Increased prevalence of peripheral blood granulysin-producing cytotoxic T lymphocytes in preeclampsia

Molvarec, Attila; Shiozaki, Arihiro; Ito, Mika; Toldi, Gergely; Stenczer, Balázs; Szarka, András; Nakashima, Akitoshi; Vásárhelyi, Barna; Rigó, János; Saito, Shigeru

doi:10.1016/j.jri.2011.03.012

Cited by 22 publications

(19 citation statements)

References 34 publications

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“…We previously reported that BMI positively correlated with the proportions of granulysin-positive cytotoxic T cells and NK cells in preeclamptic patients. 25) In preeclamptic patients with higher pre-pregnancy BMI, a higher proportion of granulysin-producing cytotoxic T cells in the peripheral blood contributes to stronger proinflammatory Th1-type immune responses.…”

Section: Discussionmentioning

confidence: 99%

Prenatal risk assessment of gestational hypertension and preeclampsia using clinical information

Shiozaki

Tanaka

Ito

et al. 2016

Hypertens Res Pregnancy

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Aim:To assess the risks of developing gestational hypertension (GH) and preeclampsia (PE) during pregnancy based on clinical information. ). The estimated risk ratios predicted subsequent GH and PE with sensitivities of 61.5% and 67.0%, and specificities of 67.0% and 64.4%, respectively. The areas under the receiver operating characteristic curves for GH and PE were 0.70 and 0.68, respectively. Conclusions:The estimated risk ratios determined in this study may identify women at high risk of GH or PE before disease onset.

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Section: Discussionmentioning

confidence: 99%

Prenatal risk assessment of gestational hypertension and preeclampsia using clinical information

Shiozaki

Tanaka

Ito

et al. 2016

Hypertens Res Pregnancy

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“…If the tendency for preeclampsia to skew the cytokine profile of the mother towards an increased Th1/Th2 ratio is reflected in the cytokine pattern of the offspring during pregnancy and early life, it could potentially protect the child from the development of Th2 driven atopic disease [6,22]. However, preeclampsia is a complex inflammatory condition characterised by a variety of pro-inflammatory cytokines beyond the Th1 type of cytokines [10,23]. Pro-inflammatory cytokines, chemokines and adhesion molecules appear to be increased in maternal circulation during preeclampsia [13], and could potentially initiate the development of immunological conditions in the foetus, such as atopic sensitization or diseases [6].…”

Section: Discussionmentioning

confidence: 99%

Birth after preeclamptic pregnancies: association with allergic sensitization and allergic rhinoconjunctivitis in late childhood; a historically matched cohort study

et al. 2014

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BackgroundThe development of allergic sensitization and allergic disease may be related to factors during intrauterine life, but the role of maternal preeclampsia is not known.We studied if maternal preeclampsia is associated with long-term allergic sensitization, allergic rhinoconjunctivitis, atopic dermatitis, asthma and with altered lung function in late childhood.Methods617 children participated in a 1:2 matched and controlled historical cohort study; 230 born after preeclamptic pregnancies and 387 born after normotensive pregnancies. Specific IgE in serum and lung function were measured at the age of 12.8 years and questionnaires on maternal and adolescent data were completed at the ages of 10.8 years (girls) and 11.8 years (boys), and at 12.8 years (both genders). The association between birth after preeclampsia and the main outcome measures allergic sensitization, allergic rhinoconjunctivitis, atopic dermatitis, asthma and lung function in late childhood were analysed with multiple regression analyses, including possible confounders.ResultsSevere maternal preeclampsia was associated with high level allergic sensitization (sum of specific IgE in serum ≥ 3.9 kU/l; the 25 percentile for all children being sensitized); odds ratio (OR): 3.79; 95% confidence interval (CI): (1.54, 9.32); p = 0.015 and with allergic rhinoconjunctivitis in offspring; OR: 2.22, 95% CI: (1.19, 4.14), p = 0.047. Preeclampsia was not associated with atopic dermatitis, asthma or altered lung function in late childhood.ConclusionMaternal preeclampsia was associated with allergic sensitization and allergic rhinoconjunctivitis in offspring in late childhood, but not with other atopic diseases.

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“…Indeed, the proportion of granulysin-producing cytotoxic T-cells notably increases in the peripheral blood of preeclamptic patients in comparison to healthy pregnant women [33]. Preeclamptic women do not show significantly different serum levels of RANTES, a cytokine produced by uNK cells at the human fetal-maternal interface, if compared with healthy pregnant women [34].…”

Section: Maternofetal Immunologymentioning

confidence: 99%

Relationship between Maternal Immunological Response during Pregnancy and Onset of Preeclampsia

Martínez-Varea

Pellicer

Perales‐Marín

et al. 2014

Journal of Immunology Research

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Maternofetal immune tolerance is essential to maintain pregnancy. The maternal immunological tolerance to the semiallogeneic fetus becomes greater in egg donation pregnancies with unrelated donors as the complete fetal genome is allogeneic to the mother. Instead of being rejected, the allogeneic fetus is tolerated by the pregnant woman in egg donation pregnancies. It has been reported that maternal morbidity during egg donation pregnancies is higher as compared with spontaneous or in vitro fertilization pregnancies. Particularly, egg donation pregnancies are associated with a higher incidence of pregnancy-induced hypertension and placental pathology. Preeclampsia, a pregnancy-specific disease characterized by the development of both hypertension and proteinuria, remains the leading cause of maternal and perinatal mortality and morbidity. The aim of this review is to characterize and relate the maternofetal immunological tolerance phenomenon during pregnancies with a semiallogenic fetus, which are the spontaneously conceived pregnancies and in vitro fertilization pregnancies, and those with an allogeneic fetus or egg donation pregnancies. Maternofetal immune tolerance in uncomplicated pregnancies and pathological pregnancies, such as those with preeclampsia, has also been assessed. Moreover, whether an inadequate maternal immunological response to the allogenic fetus could lead to a higher prevalence of preeclampsia in egg donation pregnancies has been addressed.

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Increased prevalence of peripheral blood granulysin-producing cytotoxic T lymphocytes in preeclampsia

Cited by 22 publications

References 34 publications

Prenatal risk assessment of gestational hypertension and preeclampsia using clinical information

Prenatal risk assessment of gestational hypertension and preeclampsia using clinical information

Birth after preeclamptic pregnancies: association with allergic sensitization and allergic rhinoconjunctivitis in late childhood; a historically matched cohort study

Relationship between Maternal Immunological Response during Pregnancy and Onset of Preeclampsia

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