Increased prevalence of celiac disease in patients with oral lichen planus

Cigić, Livia; Gavić, Lidia; Šimunić, Miroslav; Ardalić, Žarko; Biočina‐Lukenda, Dolores

doi:10.1007/s00784-014-1288-0

Cited by 14 publications

(17 citation statements)

References 34 publications

(43 reference statements)

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“…In this study, 25 subjects (39.68%) with OLP reported a history of another autoimmune disease, whereas in the control group, only four (6.35%) reported a history of another autoimmune disease, which is a statistically significant difference (P <0.001). A study by Cigić et al showed a higher incidence of celiac disease in patients with OLP than in people with healthy oral mucosa and among the ordinary population (21). This fact is confirmed by the results of our study because celiac disease was the second most common autoimmune disease in subjects with OLP.…”

Section: Raspravasupporting

confidence: 91%

“…U ovom istraživanju 25 ispitanika s OLP-om (39,68 %) anamnestički navodi i drugu autoimunu bolest, a u kontrolnoj skupini to navodi samo njih četvero (6,35 %), što je statistički značajna razlika (P < 0,001). Istraživanje L. Cigić i njezinih suradnika pokazalo je veću učestalost celijakije kod oboljelih od OLP-a u odnosu prema osobama sa zdravom sluznicom usne šupljine i u usporedbi s općom populacijom (21). To potvrđuju i rezultati našeg istraživanja jer je celijakija bila druga najčešća autoimuna bolest kod ispitanika s OLP-om.…”

Section: Resultsunclassified

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Inflammatory Markers and Incidence of other Autoimmune Diseases in Patients with Oral Lichen Planus

Družijanić

Glavina

Draganja

et al. 2019

Acta Stomatol Croat

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Upalni markeri i učestalost drugih autoimunih bolesti u oboljelih od oralnoga lihena planusa UvodOralni lihen planus (OLP) kronična je imunosna upalna bolest sluznice usne šupljine još nerazjašnjene etiologije. Stanično posredovana imunost potaknuta endogenim i egzogenim utjecajima zauzima posebno mjesto u patogenezi OLP-a i to osobito ako osoba ima genetsku predispoziciju za nastanak bolesti. Bolest se može pojavljivati udruženo s kožnim promjenama te se u tom slučaju govori o kožnom lihenu planusu (LP-u). Oralne promjene mogu se pojavljivati istodobno s kožnim lezijama, ali se u čak 30 do 70 % slučajeva pojavljuju zasebno (1). LP se dovodi u vezu s nizom autoimunih poremećaja, ali ostaje nejasno jesu li bolesnici s LP-om podložniji razvoju drugih autoimunih bolesti ili su one povezane etiološki (2). Kožni LP može se pojaviti i u sklopu nekih autoimunih bolesti kao što su Sjögrenov sindrom (SS), reumatoidni artritis (RA), sarkoidoza, autoimuni hepatitis i vitiligo Abstract Introduction: Oral lichen planus (OLP) is a chronic immune, inflammatory disease of the oral cavity of a still unknown etiology. Materials and methods: The study involved 63 subjects diagnosed with oral lichen planus and 63 subjects without pathologic changes in the oral mucosa who were classified as controls. All subjects were given a detailed medical history at first screening. The medical history of the presence of other autoimmune disease in all subjects was supported by medical records. A sample of venous blood was taken from each subject in order to determine sedimentation rate (SE) and leukocyte count (L) using standard laboratory procedures, and serum C-reactive protein (CRP) concentration values were determined as well. Statistical analysis: The methods of descriptive statistics, χ2-test, the Fisher's exact test, and the Student's t-test were used in the statistical processing of the results. The results were interpreted at a significance level of P <0.05. Results: For all three measured inflammatory markers, there were no statistically significant differences in the number of subjects with elevated values between the test and control groups (P = 0.364 for SE; P = 1.000 for CRP and P = 0.219 for L). The prevalence of other autoimmune disease in the OLP group was higher than in the control group, with statistical significance, and the most common was cutaneous lichen in nine subjects (14.29%) with OLP and celiac disease seven subjects (11.11%). Conclusions: The results showed that there was no significant difference in the average values of the investigated inflammatory markers in blood (SE, CRP and L) between patients with OLP and control subjects, while a significantly higher incidence of other autoimmune diseases in patients with OLP was demonstrated.

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Section: Raspravasupporting

confidence: 91%

Section: Resultsunclassified

Inflammatory Markers and Incidence of other Autoimmune Diseases in Patients with Oral Lichen Planus

Družijanić

Glavina

Draganja

et al. 2019

Acta Stomatol Croat

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“…On the contrary, Pastore et al emphasized conflicting data on the association between CD and RAS. Additional oral signs associated with CD mentioned in the literature include angular cheilitis, glossitis and oral lichen planus (OLP) . As can be seen, among many oral manifestations of CD, evidence between the association of GT and CD is lacking in the literature.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of celiac disease in patients with geographic tongue

Cigić

Galić

Kero

et al. 2016

J Oral Pathology Medicine

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“…Other reported and less frequent associations include lichen planus and lichen sclerosus [ 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 ], linear IgA bullous dermatosis [ 139 , 140 ], prurigo nodularis [ 141 ], pityriasis rubra pilaris and erythroderma [ 142 ], erythema elevatum diutinum [ 143 , 144 , 145 ], necrolytic migratory erythema [ 146 , 147 , 148 ], pityriasis lichenoides [ 140 ], erythema nodosum [ 140 , 149 , 150 , 151 ], porphyria [ 152 , 153 ], cutaneous amyloidosis [ 154 ], generalized acquired cutis laxa [ 155 , 156 ], acquired hypertrichosis lanuginosa [ 157 ], ichthyosis [ 158 ], partial lipodystrophy [ 159 ], transverse leukonychia [ 160 ], atypical mole syndrome, and congenital giant nevus [ 161 ]. Finally, we want to mention that earlier studies reported an increased risk of malignant melanoma in patients with CD, but a recent study refuted this relation [ 162 ].…”

Section: Other Skin Conditions Found In Patients With CDmentioning

confidence: 99%

Cutaneous and Mucosal Manifestations Associated with Celiac Disease

et al. 2018

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Celiac disease (CD) is an immune-mediated, gluten-induced enteropathy that affects predisposed individuals of all ages. Many patients with CD do not report gastrointestinal symptoms making it difficult to reach an early diagnosis. On the other hand, CD is related to a wide spectrum of extra-intestinal manifestations, with dermatitis herpetiformis (DH) being the best characterized. These associated conditions may be the clue to reaching the diagnosis of CD. Over the last few years, there have been multiple reports of the association between CD and several cutaneous manifestations that may improve with a gluten-free diet (GFD). The presence of some of these skin diseases, even in the absence of gastrointestinal symptoms, should give rise to an appropriate screening method for CD. The aim of this paper is to describe the different cutaneous manifestations that have been associated with CD and the possible mechanisms involved.

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Increased prevalence of celiac disease in patients with oral lichen planus

Abstract: Our study confirmed the increased frequency of CD among OLP patients. CD screening should be considered in OLP patients, since untreated CD can present many complications and reduce a patient's quality of life.

Cited by 14 publications

References 34 publications

Inflammatory Markers and Incidence of other Autoimmune Diseases in Patients with Oral Lichen Planus

Inflammatory Markers and Incidence of other Autoimmune Diseases in Patients with Oral Lichen Planus

The prevalence of celiac disease in patients with geographic tongue

Cutaneous and Mucosal Manifestations Associated with Celiac Disease

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