Increased Prefrontal Activation During Pain Perception in Major Depression

Bär, Karl‐Jürgen; Wagner, Gerd; Koschke, Mandy; Boettger, Silke; Boettger, Michael Karl; Schlößer, R.; Sauer, Heinrich

doi:10.1016/j.biopsych.2007.02.011

Cited by 118 publications

(63 citation statements)

References 47 publications

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“…The procedure for data preprocessing was comparable to that used in our previous studies 17,31 and is described in detail in the Appendix. We focused our statistical analysis on the comparison contrasting the painful thermal stimulation at 45°C with the nonpainful 37°C condition.…”

Section: Functional Data Analysismentioning

confidence: 99%

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa

Bär

Cruz

Berger

et al. 2015

jpn

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Section: Functional Data Analysismentioning

confidence: 99%

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa

Bär

Cruz

Berger

et al. 2015

jpn

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“…Previous research examined somatosensory perception of pain in the DLPFC area [25,28,29] and its role in emotional control [30]. In the present study, tDCS resulted in …”

Section: Discussionmentioning

confidence: 72%

Changes in the Sensory Function after Transcranial Direct Stimulation on Dorsolateral Prefrontal Cortex Area

Min¹

2015

Journal of the Korea Academia-Industrial cooperation Society

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Transcranial direct current stimulation (tDCS) is a neuromodulatory technique that delivers a low-intensity direct current to the cortical areas, thereby facilitating or inhibiting spontaneous neuronal activity. This study was designed to examine the changes in various sensory functions after tDCS. A single-center, single-blinded, randomized trial was conducted to determine the effect of a single session (August 4 to August 29) of tDCS with the current perception threshold (CPT) in 50 healthy volunteers. Nerve conduction studies (NCS) were performed in relation to the median sensory and motor nerves on the dominant hand to discriminate peripheral nerve lesions. The subjects received anodal tDCS with 1mA for 15 minutes under two different conditions, with 25 subjects in each group. The conditions were as follows: tDCS on the dorsolateral prefrontal cortex (DLPFC) and sham tDCS on DLPFC. The parameters of the CPT was recorded with a Neurometer ® at frequencies of 2000, 250 and 5 Hz in the dominant index finger to assess the tactile sense, fast pain and slow pain, respectively. In the test to measure the CPT values of the DLPFC in the anodal tDCS group, the values increased significantly in all of 250 and 5 Hz. All CPT values decreased for the sham tDCS. These results showed that DLPFC anodal tDCS can modulate the sensory perception and pain thresholds in healthy adult volunteers. This study suggests that tDCS may be a useful strategy for treating central neurogenic pain in rehabilitation medicine.

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“…Indépendamment de la modalité de stimulation, neuf études ont trouvé que les seuils de douleur étaient élevés dans la DM, relativement aux sujets sains [1,[3][4][5]26,27,32,42,43]. Ces seuils étaient diminués dans trois études [4,36,45] et quatre études ont échoué à trouver des différences entre les groupes [19,26,43,47].…”

Section: Seuils De Douleurunclassified

“…Indépendamment de la mesure de la douleur (seuil de douleur, tolérance à la douleur, douleur subjective, mais pas les seuils de sensation), des signes d'hypoalgésie dans la DM, par rapport aux sujets sains, ont été décrits dans sept études utilisant des stimuli thermiques [3][4][5]13,27,31,42], trois études ont rapporté des signes d'hyperalgésie [19,36,45], alors que cinq études ont échoué à démontrer des différences intergroupes sur certaines réponses [17,26,36,43,47].…”

Section: Stimulation Thermiqueunclassified

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L’évaluation expérimentale de la douleur dans la dépression majeure

Potvin

2011

Douleur analg

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Les relations entre la dépression majeure (DM) et la douleur sont plus complexes qu'on ne le croyait originalement. La DM s'accompagne fréquemment de symptômes somatiques douloureux, et elle constitue un facteur de risque dans le développement de la douleur chronique. Paradoxalement, la plupart des études ayant évalué expérimentalement la perception de la douleur dans la DM ont décrit des répon-ses hypoalgésiques chez les patients. La présente revue de littérature a pour objectif de pondérer les évidences empiriques et d'identifier les facteurs contribuant à l'hétéro-généité des résultats. Pour citer cette revue : Douleur analg. 24 (2011). Mots clés Dépression majeure · Hypo-/hyperalgésie · Antidépresseurs · Mécanismes endogènes d'inhibition de la douleurAbstract The relationship between major depressive disorder (MDD) and pain is more complex than originally thought. MDD is frequently accompanied by somatic pain symptoms and is a risk factor for chronic pain. Paradoxically, most experimental studies on pain perception in MDD have described hypoalgesic responses in patients. This literature review aims to evaluate the empirical findings and identify the factors contributing to heterogeneity of results. To cite this journal: Douleur analg. 24 (2011).

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Increased Prefrontal Activation During Pain Perception in Major Depression

Cited by 118 publications

References 47 publications

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa

Changes in the Sensory Function after Transcranial Direct Stimulation on Dorsolateral Prefrontal Cortex Area

L’évaluation expérimentale de la douleur dans la dépression majeure

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