“…Human RuvBL1 and RuvBL2 are overexpressed in a variety of cancers inculding colorectal (Carlson et al, 2003). Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a, (Lauscher et al;2007;Ki et al, 2007), gastric (Li et al, 2010), bladder (Sanchez-Carbayo et al, 2006), mesothelioma (Zhan et al, 2007), non-small cell lung cancer (Dehan et al, 2007), as well as in several types of acute (Andersson et al, 2007) or chronic leukemias (Haslinger et al, 2004), in multiple myeloma (Zhan et al, 2007) and high-grade lymphoma (Nishiu et al, 2002). In ovarian cancer cell lines, microcell-mediated chromosome transfer and expression microarray analysis identified nine genes associated with functional suppression of tumorogenicity; AIFM2, AKTIP, AXIN2, CASP5, FILIP1L, RBBP8, RGC32, RUVBL1 and STAG3.…”