Increased prevalence of essential hypertension in areas previously exposed to fallout due to nuclear weapons testing at the Semipalatinsk Test Site, Kazakhstan

Markabayeva, Akbayan; Bauer, Susanne; Pivina, Lyudmila; Bjørklund, Geir; Chirumbolo, Salvatore; Kerimkulova, Aiman; Semenova, Yuliya; Белихина, Т И

doi:10.1016/j.envres.2018.07.016

Cited by 29 publications

(22 citation statements)

References 39 publications

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“…l Estimate derived by fitting a linear model by (inverse-variance) weighted least squares, applied to the adjusted standardized relative risk provided in Table 2 of Karpov et al (2012), and using the delta method to derive the variance of the ERR: see Appendix A. Average cardiac doses of 0.01, 0.04, 0.1225, and 0.25 Sv were assumed for the respective groups with the following specified ranges of effective doses: 2 of Markabayeva et al (2018). Median cardiac doses of 0.009, 0.041, 0.070, and 0.326 Sv were assumed for the respective groups with the following specified ranges of effective doses: <20, 20-59, 60-185, >185 mSv, as given by Markabayeva et al (2018).…”

Section: Atomic Bomb Survivorsmentioning

confidence: 99%

“…Average cardiac doses of 0.01, 0.04, 0.1225, and 0.25 Sv were assumed for the respective groups with the following specified ranges of effective doses: 2 of Markabayeva et al (2018). Median cardiac doses of 0.009, 0.041, 0.070, and 0.326 Sv were assumed for the respective groups with the following specified ranges of effective doses: <20, 20-59, 60-185, >185 mSv, as given by Markabayeva et al (2018).…”

Section: Atomic Bomb Survivorsmentioning

confidence: 99%

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Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology

Little

Azizova

Hamada

2021

International Journal of Radiation Biology

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Purpose: There are well-known correlations between high and moderate doses (>0.5 Gy) of ionizing radiation exposure and circulatory system damage, also between radiation and posterior subcapsular cataract. At lower dose correlations with circulatory disease are emerging in the Japanese atomic bomb survivors and in some occupationally exposed groups, and are still to some extent controversial. Heterogeneity in excess relative risks per unit dose in epidemiological studies at low (<0.1 Gy) and at low-moderate (>0.1 Gy, <0.5 Gy) doses may result from confounding and other types of bias, and effect modification by established risk factors. There is also accumulating evidence of excess cataract risks at lower dose and low dose rate in various cohorts. Other ocular endpoints, specifically glaucoma and macular degeneration have been little studied. In this paper, we review recent epidemiological findings, and also discuss some of the underlying radiobiology of these conditions. We briefly review some other types of mainly neurological nonmalignant disease in relation to radiation exposure. Conclusions: We document statistically significant excess risk of the major types of circulatory disease, specifically ischemic heart disease and stroke, in moderate-or low-dose exposed groups, with some not altogether consistent evidence suggesting dose-response non-linearity, particularly for stroke. However, the patterns of risk reported are not straightforward. We also document evidence of excess risks at lower doses/dose-rates of posterior subcapsular and cortical cataract in the Chernobyl liquidators, US Radiologic Technologists and Russian Mayak nuclear workers, with fundamentally linear dose-response. Nuclear cataracts are less radiogenic. For other ocular endpoints, specifically glaucoma and macular degeneration there is very little evidence of effects at low doses; radiation-associated glaucoma has been documented only for doses >5 Gy, and so has the characteristics of a tissue reaction. There is some evidence of neurological detriment following low-moderate dose ($0.1-0.2 Gy) radiation exposure in utero or in early childhood.

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Section: Atomic Bomb Survivorsmentioning

confidence: 99%

Section: Atomic Bomb Survivorsmentioning

confidence: 99%

Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology

Little

Azizova

Hamada

2021

International Journal of Radiation Biology

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“…They looked at health outcomes in approximately 1,800 people, including second-and third-generation Polygon survivors. When they focused on individuals whose parents lived in areas that were exposed to radiation from 1949 to 1989, they found that the risks of hypertension went up in correlation with the amount of radiation someone's parents received -a discovery that they found surprising 4 . This multigenerational cardiovascular risk has not been clearly established in populations whose parents and grandparents were affected by the blasts at Hiroshima or Nagasaki, says Jim Smith, a radiation researcher at the University of Portsmouth, UK.…”

Section: Heart Of the Mattermentioning

confidence: 99%

The nuclear sins of the Soviet Union live on in Kazakhstan

Yan¹

2019

Nature

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“…В свою очередь, оценка влияния деятельности полигона требует разработки природоохранных мероприятий по уменьшению техногенного воздействия, ранней диагностики устойчивости генома природных популяций, подвергающихся давлению антропогенного пресса. При этом требуются учет и прогнозирование текущих и отдаленных последствий влияния факторов среды обитания на биоту и здоровье населения, что представляет чрезвычайную актуальность для данного региона и имеет научно-практическую значимость (Bigaliev, 2016;Markabayeva et al, 2018).…”

Section: Introductionunclassified

Ecological and genetic assessment of the consequences of radiation influence on contaminated areas

et al. 2020

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The objects of study are the territory of the districts of the West Kazakhstan region of the Republic of Kazakhstan adjacent to the Kapustin Yar test site: Bokeyordinsky, Zhangalinsky, Zhanibeksky, Kaztalovsky, Akzhayiksky and Syrymsky. The purpose of the work is to conduct a radioecological survey of contaminated areas and to study the content of pollutants in environmental objects, biota (rodents, fish and biosubstrates of domestic animals) by physicochemical methods to assess the risk of the landfill’s impact on biota and humans. This paper presents the results of expeditionary and laboratory research on the pollution of environmental objects in the areas adjacent to the landfill. Indicators of the gamma-survey of the levels of radiation background of the surveyed territories as wellas data on pollution of soil, surface and ground waters, dominant forms of plants, biosubstrates (hair of domestic animals: camel, horse, cow) are given. The generally accepted research methods were used: standard sampling me thods, radiological, atomic adsorption spectrophotometry, cytogenetic (micronucleus) method. A reconnaissance and radioecological examination of environmental objects was carried out using analytical methods, which made it possible to determine the quantitative content of toxic components, the content of priority pollutants and radioactive isotopes. It has been established that the values of the volumetric activity of natural and man-made radionuclides in soil samples, drinking water and biosubstrates (pet hair, human peripheral blood samples) from settlements correspond to the value of the control level for this region. The measurements of radiation activity by gamma radiation showed that along the perimeter of the surveyed territory of the test site and in nearby settlements the radiation level is in the range of 0.06–0.014 μSv/h. A slight excess of the level of radioactivity persists in the area near the fall of missiles in the Bokeyordin region. The investigated regions are characterized by an insignificant level of background radiation, the average DER value for the regions as a whole is 0.14 μSv/h. The absolute maximum, 0.73 μSv/h, was recorded at the points of missile impact in the Kaztal region.

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Increased prevalence of essential hypertension in areas previously exposed to fallout due to nuclear weapons testing at the Semipalatinsk Test Site, Kazakhstan

Cited by 29 publications

References 39 publications

Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology

Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology

The nuclear sins of the Soviet Union live on in Kazakhstan

Ecological and genetic assessment of the consequences of radiation influence on contaminated areas

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