Increased Prevalence of Dysplastic and Malignant Lip Lesions in Renal-Transplant Recipients

King, Gaston N.; Healy, Claire M.; Glover, Mary; Kwan, Jonathan; Williams, David M.; Leigh, Irene M.; Worthington, Helen V; Thornhill, Martin H.

doi:10.1056/nejm199504203321602

Cited by 135 publications

(68 citation statements)

References 17 publications

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“…Further studies are needed to seek the definitive characterisation of the risk factors detected, as well as the identification of other factors that are probably involved. In this sense, the present study suggests a possible hypothesis for future verification: the finding of an association with warts and clinical antecedents in any part of the body suggests the possible implication of variables related to viral components and/or immunosuppression (Dinehart et al, 1990;King et al, 1995). Finally, the risk associated with high alcohol intake may be related, at least in part, to certain nutritional deficits not explored by this study (Franceschi et al, 1991).…”

Section: Discussionmentioning

confidence: 52%

Lifestyles, environmental and phenotypic factors associated with lip cancer: a case–control study in southern Spain

et al. 2003

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The aim of this study was to identify factors related to lip cancer (LC) considering individual characteristics and sociodemographic factors. A case -control study was carried out in the province of Granada (Andalusia, southern Spain). The cases were 105 males with squamous-cell carcinoma of the lip, diagnosed between 1987 and 1989 (aged 20 -70 years) and identified by means of a populationbased Cancer Registry. As controls, a randomised populational sample of 239 males, stratified by age, was used. Multiple logistic regression analysis showed that risk factors are lifetime cumulative tobacco consumption and alcohol consumption. An interaction was found between alcohol consumption and the smoking habit (leaving the cigarette on the lip): OR ¼ 23.6; 95% CI: 3.9 -142.0. Other risk factors identified are clear eyes (OR ¼ 3.5; CI: 95% 1.5 -8.0), sun exposure early in life and cumulative sun exposure during outdoor work (OR ¼ 11.9; 95%: CI: 1.3 -108.9), and skin reaction to sun exposure (Fitzpatrick levels). Another interaction was found between skin reaction and a previous history of common sporadic warts (OR ¼ 4.4; 95% CI: 1.01 -19.1). We conclude that LC is related to phenotype, skin reaction to sun exposure, cumulative and early sunlight exposure, and tobacco and alcohol consumption, as well as a low educational level. Leaving the cigarette on the lip is predictive of LC risk irrespective of cumulative tobacco consumption.

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Section: Discussionmentioning

confidence: 52%

Lifestyles, environmental and phenotypic factors associated with lip cancer: a case–control study in southern Spain

et al. 2003

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“…The occurrence of lip cancer among patients with naturally and medically induced immunosuppression suggests that the high rates among farmers may be due to factors that affect the immune system (47). There may be factors in the agricultural environment that induce immune system deficiencies (40).…”

Section: Discussionmentioning

confidence: 99%

Etiologic clues to lip cancer from epidemiologic studies on farmers

Sa¹

1999

Scand J Work Environ Health

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“…An increased frequency of lesions with epithelial dysplasia of the lips (but not oral mucosa) has been observed in some but not all iatrogenically immunosuppressed patients (King et al, 1995;Seymour et al, 1997).…”

Section: (G) Leukoplakiamentioning

confidence: 99%

“…There is an increased prevalence of dysplastic and malignant lip lesions in immunosuppressed renal-transplant recipients (King et al, 1995) and liver transplant recipients (Haagsma et al, 2001). Oral leukoplakia has progressed rapidly to squamous cell carcinoma in some immunosuppressed patients (Hernandez et al, 2003), and oral squamous cell carcinoma has been reported in immunosuppressed patients without any recorded precursor lesion (Varga and Tyldesley, 1991).…”

Section: (E) Drug-related Neoplasms and Potentially Malignant Lesionsmentioning

confidence: 99%

Adverse Drug Reactions in the Orofacial Region

Scully

Bagán

2004

Critical Reviews in Oral Biology & Medicine

211

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A wide spectrum of drugs can sometimes give rise to numerous adverse orofacial manifestations, particularly dry mouth, taste disturbances, oral mucosal ulceration, and/or gingival swelling. There are few relevant randomized double-blind controlled studies in this field, and therefore this paper reviews the data from case reports, small series, and non-peer-reviewed reports of adverse drug reactions affecting the orofacial region (available from a MEDLINE search to April, 2003). The more common and significant adverse orofacial consequences of drug therapy are discussed.

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Increased Prevalence of Dysplastic and Malignant Lip Lesions in Renal-Transplant Recipients

Abstract: Renal-transplant recipients have an increased prevalence of leukoplakia, dysplasia, and cancer of the lip.

Cited by 135 publications

References 17 publications

Lifestyles, environmental and phenotypic factors associated with lip cancer: a case–control study in southern Spain

Lifestyles, environmental and phenotypic factors associated with lip cancer: a case–control study in southern Spain

Etiologic clues to lip cancer from epidemiologic studies on farmers

Adverse Drug Reactions in the Orofacial Region

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