Increased Prevalence of Obstructive Sleep Apnea in Patients With Cleft Palate

Robison, Jacob G.; Otteson, Todd D.

doi:10.1001/archoto.2011.8

Cited by 112 publications

(118 citation statements)

References 31 publications

(45 reference statements)

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“…Some of these patients were likely to have a marginal airway that was unable to tolerate the additional stress of an oral diet. Up until recently, formal polysomnography was not freely available in a timely fashion for our patients at our institution, however, it has been shown that formal polysomnography is much more sensitive at detecting marginal airways in these children [18,19]. We are likely to detect more children in the future with feeding problems that indeed have slight airway compromise just sufficient enough to warrant intervention.…”

Section: Discussionmentioning

confidence: 99%

Pierre Robin sequence: An institutional experience in the multidisciplinary management of airway, feeding and serous otitis media challenges

Glynn¹,

Fitzgerald²,

Earley³

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Pierre Robin sequence: An institutional experience in the multidisciplinary management of airway, feeding and serous otitis media challenges

Glynn¹,

Fitzgerald²,

Earley³

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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“…e) All relevant publications are of class III or IV [30][31][32]. Not all studies concluded that repair of cleft palate increases the risk of OSAS [32][33][34].…”

Section: Literature Reviewmentioning

confidence: 99%

Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management

et al. 2015

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This document summarises the conclusions of a European Respiratory Society Task Force on the diagnosis and management of obstructive sleep disordered breathing (SDB) in childhood and refers to children aged 2-18 years. Prospective cohort studies describing the natural history of SDB or randomised, double-blind, placebo-controlled trials regarding its management are scarce. Selected evidence (362 articles) can be consolidated into seven management steps. SDB is suspected when symptoms or abnormalities related to upper airway obstruction are present (step 1). Central nervous or cardiovascular system morbidity, growth failure or enuresis and predictors of SDB persistence in the long-term are recognised (steps 2 and 3), and SDB severity is determined objectively preferably using polysomnography (step 4). Children with an apnoea-hypopnoea index (AHI) >5 episodes·h, those with an AHI of 1-5 episodes·h −1 and the presence of morbidity or factors predicting SDB persistence, and children with complex conditions (e.g. Down syndrome and Prader-Willi syndrome) all appear to benefit from treatment (step 5). Treatment interventions are usually implemented in a stepwise fashion addressing all abnormalities that predispose to SDB (step 6) with re-evaluation after each intervention to detect residual disease and to determine the need for additional treatment (step 7). @ERSpublications Management of obstructive sleep disordered breathing in childhood should follow a stepwise approach

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“…In comparison to other diseases associated with a high OSA prevalence in children, it is notable that the prevalence of OSA in children and adolescents with EDS was found to be even higher than in children and adolescents with e.g. cleft palate (8.5% with an oAHI ≥1) [22], but lower than in children with Pierre Robin syndrome (85% with a oAHI ≥1) or Down syndrome (73% with an oAHI ≥1) [23, 24]. In contrast to children suffering from these pathologies, in EDS patients craniofacial abnormalities are not risk factors for OSA [4].…”

Section: Discussionmentioning

confidence: 99%

Obstructive Sleep Apnoea in Children and Adolescents with Ehlers-Danlos Syndrome

et al. 2018

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Background: In Ehlers-Danlos syndrome (EDS), a group of monogenic disorders affecting connective tissues, obstructive sleep apnoea (OSA) is highly prevalent in adults. The prevalence of OSA in children with EDS is unknown. Objectives: This prospective cross-sectional study aimed at determining the prevalence of OSA in paediatric EDS patients. Methods: Children with EDS (n = 24) were recruited from the Children’s Hospital Zurich and matched to healthy controls. Participants completed home respiratory polygraphy and questionnaires (Sleep-Related Breathing Disorder Scale [SRBD], Epworth Sleepiness Scale [ESS], and Child Health Questionnaire [CHQ]). The American Academy of Sleep Medicine criteria were applied for OSA diagnosis (obstructive apnoea-hypopnoea index [oAHI] ≥1/h). Conditional logistic regression was used to compare the prevalence of OSA and to adjust for possible confounding. Results: OSA was found in 42% of paediatric EDS patients and in 13% of matched controls (OR = 4.5, 95% CI = 0.97–20.83, p = 0.054). The median oAHI was higher in EDS patients than in controls (0.77/h, IQR = 0.19–1.76, vs. 0.24/h, IQR = 0.0–0.60, p < 0.001 adjusted for age, sex, and BMI z-score). EDS patients had lower scores in most CHQ scales and higher SRBD and ESS scores than controls (0.26, IQR = 0.1–0.35, vs. 0.07, IQR = 0–0.19, p = 0.004); 7 ± 4 vs. 5 ± 4, p = 0.033, respectively). Conclusion: OSA is a previously underestimated EDS-related complication increasing disease burden.

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Increased Prevalence of Obstructive Sleep Apnea in Patients With Cleft Palate

Cited by 112 publications

References 31 publications

Pierre Robin sequence: An institutional experience in the multidisciplinary management of airway, feeding and serous otitis media challenges

Pierre Robin sequence: An institutional experience in the multidisciplinary management of airway, feeding and serous otitis media challenges

Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management

Obstructive Sleep Apnoea in Children and Adolescents with Ehlers-Danlos Syndrome

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