Increased prevalence of JC polyomavirus viruria was associated with arthritis/arthralgia in patients with systemic lupus erythematosus

Mc, Lu; Wy, Yin; Sq, Liu; M, Koo; Ch, Tung; Ky, Huang; Ns, Lai

doi:10.1177/0961203314559629

Cited by 1 publication

(1 citation statement)

References 34 publications

(42 reference statements)

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“…Based on epidemiological and phylogenetic data, it has been hypothesized that HPyV co-evolved with their hosts, leading to high prevalence, low pathogenicity and symptom-less latency in immune competent settings [ 21 ]. HPyV tend to become latent post-primary infection and undergo reactivation among immune-compromised individuals, including HIV positive individuals, organ transplant patients, and individuals affected by autoimmune diseases [ 6 , 22 , 23 , 24 , 25 ]. Immunosuppressant conditions including pregnancy and chronic alcohol abuse are sufficient to lead to PyV reactivation [ 6 ].…”

Section: Polyomavirus Familymentioning

confidence: 99%

Human BK Polyomavirus—The Potential for Head and Neck Malignancy and Disease

Burger-Calderon

Webster‐Cyriaque

2015

Cancers

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Members of the human Polyomaviridae family are ubiquitous and pathogenic among immune-compromised individuals. While only Merkel cell polyomavirus (MCPyV) has conclusively been linked to human cancer, all members of the polyomavirus (PyV) family encode the oncoprotein T antigen and may be potentially carcinogenic. Studies focusing on PyV pathogenesis in humans have become more abundant as the number of PyV family members and the list of associated diseases has expanded. BK polyomavirus (BKPyV) in particular has emerged as a new opportunistic pathogen among HIV positive individuals, carrying harmful implications. Increasing evidence links BKPyV to HIV-associated salivary gland disease (HIVSGD). HIVSGD is associated with elevated risk of lymphoma formation and its prevalence has increased among HIV/AIDS patients. Determining the relationship between BKPyV, disease and tumorigenesis among immunosuppressed individuals is necessary and will allow for expanding effective anti-viral treatment and prevention options in the future.

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