Increased prevalence of Helicobacter pylori in patients with diabetes mellitus

Marrollo, M.; Latella, Giovanni; Melideo, Dina; Storelli, Erica; Iannarelli, R.; Stornelli, P.; Valenti, M; Caprilli, R.

doi:10.1016/s1590-8658(01)80131-6

Cited by 49 publications

(42 citation statements)

References 55 publications

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“…However, the underlying processes responsible an association between infectious agents and atherosclerotic diseases remain unclear. Various potential mechanisms that may act through direct effects, including smooth muscle cell proliferation, lipid accumulation, endothelial dysfunction, and local inflammation, 8 or indirect effects mediated in the circulation through chronic inflammation, 9 cross-reactive antibodies, 10 or alterations of the classic coronary risk factors (ie DM, 11 HT, 12,13 BMI 14 and lipid metabolism [15][16][17] ) have been proposed, so we also examined the association between H. pylori infection and changes in the classic coronary risk factors. We did not find any detrimental effect of H. pylori infection on the classic coronary risk factors in Japanese individuals, which is consistent with a meta-analysis of 18 studies that involved 10,000 people and which also did not find a strong correlation between H. pylori seropositivity and coronary risk factors.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients With Acute Myocardial Infarction

Kinjo

Sato

et al. 2002

Circ J

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Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients With Acute Myocardial Infarction

Kinjo

Sato

et al. 2002

Circ J

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“…Autoimmune gastritis in type 1 diabetes has been associated with iron deficiency (23), although in our survey there was no appreciable difference in Hb between type 1 and type 2 diabetes. Infection with Helicobacter pylori, the major risk factor for atrophic gastritis, may be more common in patients with diabetes and more often associated with the presence of endoscopic lesions and chronic gastritis (24). Nutritional regimens associated with reduced protein and increased fiber and carbohydrate, frequent blood testing, and self-measurement of glucose may contribute to iron depletion.…”

Section: ϫ2mentioning

confidence: 99%

Unrecognized Anemia in Patients With Diabetes

et al. 2003

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OBJECTIVE -Anemia is common in diabetes, potentially contributing to the pathogenesis of diabetes complications. This study aims to establish the prevalence and independent predictors of anemia in a cross-sectional survey of 820 patients with diabetes in long-term follow-up in a single clinic. RESEARCH DESIGN AND METHODS-A full blood count was obtained in addition to routine blood and urine test results for all patients over a 2-year period to encompass all patterns of review. Predictors of the most recent Hb concentration and anemia were identified using multiple and logistic regression analysis.RESULTS -A total of 190 patients (23%) had unrecognized anemia (Hb Ͻ12 g/dl for women and Ͻ13 g/dl for men). This prevalence is two to three times higher than for patients with comparable renal impairment and iron stores in the general population. Independent predictors for Hb were transferrin saturation, glomerular filtration rate (GFR), sex, albumin excretion rate, and HbA 1c level (all P Ͻ 0.0001). Microalbuminuric patients were Ͼ2 times (odds ratio [OR] 2.3) and macroalbuminuric patients Ͼ10 times (OR 10.1) as likely to have anemia than normoalbuminuric patients with preserved renal function (GFR Ͼ80 ml/min).CONCLUSIONS -Anemia is a common accompaniment to diabetes, particularly in those with albuminuria or reduced renal function. Additional factors present in diabetes may contribute to the development of increased risk for anemia in patients with diabetes. Diabetes Care 26:1164 -1169, 2003D iabetes is the single most common cause of end-stage renal disease (1) and therefore the most common cause of renal anemia. In addition, anemia may be more common in diabetes (2) and develop earlier than in patients with renal impairment from other causes (3). The predominance of damage to renal interstitium, systemic inflammation, and autonomic neuropathy have all been suggested as contributors to anemia in diabetic nephropathy (DN) (3). Like many pathophysiological changes of DN, dysfunction may be apparent before demonstrable changes in the glomerular filtration rate (GFR).It is unproven whether anemia directly contributes to the acceleration of complications in DN or to the progression of diabetic renal disease. However, patients with diabetes may be more vulnerable to the effects of anemia because many also have significant cardiovascular disease and hypoxia-induced organ damage. In addition, a number of studies (4 -6) have suggested that Hb levels may be linked to the risk of cardiovascular events, hospitalization, and mortality. Against this, there is no conclusive evidence that correcting anemia significantly improves outcomes in patients with failing renal function, apart from quality of life (7).Because most patients with DN have little overt renal impairment, the majority are supervised by their primary care physician or endocrinologist. However, significant pathology may be present in patients with DN before meeting criteria for referral to a nephrologist (GFR ϳ30 ml/min) (8). In this population, renal anemia may g...

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“…6,7 Long duration of disease, poor hygiene and poor glycaemic control has been associated with diabetes in positive cases. 8,9 There has been association of awareness of disease and the association of H. Pylori positivity in cases of diabetes. 13 when tested in terms of awareness of blood sugars at the diagnosis, knowledge of medicines prescribed, and fundus examination there was no statistical difference noticed in our study.…”

Section: Discussionmentioning

confidence: 99%

“…6 In the last 2 -3 years there are a lot of research publications showing association and non-association of H Pylori infection and diabetes. 7,8,9 Issues of poor socioeconomic status ,poor hygiene and lowering of immunity amongst diabetic patients has been an explanation for the association. 10 There are reports igniting newer point of views i.e.…”

Section: Introductionmentioning

confidence: 99%

A Questionnaire Based Survey on Awareness and Study of Helicobacter Pylori Infection and Ty Pe 2 Diabetes in Central India

Chittawar¹,

Jagat²,

Sharma³

et al. 2015

jemds

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Awareness of Diabetes in India is the need of hour. Questionnaire based survey to assess the awareness was done. Helicobacter Pylori infection is one of the forerunners in the number of people infected and gastrointestinal disorders .Single point cross-sectional observational study was done to evaluate the association of Helicobacter Pylori infection and diabetes. Eighty diabetic patients (49 males, 31 females 55.3±12 years) were enrolled in the study. 25(31%) patients were positive for H pylori and rest 55(69%) patients were negative for the test. There was no gender difference and the awareness of diabetes and its treatment was same in both the groups. Duration of diabetes, glycaemic control and awareness of disease and treatment has got an association of H Pylori infection and type 2 diabetes. Better designed large studies are required to establish the cause and association.

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Increased prevalence of Helicobacter pylori in patients with diabetes mellitus

Cited by 49 publications

References 55 publications

Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients With Acute Myocardial Infarction

Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients With Acute Myocardial Infarction

Unrecognized Anemia in Patients With Diabetes

A Questionnaire Based Survey on Awareness and Study of Helicobacter Pylori Infection and Ty Pe 2 Diabetes in Central India

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