Increased Prevalence of Coronary Artery Disease in Severe Psoriasis and Severe Atopic Dermatitis

Hjuler, Kasper Fjellhaugen; Böttcher, Morten; Vestergaard, Christian; Deleuran, Mette; Raaby, Line; Bøtker, Hans Erik; Iversen, Lars; Kragballe, Knud

doi:10.1016/j.amjmed.2015.05.041

Cited by 98 publications

(97 citation statements)

References 47 publications

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“…(9) Cardiac computed tomography has been used to compare coronary artery disease in patients with severe AD and psoriasis as well as controls without skin disease. (10) While AD patients did not have as severe coronary artery disease as psoriasis patients, 48% of subjects with AD had coronary artery plaques compared with 21% of controls. Furthermore, AD has been associated with increased platelet activation.…”

Section: Discussionmentioning

confidence: 94%

Atopic dermatitis is not independently associated with nonfatal myocardial infarction or stroke among US women

Drucker

Cho

et al. 2016

Allergy

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We aimed to determine the association between atopic dermatitis (AD) and cardiovascular events in the Nurses' Health Study 2, a cohort of US women. We used logistic regression models to calculate age- and multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) for the associations between history of AD and non-fatal MI and non-fatal stroke. Of the 78,702 participants in our analysis, 7,916 (10%) had a history of AD. There were 392 and 391 cases of non-fatal MI and stroke, respectively. AD was not associated with MI in age- or multivariate-adjusted analyses. AD was significantly associated with stroke in the age-adjusted analysis (OR 1.38, 95% CI 1.03-1.85). This was no longer significant in multivariate models that adjusted for hypertension, hypercholesterolemia and diabetes (OR 1.31, 95% CI 0.98-1.76) and atopic comorbidities (OR 1.17, 95% CI 0.86-1.58). AD was not independently associated with non-fatal MI or stroke in this study.

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Section: Discussionmentioning

confidence: 94%

Atopic dermatitis is not independently associated with nonfatal myocardial infarction or stroke among US women

Drucker

Cho

et al. 2016

Allergy

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“…131–134 Recently, an increased prevalence of coronary artery disease has been reported in severe AD patients without known cardiovascular disease, showing the presence of coronary plaques in 48.1% of AD patients, being significantly increased compared to healthy controls which showed a rate of 21.2%, as assessed by coronary computed tomography angiography. 135 …”

Section: Ad As a Systemic Diseasementioning

confidence: 99%

The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

Brunner

Guttman‐Yassky

Leung

2017

Journal of Allergy and Clinical Immunology

478

461

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Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is driven by both terminal keratinocyte differentiation defects and strong type 2 immune responses. In contrast to chronic plaque-type psoriasis, AD is now understood to be a much more heterogeneous disease, with additional activation of Th22, Th17/IL-23 and Th1 cytokine pathways, depending on the subtype of the disease. In this review, we discuss our current understanding of the AD immune map in both early-onset as well as chronic disease. Clinical studies using broad and targeted therapeutics have helped to elucidate the contribution of various immune axes to the disease phenotype. Importantly, immune activation extends well beyond lesional AD, as non-lesional skin and the blood component harbor AD-specific inflammatory changes. For this reason, future therapeutics will need to focus on a systemic treatment approach, especially in patients suffering from moderate-to-severe disease.

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“…Epidemiological [1,2] and clinical studies [3] have suggested an association between atopic dermatitis (AD) and cardiovascular disease (CVD). Metabolic syndrome is an important risk factor for CVD incidence and mortality, as well as all-cause mortality [4].…”

Section: Introductionmentioning

confidence: 99%

Association between Atopic Dermatitis and the Metabolic Syndrome: A Systematic Review

et al. 2018

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Atopic dermatitis (AD) may be associated with the metabolic syndrome and by that carry an increased risk of cardiovascular disease. Our objective was to provide an update on current knowledge of the association between AD and metabolic syndrome, including each component of the metabolic syndrome. A systematic literature review was performed to identify studies investigating the association between metabolic syndrome and AD from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A total of 14 studies, investigating the association between AD and the metabolic syndrome or AD and components of metabolic syndrome fulfilled the inclusion criteria and were included. It seems unlikely that the association between AD and metabolic syndrome is causal. However, women with AD tended to have components of metabolic syndrome more often than women without AD. There was a positive association between AD and central obesity measured as waist circumference, and this association was stronger for women than men. Despite conflicting results regarding hypertension, the association between hypertension and AD also appeared stronger for women. On the other hand, the association between AD and hyperglycemia appears unlikely, and the association between AD and cholesterol levels was inconsistent. In conclusion, it remains unclear whether AD is a risk factor for metabolic syndrome and its components. However, data indicate that central obesity is associated with AD and that the association is stronger for women than men.

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Increased Prevalence of Coronary Artery Disease in Severe Psoriasis and Severe Atopic Dermatitis

Cited by 98 publications

References 47 publications

Atopic dermatitis is not independently associated with nonfatal myocardial infarction or stroke among US women

Atopic dermatitis is not independently associated with nonfatal myocardial infarction or stroke among US women

The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

Association between Atopic Dermatitis and the Metabolic Syndrome: A Systematic Review

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