Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis

Ayers, Chris M.; Schlosser, Rodney J.; O’Connell, Brendan P.; Atkinson, Carl; Mulligan, R. M.; Casey, Sarah; Bleier, Benjamin S.; Wang, Eric; Sansoni, E. Ritter; Kuhlen, James L.; Mulligan, Jennifer K.

doi:10.1002/alr.20046

Cited by 41 publications

(40 citation statements)

References 38 publications

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“…In contrast, the numbers of IL-13, but not IL-4, mRNA-positive cells were increased in the CRS subjects without atopic symptoms compared with the normal controls. Results of these investigations suggest that the relationship between the two cytokines IL-4/IL-13 and the polyp formation is not necessarily associated with the induction of eosinophilic inflammation (al Ghamdi et al, 1997;Ayers et al, 2011;Bhakta and Woodruff, 2011). In our study, similarly to POSTN, we found that the IL-13 expression level was markedly higher in the NP tissues compared with the adjacent mucosa.…”

Section: Discussionsupporting

confidence: 54%

Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps

Miłoński

Zielińska‐Bliźniewska

Majsterek

et al. 2015

DNA and Cell Biology

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most frequently encountered chronic nasal diseases with a significant impact on patient quality of life. The aim of our study was therefore to investigate the association between the POSTN, IL-4, and IL-13 gene expression and the nasal polyp development. The objective of this study was to determine differential expression of POSTN, IL-4, and IL-13 genes in the mucosa and polyps of 63 patients with CRSwNP and 23 chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) when compared with patients with nasal septum deviation (n=18) who were used as controls. The expression level was investigated using reverse transcription-polymerase chain reaction assays in the polyp tissue and the mucosa of paranasal sinus collected while undergoing functional endoscopic sinus surgery. Expression of the mRNAs of all three genes, IL-4, IL-13, and POSTN, was significantly greater in the paired tissues of CRS patients with NPs or without NPs than in control subjects, with highest levels of POSTN and IL-13 seen in CRSwNP. An increased level of POSTN, IL-4, and IL-13 gene expression may be related to the development of chronic rhinosinusitis with nasal polyps, but polyp formation seemed to be associated especially with POSTN and IL-13 expression.

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Section: Discussionsupporting

confidence: 54%

Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps

Miłoński

Zielińska‐Bliźniewska

Majsterek

et al. 2015

DNA and Cell Biology

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“…Moreover, the proportion of CD4 ' CCR8' T-cells reflecting Th2 cells is higher in rhinitis when compared to controls (42). Moreover, this observation could be confirmed in the nasal mucosa tissue of allergic fungal rhinosinusitis patients (39).…”

Section: Nasal Mucosa Dendritic Cell Type and Quantificationsupporting

confidence: 52%

“…Moreover, an active role for pDCs in allergic inflammation was also confirmed in allergen challenge studies with an important role for the DC stimulation of TNFa (38). Elevated numbers of DCs (CD209 DC-Sign) were observed in allergic fungal rhinosinusitis (39). Models of AR showed an elevated number of DCs (CD11c-positive cells with a dendritic morphology) (4,40,41).…”

Section: Nasal Mucosa Dendritic Cell Type and Quantificationmentioning

confidence: 82%

Dendritic cells as critical players in allergic rhinitis

KleinJan

2014

Advances in Cellular and Molecular Otolaryngology

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“…[533][534][535] In support of this hypothesis in CRSwNP, polyps exhibit large numbers of type 2 ILCs 536, 537 and dendritic cells. 538,539 The critical upstream epithelial cytokine is not completely clear, but high levels of TSLP activity have been identified in polyp homogenates. 540,541 Some evidence suggests that IL-33 may play a role as well, but these studies have yet to demonstrate increased expression of this cytokine at the protein level in NP tissue.…”

Section: Discussionmentioning

confidence: 99%

“…1094 NPs contain elevated levels of dendritic cells, mast cells, eosinophils, and Th2 cytokines. 538,1079,1080,1094,1097,1098 AFRS mucosa has a predominance of CD8+ T cells vs CRSwNP mucosa, which has elevated CD20+ B-cells. 1086 Various studies demonstrate elevation of fungal and nonfungal IgE within AFRS mucosa, and local IgE correlates with sinonasal eosinophilia.…”

Section: Viiig Crswnp and Afrs: Differences In Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

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554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis

Cited by 41 publications

References 38 publications

Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps

Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps

Dendritic cells as critical players in allergic rhinitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

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