Increased prevalence and risk of non‐alcoholic fatty liver disease in overweight and obese patients with Type 2 diabetes in South China

Yi, Min; Chen, R.‐P.; Chen, H.

doi:10.1111/dme.13174

Cited by 28 publications

(21 citation statements)

References 34 publications

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“…Increased BMI is an established risk factor of NAFLD/NASH . Similarly, even in this population that could be considered lean relative to Western population, we also observed a higher risk of cirrhosis mortality in those with higher BMI.…”

Section: Discussionsupporting

confidence: 58%

“…36 Increased BMI is an established risk factor of NAFLD/NASH. 37,38 Similarly, even in this population that could be considered lean relative to Western population, we also observed a higher risk of cirrhosis mortality in those with higher BMI. However, interestingly, this increased risk with higher BMI was only observed in those without diabetes at baseline.…”

Section: Discussionsupporting

confidence: 47%

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Association between diabetes mellitus and cirrhosis mortality: the Singapore Chinese Health Study

Goh

Pan

Chow

et al. 2016

Liver International

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Background and Aim Diabetes mellitus has been linked to liver cirrhosis-related mortality in Western populations, but less is known about this relationship in Asian populations. We studied the impact of diabetes on the risk of cirrhosis mortality in a population-based cohort among Chinese in Singapore. Methods We used data collected and analysed from the Singapore Chinese Health Study, a prospective community based cohort of 63,275 subjects aged 45 to 74 years during enrolment between 1993 and 1998. Information on diet, lifestyle and medical history was collected via structured questionnaire. Mortality cases from cirrhosis in the cohort were identified via linkage with nationwide death registry up to 31 December 2014. Cox proportional regression models were used to estimate the associations with adjustment for risk factors of cirrhosis. Results After a mean follow-up of 16.9 years, there were 133 deaths from cirrhosis. Diabetes was associated with an increased risk of cirrhosis mortality [hazard ratio (HR): 2.80; 95% confidence interval (CI): 2.04-3.83], and for both viral (HR: 2.20; 95% CI: 1.18-4.11) and non-viral hepatitis related cirrhosis mortality (HR: 3.06; 95% CI: 2.13-4.41). The association between diabetes and non-viral hepatitis-related cirrhosis mortality was stronger among participants of body mass index less than 23 kg/m2 (HR: 7.11; 95% CI: 3.42-14.79) compared to heavier individuals (HR: 2.28; 95% CI: 1.20-4.35) (Pinteraction=0.02). Conclusion Diabetes is a risk factor for cirrhosis mortality, especially for non- viral hepatitis related cirrhosis in population with body mass index considered low or normal in Asia.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionsupporting

confidence: 47%

Association between diabetes mellitus and cirrhosis mortality: the Singapore Chinese Health Study

Goh

Pan

Chow

et al. 2016

Liver International

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“…In a study conducted by Yi et al the prevalence of NAFLD higher in males when compared to female. 8 In our study the prevalence of NAFLD in type 2 diabetes mellitus is higher in female patients. A similar trend was observed by S. Kalra et al in which the prevalence of NAFLD is higher in females.…”

Section: Discussionsupporting

confidence: 48%

A Study of Prevalence of Non Alcoholic Fatty Liver in Type 2 Diabetes Mellitus Patients

Rohini¹,

Aarthi²

2019

IJCMR

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Background: NAFLD is commonly associated with Type 2 diabetes mellitus in clinical practice it is overlooked despite the significant clinical implications of NAFLD in Type 2 diabetes mellitus. This study was done to estimate the prevalence of NAFLD in diabetes mellitus. Material and methods: This study was conducted in 150 patients with Type 2 diabetes mellitus in Chengalpattu medical college over a period of 1 year. This study was a cross sectional non interventional study. Results: The prevalence of NAFLD was 51. 3% and the prevalence was higher among females (42.6%) and higher in patients with central obesity and dyslipidemia. Conclusion: Since NAFLD is a common association with diabetes mellitus and the risk of complications is higher in patients with NAFLD, early detection is needed to adopt preventive strategies.

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“…However, there was a great disparity across studies in the estimated prevalence of NAFLD in T2DM patients, ranging from 45% to 80%. [ 14 , 15 ] This variation may be associated with the sample characteristics and the techniques used to make the diagnosis of NAFLD. [ 16 ] Therefore, this meta-analysis aimed to explore the pooled prevalence of NAFLD in T2DM patients by synthesizing the reported data.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

et al. 2017

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Background:Nonalcoholic fatty liver disease (NAFLD) is emerging as a public health issue worldwide and is highly prevalent in patients with type 2 diabetes mellitus (T2DM). However, there was a great disparity across studies in the estimated prevalence of NAFLD in T2DM patients. This meta-analysis, therefore, aimed to estimate the pooled prevalence of NAFLD in T2DM patients.Methods:Electronic databases of PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure, and Wanfang were searched using MeSH terms to identify relevant studies. Eligibility assessment and data extraction were conducted independently by 2 investigators and a meta-analysis was performed to synthesize the data. Heterogeneity was evaluated using the Cochran Q test and quantified using the I2 statistic. Publication bias was assessed using both the Begg and Egger tests. Subgroup analyses were performed to identify the possible sources of heterogeneity.Results:Twenty-four studies involving 35,599 T2DM patients were included in this meta-analysis, of which 20,264 were identified with NAFLD. A high degree of heterogeneity (I2 = 99.0%, P < .001) was observed among the eligible studies, with the reported prevalence ranging from 29.6% to 87.1%. The pooled prevalence of NAFLD in T2DM patients, by a random-effects model, was 59.67% (95% confidence interval: 54.31–64.92%). Sensitivity was low and both the Begg test and Egger test showed low possibility of publication bias. Subgroup analyses indicated that the prevalence of NAFLD in T2DM patients differed by gender, obesity, hypertension, dyslipidemia, coronary heart disease, and chronic kidney disease.Conclusions:The high pooled prevalence of NAFLD in T2DM patients found in this study significantly underscores the need for early assessment of NAFLD and the importance of strengthening the management of NAFLD in T2DM patients.

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Increased prevalence and risk of non‐alcoholic fatty liver disease in overweight and obese patients with Type 2 diabetes in South China

Abstract: The prevalence of non-alcoholic fatty liver disease in overweight and obese patients with Type 2 diabetes in South China is high. Multiple metabolic disorders were significantly associated with non-alcoholic fatty liver disease in overweight and obese patients with Type 2 diabetes.

Cited by 28 publications

References 34 publications

Association between diabetes mellitus and cirrhosis mortality: the Singapore Chinese Health Study

Association between diabetes mellitus and cirrhosis mortality: the Singapore Chinese Health Study

A Study of Prevalence of Non Alcoholic Fatty Liver in Type 2 Diabetes Mellitus Patients

Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

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