Increased prevalence of Kaposi΄s sarcoma-associated herpesvirus in the Kaposi΄s sarcoma-endemic area of Western Kenya in 1981–2000

Senba, Masachika; Buziba, Nathan; Mori, Nicanor; Morimoto, Kanehito; Nakamura, T.

doi:10.4149/av_2011_02_161

Cited by 18 publications

(4 citation statements)

References 23 publications

(29 reference statements)

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“…However, Georgakopoulos et al , demonstrated that metoprolol, a β-blocker without antioxidative properties, failed to give cardioprotection in lymphoma-treated doxorubicin patients [15]. It was reported that an early start of treatment with angiotensin-converting enzyme inhibitors (ACEIs), in association or not with β-blockers, both improves myocardial contractility [16] and patients’ prognosis [17]. Although the exact mechanism is still poorly understood, the authors highlighted the importance of an early diagnosis, because a delayed treatment (>6 months after the end of chemotherapy) is inefficient [17].…”

Section: Introductionmentioning

confidence: 99%

Increased Beta2-Adrenoceptors in Doxorubicin-Induced Cardiomyopathy in Rat

et al. 2013

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BackgroundThe toxicity of doxorubicin, leading to an irreversible heart failure, limits its use as chemotherapeutic agent. The beneficial effects of early administration of β-blocker were reported in patients with heart failure due to doxorubicin, suggesting an important role of β-adrenoceptors (β-ARs). This study aimed to identify a putative target (β-AR and/or its effectors) at the early phase of a chronic doxorubicin-induced cardiomyopathy (Dox-CM) in a rat model.MethodologyDox-CM was induced by six doxorubicin injections (cumulative dose: 15 mg.kg−1) and validated by echocardiography and left ventricle (LV) catheterization. The β-AR protein expressions in LV were evaluated by western-blot at days 35 (d35) and 70 (d70) after the first doxorubicin injection. Ex vivo cardiac contractility (dP/dtmax, dP/dtmin) was evaluated on isolated heart in response to specific β-AR stimulations at d35.ResultsAt d35, Dox-CM hearts were characterized by mild LV systolic and diastolic dysfunctions, which were exacerbated at d70. In Dox-CM hearts, β3-AR expression was only decreased at d70 (-37±8%). At d35, β1-AR expression was decreased by 68±6%, but ex vivo β1-AR function was preserved due to, at least in part, an increased adenylyl cyclase response assessed by forskolin. β2-AR expression was increased both at d35 (+58±22%) and d70 (+174±35%), with an increase of ex vivo β2-AR response at d35. Inhibition of Gi protein with pertussis toxin did not affect β2-AR response in Dox-CM hearts, suggesting a decoupling of β2-AR to Gi protein.ConclusionThis study highlights the β1/β2-AR imbalance in early Dox-CM and reveals the important role that β2-AR/Gi coupling could play in this pathology. Our results suggest that β2-AR could be an interesting target at early stage of Dox-CM.

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Section: Introductionmentioning

confidence: 99%

Increased Beta2-Adrenoceptors in Doxorubicin-Induced Cardiomyopathy in Rat

et al. 2013

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“…Epidemic KS occurs in patients with AIDS caused by HIV [85]. It is to be noted that before the onset of HIV in 1985 KS had been endemic in Africa [86]. It was reported that KS is caused by Human Herpes Virus 8 (HHV-8, also known as Kaposi sarcoma-associated herpesvirus) in children whose immune system is weakened [87,88].…”

Section: Introductionmentioning

confidence: 99%

Childhood cancers: what is a possible role of infectious agents?

Alibek

Mussabekova

Kakpenova

et al. 2013

Infect Agents Cancer

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The etiology of childhood cancers has been studied for more than 40 years. However, most if not all cancers occurring in children are attributed to unknown causes. This review is focused on the role of infections in cancer development and progression in children. The main infectious agents include human herpesviruses, polyoma viruses, and human papilloma viruses. It is known that infections can lead to carcinogenesis through various mechanisms, and most likely act in addition to genetic and environmental factors. Given the importance of the infectious etiology of childhood cancers, clinical implications and possible prevention strategies are discussed.

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“…In parts of central Africa, KS is the most common tumor seen in hospitals, occurring in both HIV-positive and HIV-negative patients (1)(2)(3)(4). KS tumors are highly vascularized, exhibiting extensive neoangiogenesis, the formation of new blood vessels, which is thought to be critical to the development of the tumor (5).…”

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confidence: 99%