Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology

Hammiche, Fatima; Vujkovic, Marijana; Wijburg, Willeke; Vries, J.H.M. de; Macklon, Nick S.; Laven, Joop; Steegers‐Theunissen, Régine P.M.

doi:10.1016/j.fertnstert.2010.11.021

Cited by 105 publications

(100 citation statements)

References 29 publications

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“…A suplementação com ácido fólico, recomendação da American Society for Reproductive Medicine (ASRM) para todas as mulheres em idade fértil foi complementada com a adoção de maior ingestão de frutas e verduras verde-escuras, fontes de vários nutrientes essenciais para o processo de nutrição que envolve todas as etapas da vida e em especial, na fecundação e gestação, uma vez que está relacionado à programação metabólica que interfere não apenas no sucesso da RA, mas também no desenvolvimento da criança e na sua saúde na vida adulta (citar estudos de programação metabólica). Hammiche et al (2011) relatam que consumir peixe pelo menos 2 vezes na semana durante o tratamento de FIV/ICSI é uma forma de aumentar o índice de ômega 3 ingerido. Os autores identificaram que os ácidos graxos de cadeia longa contribuem com os níveis basais de estrogênio, número de folículos e morfologia embrioná-ria após a estimulação ovariana.…”

Section: Resultsunclassified

Nutritional counseling impact on assisted reproduction treatment outcomes

Halpern¹,

Sardinha²,

Setti³

et al. 2013

JBRA Assisted Reproduction

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Section: Resultsunclassified

Nutritional counseling impact on assisted reproduction treatment outcomes

Halpern¹,

Sardinha²,

Setti³

et al. 2013

JBRA Assisted Reproduction

View full text Add to dashboard Cite

“…Notably, omega-3 fatty acids have already been reported to positively influence embryo morphology which is a surrogate parameter in IVF. In a study on humans, the increased intake of omega-3 was associated with higher estradiol levels, as well as with increased embryo quality [23] . The 3 other ingredients used in our preparation have also been reported to exert reproductive effects.…”

Section: Discussionmentioning

confidence: 98%

The Impact of a Standardized Oral Multinutrient Supplementation on Embryo Quality in in vitro Fertilization/Intracytoplasmic Sperm Injection: A Prospective Randomized Trial

Nouri

Walch²,

Weghofer³

et al. 2016

Gynecol Obstet Invest

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The role of micronutrients in fertility has recently gained increased attention. We aimed to test the impact of a standardized, multinutrient supplementation on outcomes after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a pilot study. One hundred women undergoing IVF/ICSI were prospectively included and randomized to receive either a multinutrient supplementation named PROfertil® female that included folic acid, selenium, vitamin E, catechins, glycyrrhizin, diosgenin, damiana and omega-3-fatty acids (study group; n = 50), or 400 µg folic acid (control group; n = 50). Outcome parameters were embryo quality on day 3 after oocyte retrieval (good quality vs. poor quality) and the clinical pregnancy rate. In an intention-to-treat analyses, a higher rate of women with at least one good quality embryo (with at least 6 cells and a fragmentation rate <20%) were found for the study (29/50, 58.0%) compared to the control group (18/50, 36.0%; p = 0.045 in chi-square test; relative risk 1.611, 95% CI 1.009-2.597). In conclusion, a multinutrient supplementation that includes folic acid, selenium, vitamin E, catechins, glycyrrhizin, diosgenin, damiana and omega-3-fatty acids seems beneficial in terms of embryo quality.

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“…Yet, high-dose n-3 PUFA supplementation reduced oocyte fertilization in mice [38]. Whereas higher precycle n-3 PUFA compromised folliculogenesis, improved embryo morphology was reported for women undergoing IVF with ICSI [39]. Still, no difference was reported in fertilization rate between IVF women following high and low n-3 PUFA diets in one study despite a higher pregnancy rate [40], and a larger ratio of n-3 relative to n-6 PUFAs was associated with lower implantation and pregnancy rates in another study of IVF women [41].…”

Section: Discussionmentioning

confidence: 98%

Urine cortisol concentration as a biomarker of stress is unrelated to IVF outcomes in women and men

Butts

Bloom

Frye

et al. 2014

J Assist Reprod Genet

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Purpose Our primary objective was to assess associations between urine cortisol as a biomarker of psychological stress and in vitro fertilization (IVF) outcomes. A secondary objective was to assess associations between toxic metals and cortisol. Methods Urine and blood specimens were collected from 52 women and 28 male partners completing a first IVF procedure, on the day of oocyte retrieval. Urine cortisol was measured with an enzyme-linked immunosorbent assay. Mercury (Hg), cadmium (Cd), and lead (Pb) were determined in blood and Cd in urine by inductively coupled plasma-mass spectrometry.Results No associations were indicated for cortisol with IVF outcomes in multivariable regression models adjusted for covariates. However, we detected positive linear associations for cortisol and urine Cd (β=9.96, 95%CI 1.52, 21.44) and blood Hg (β=1.44, 95%CI 0.31, 3.18). An exploratory stratified analysis suggested a potential inverse association between urine cortisol and oocyte fertilization among women with low, but not high blood Hg. Conclusion While limited, these preliminary data suggest that psychological stress may not play a major role in IVF outcomes, which therefore could be one less concern for couples and their clinicians. Our data also raise the possibility for toxic metals to modify associations between cortisol and IVF outcomes among women. However, these preliminary results require corroboration in an experimental animal model and confirmation in a larger, more definitive observational study.

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Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology

Cited by 105 publications

References 29 publications

Nutritional counseling impact on assisted reproduction treatment outcomes

Nutritional counseling impact on assisted reproduction treatment outcomes

The Impact of a Standardized Oral Multinutrient Supplementation on Embryo Quality in in vitro Fertilization/Intracytoplasmic Sperm Injection: A Prospective Randomized Trial

Urine cortisol concentration as a biomarker of stress is unrelated to IVF outcomes in women and men

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