and is likely to be dependent on the peripheral immune response.

Cited by 30 publications

References 41 publications

High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV-Positive Oral and Oropharyngeal Squamous Cell Carcinomas

High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV-Positive Oral and Oropharyngeal Squamous Cell Carcinomas

Multiparametric immune profiling in HPV– oral squamous cell cancer

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