Increased prevalence of coeliac disease in diabetes.

Mäki, M; Hällström, O; Huupponen, T; Vesikari, Timo; Visakorpi, J. K.

doi:10.1136/adc.59.8.739

Cited by 109 publications

(43 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All of the children in this study responded to a gluten-free diet, and control of diabetes also improved. In Finland, two studies using antireticulin and antigliadin antibodies showed a prevalance of celiac disease of 2.3 and 3.5%, respectively, among 215 and 201 children with type 1 diabetes (17,18). These children had symptoms that could be attributed to celiac disease but none had diarrhea or symptoms of malabsorbtion.…”

Section: Discussionmentioning

confidence: 95%

Celiac Disease in an Adult Turkish Population with Type 1 Diabetes Mellitus

et al. 2005

View full text Add to dashboard Cite

Celiac disease is a frequent cause of morbidity among patients with type 1 diabetes mellitus. In this study our objective was to determine the prevalance of celiac diasease in a Turkish adult population with type 1 diabetes mellitus. Patients included 122 type 1 diabetes cases from adult diabetes clinic. Total IgA and IgA-antiendomysial antibody (AEA) assays were performed. Patients positive for IgA-AEA were asked to undergo small intestinal biopsy. Of the 122 patients, none was IgA deficient and 3 had positive IgA-AEA results (2.45%). All three of these patients had biopsies diagnostic of celiac disease. The body mass index (BMI) values of patients with positive AEA were significantly lower than normal (P = 0.024). Among the gastrointestinal complaints there was an association between early satiety and AEA positivity (P = 0.02). None of the other gastrointestinal complaints or age, duration of diabetes, glycosylated hemoglobin values, or insulin doses used were found to be related to AEA positivity. Celiac disease has a high prevalence among Turkish paients with type 1 diabetes mellitus. Screening for IgA-AEA during routine investigations of type 1 diabetic patients is important to prevent celiac-associated symptoms.

show abstract

Section: Discussionmentioning

confidence: 95%

Celiac Disease in an Adult Turkish Population with Type 1 Diabetes Mellitus

et al. 2005

View full text Add to dashboard Cite

show abstract

“…It is mandatory for accurate analysis that children with additional pathology are excluded. Both the frequency of coeliac disease [27] as well as of hypothyroidism [31] are increased in type-1 diabetes. As mild forms of both disorders are common, a regular screening of all patients with type-1 diabetes is required.…”

Section: Discussionmentioning

confidence: 99%

“…From these historical reports it remains unclear whether undiagnosed coeliac disease might have been present in some of the patients included, since the association between type-1 diabetes and coeliac disease has only been recognized about 15 years ago [27]. For studies on the growth rate in children with diabetes, a regular screening for anti-gliadin antibodies and exclusion of patients with suspected or proven coeliac disease is therefore mandatory.…”

Section: Introductionmentioning

confidence: 98%

Age at onset and long-term metabolic control affect height in type-1 diabetes mellitus

Holl

Grabert

Heinze

et al. 1998

European Journal of Pediatrics

View full text Add to dashboard Cite

show abstract

“…Children with this disease are at increased risk of celiac disease (2,4), with a prevalence of biopsyconfirmed celiac disease ranging from 1 to 11% (2) (Swedish studies: 3-5% [5,6]). This constitutes a 5-to 10-fold risk increase for celiac disease (7) and may partly be explained by shared HLA in celiac disease and type 1 diabetes (8).…”

mentioning

confidence: 99%

Celiac Disease and Risk of Subsequent Type 1 Diabetes

et al. 2006

View full text Add to dashboard Cite

OBJECTIVE—Earlier studies suggest that children with type 1 diabetes are more likely to have a subsequent diagnosis of celiac disease. However, research is sparse on the risk of subsequent type 1 diabetes in individuals with celiac disease. We sought to determine the risk of subsequent type 1 diabetes diagnosed before the age of 20 years in children and adolescents with celiac disease in a national, general population–based cohort. RESEARCH DESIGN AND METHODS—We identified 9,243 children with a diagnosis of celiac disease in the Swedish national inpatient register between 1964 and 2003. We then identified five reference individuals matched at time of diagnosis for age, calendar year, sex, and county (n = 45,680). Only individuals with >1 year of follow-up after study entry (diagnosis of celiac disease) were included in the analyses. RESULTS—Celiac disease was associated with a statistically significantly increased risk of subsequent type 1 diabetes before age 20 years (hazard ratio 2.4 [95% CI 1.9–3.0], P < 0.001). This risk increase was seen regardless of whether celiac disease was first diagnosed between 0 and 2 (2.2 [1.7–2.9], P < 0.001) or 3 and 20 (3.4 [1.9–6.1], P < 0.001) years of age. Individuals with prior celiac disease were also at increased risk of ketoacidosis or diabetic coma before the age of 20 years (2.3 [1.4–3.9], P = 0.001). CONCLUSIONS—Children with celiac disease are at increased risk of subsequent type 1 diabetes. This risk increase is low considering that 95% of individuals with celiac disease are HLA-DQ2 positive.

show abstract

Increased prevalence of coeliac disease in diabetes.

Cited by 109 publications

References 5 publications

Celiac Disease in an Adult Turkish Population with Type 1 Diabetes Mellitus

Celiac Disease in an Adult Turkish Population with Type 1 Diabetes Mellitus

Age at onset and long-term metabolic control affect height in type-1 diabetes mellitus

Celiac Disease and Risk of Subsequent Type 1 Diabetes

Contact Info

Product

Resources

About