Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis

Dokras, Anuja; Clifton, Shari; Futterweit, Walter; Wild, Robert A.

doi:10.1016/j.fertnstert.2011.10.022

Cited by 158 publications

(129 citation statements)

References 27 publications

(50 reference statements)

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“…Type; GAD most prevalent Anxiety dis. & symp: 25.8% & 39.6% Clarke 2009 – previously described Other chronic physical diseases Dokras 2012 Search: April 2011 # incl. studies 9 Meta‐analysis: yes PCOS subjects and non‐PCOS controls Range: 44–206 Screened clinic populations, 1 study used telephone screening Mostly clinical settings Mostly Western studies Anxiety screening tool Anxiety prev: 1–37.5% in PCOS; 0–13 in controls Prev of generalized anxiety symptoms in PCOS and controls: 20.4% vs 3.9% SAD and OCD more common in PCOS; age effects not rep. Smith 2014 Search: January 2013 # incl.…”

Section: Embasementioning

confidence: 99%

“…studies 18 Meta‐analysis: yes Longitudinal studies to identify behavioral and physiological mechanisms related to anxiety in diabetes More community‐based studies to estimate anxiety prev in diabetes Assess potential moderators Studies on causal mechanisms Original studies Small sample sizes Lacking data on race/ethnicity influence on anxiety prev Differences in scales used to measure anxiety and in aggregation/reporting of results (ex. assessment of 1 anxiety disorder vs. aggregate of several anxiety disorders) Lack of data on prev of anxiety by diabetes type Review Small number of studies Few studies included nondiabetic comparison group 6Clarke 2009 – previously described Other chronic physical diseases Dokras 2012 Search: April 2011 # incl. studies 9 Meta‐analysis: yes Effect of clinical or biochemical factors in relation to hyperandrogenism and anxiety in PCOS Link between PCOS‐specific characteristics and anxiety Larger sample sizes Longitudinal studies for insight into etiology and trajectory of anxiety in PCOS Original studies Few studies on prev on anxiety in PCOS using validated anxiety screening tools Mostly cross‐sectional studies Review Small sample sizes, possible publication bias 5 Smith 2014 Search: January 2013 # incl.…”

Section: Embasementioning

confidence: 99%

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A systematic review of reviews on the prevalence of anxiety disorders in adult populations

et al. 2016

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BackgroundA fragmented research field exists on the prevalence of anxiety disorders. Here, we present the results of a systematic review of reviews on this topic. We included the highest quality studies to inform practice and policy on this issue.MethodUsing PRISMA methodology, extensive electronic and manual citation searches were performed to identify relevant reviews. Screening, data extraction, and quality assessment were undertaken by two reviewers. Inclusion criteria consisted of systematic reviews or meta‐analyses on the prevalence of anxiety disorders that fulfilled at least half of the AMSTAR quality criteria.ResultsWe identified a total of 48 reviews and described the prevalence of anxiety across population subgroups and settings, as reported by these studies. Despite the high heterogeneity of prevalence estimates across primary studies, there was emerging and compelling evidence of substantial prevalence of anxiety disorders generally (3.8–25%), and particularly in women (5.2–8.7%); young adults (2.5–9.1%); people with chronic diseases (1.4–70%); and individuals from Euro/Anglo cultures (3.8–10.4%) versus individuals from Indo/Asian (2.8%), African (4.4%), Central/Eastern European (3.2%), North African/Middle Eastern (4.9%), and Ibero/Latin cultures (6.2%).ConclusionsThe prevalence of anxiety disorders is high in population subgroups across the globe. Recent research has expanded its focus to Asian countries, an increasingly greater number of physical and psychiatric conditions, and traumatic events associated with anxiety. Further research on illness trajectories and anxiety levels pre‐ and post‐treatment is needed. Few studies have been conducted in developing and under‐developed parts of the world and have little representation in the global literature.

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Section: Embasementioning

confidence: 99%

Section: Embasementioning

confidence: 99%

A systematic review of reviews on the prevalence of anxiety disorders in adult populations

et al. 2016

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“…Hence, the conclusion can be drawn that women with PCOS tolerate worse a situation of diagnosis and future uncertainty connected with it than women after mastectomy who have ensured support in various support groups or the support of psycho-oncologists. So, this problem is also worth paying attention to (Dokras, 2012;Niemi, 2013;Stefanaki et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Loss of attributes of femininity, anxiety and value crisis. Women with polycystic ovary syndrome compared to women after mastectomy and in menopause

Mącik

2016

Health Psychology Report

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Background Polycystic ovary syndrome (PCOS) is a relatively widespread disease and a main cause of fertility problems. The disease diagnosis is frequently related to changes in the value hierarchy. However, it can be treated as a “loss of/threat to” femininity. Similar aspects of the loss of part of femininity are connected with menopause and mastectomy. Participants and procedure One hundred and forty-five women were examined in total: 42 with the PCOS diagnosis, 20 after mastectomy, 42 in menopause and 41 healthy women (reference group). Standard measurement methods were used: the Value Crisis Questionnaire by P. Oleś and the IPAT Anxiety Scale – Self Analysis Form by R. B. Cattell. Results Women suffering from PCOS obtained significantly higher indexes of both crisis and anxiety compared to other groups, whereas women after mastectomy and in menopause did not differ between one another in tested variables, and they did not differ from healthy women either. It was noted that the most relationships between variables were observed in the group of women in menopause (significant correlations between almost all dimensions), while there are few relationships in women after mastectomy. In women with PCOS (a relatively small number of correlations) relationships of the greatest strength relate to the relationships of negative self-esteem and guilt proneness with all dimensions of the value crisis. Conclusions Polycystic ovary syndrome, despite having a relatively non-threatening course, is experienced much more strongly by women compared to mastectomy and menopause. It is associated with strong internal anxiety and degradation of the value hierarchy.

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“…A lelki zavarok összefügghetnek a hirsutismussal, az elhízással és/vagy a meddőséggel, de az okok tisztázása további vizsgálatokat igényel [70]. Az okoktól függetlenül a lelki problémák pszichológiai gondozása javasolt, ami jelentősen javítja a PCOS-betegek életminőségét [71].…”

Section: A Pszichés Problémák Kezeléseunclassified

A polycystás ovarium szindróma tüneteinek bizonyítékokon alapuló terápiája

Gődény

Csenteri

2015

Orvosi Hetilap

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A polycystás ovarium szindróma a nők leggyakoribb endokrin és anyagcsere-betegsége. A különböző klinikai formá-ban jelentkező betegség kardinális tünetei közé tartoznak a hiperandrogén bőrtünetek és/vagy emelkedett szérum-androgénszintek, oligo-vagy amenorrhoea, anovuláció miatt kialakuló meddőség és esetenként a petefészek polycystás szerkezete. A szindróma kezelése függ a klinikai megjelenéstől, az életkortól, az alkalmazott diagnosztikus technológiák pontosságától, valamint attól, hogy mely kritériumrendszer alkalmazásával történt a diagnózis felállítá-sa. A bizonyítékon alapuló, megfelelően kiválasztott terápiás technológiával javul a kórkép kezelésének eredményes-sége, hatékonysága, a betegek biztonsága, életminősége és várható élettartama. A közlemény a rendelkezésre álló irodalmi adatok, elsősorban a legmagasabb szintű bizonyítékoknak tekinthető szisztematikus irodalmi áttekintések és metaanalízisek felhasználásával ismerteti a szindrómához társuló tünetek, az elhízás, a hyperandrogenismus, a vér-zészavarok, a meddőség és a lelki problémák kezelésének lehetőségeit. Orv. Hetil., 2015, 156(45), 1803-1815. Kulcsszavak: PCOS, klinikai tünetek, EBM, terápia Evidence-based therapy of polycystic ovarian syndromePolycystic ovary syndrome is recognized as the most common hormonal and metabolic disorder likely to affect women. The heterogeneous endocrinopathy is characterized by clinical and/or biochemical hyperandrogenism, oligo-or amenorrhoea, anovulatory infertility, and polycystic ovarian morphology. The syndrome is often associated with obesity, hyperinsulinemia and adversely affects endocrine, metabolic, and cardiovascular health. The symptoms and complaint of the patients vary with age. To maximise health gain of the syndrome, adequate, evidence based effective, effi cient and safe treatment is necessary. This article summarises the highest available evidence provided by studies, meta-analysis and systematic reviews about the therapeutical possibilities for treating obesity, hyperandrogenism, menstrual abnormalities, infertility and psychological problems related to polycystic ovary syndrome ÖSSZEFOGLALÓ KÖZLEMÉNYRövidítések 2TDM = 2-es típusú diabetes mellitus; A = androsztendion; BMI = (body mass index) testtömegindex; CC = clomifen-citrát; CPA = ciproteron-acetát; CI = (confi dence interval) megbízhatósági tartomány, konfi denciaintervallum; DHEAS = dehidroepiandroszteron-szulfát; DHT = dihidro-tesztoszteron; DRSP = drospirenon; EBM = (evidence-based medicine) bizonyítékokon alapuló orvoslás; EE = etinil-ösztradiol; EE+CPA = etinil-ösztradiolt és ciproteron-acetátot tartalmazó kombinált készítmény; EE+DRSP = etinil-ösztradiolt és drospirenont tartalmazó kombinált készítmény; EMA = (European Medicines Agency) Európai Gyógyszerügynökség; FAI = (free androgen *A Debreceni Egyetem, Klinikai Központ, Szülészeti és Nőgyógyászati Klinika endokrin munkacsoportjának tagja.

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Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis

Cited by 158 publications

References 27 publications

A systematic review of reviews on the prevalence of anxiety disorders in adult populations

A systematic review of reviews on the prevalence of anxiety disorders in adult populations

Loss of attributes of femininity, anxiety and value crisis. Women with polycystic ovary syndrome compared to women after mastectomy and in menopause

A polycystás ovarium szindróma tüneteinek bizonyítékokon alapuló terápiája

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