Increased pontin expression in human colorectal cancer tissue

Pontin and Reptin, Two Related ATPases with Multiple Roles in Cancer

“…Unexpectedly, we detected strongly enhanced cytoplasmic expression of Reptin (4) and Pontin 4 in liver cancer and of Pontin in colon cancer (5). All known functions of Pontin and Reptin are consistent with a nuclear localization, and both proteins indeed have been localized in the nucleus in many cell types from various organisms.…”

“…The regulation of Reptin or Pontin expression has not been reported as such in other large series of tumors. However, reanalysis of microarray data available in the Oncomine database 5 shows a deregulated expression of these proteins in several cancers such as bladder cancer and melanoma.…”

The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis

“…For example, in human hepatocellular carcinoma (HCC), the mRNA and/or protein levels of RuvBL1/ pontin and RuvBL2/reptin are increased as compared to non-tumor liver (55)(56)(57)(58)(59)(60). Also, it has been shown that RuvBL1/pontin is overexpressed in breast, colon, and colorectal cancers (61)(62)(63)(64) and RuvBL2/reptin is overexpressed in breast, colon, gastric, and renal cell cancers (62,(65)(66)(67). Additionally, it has been reported that RPAP3 and PIH1D1 expressions are upregulated in breast cancer as well as colon cancer (62,68).…”

Human Tip60 (NuA4) Complex and Cancer

“…Human RuvBL1 and RuvBL2 are overexpressed in a variety of cancers inculding colorectal (Carlson et al, 2003). Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a, (Lauscher et al;2007;Ki et al, 2007), gastric (Li et al, 2010), bladder (Sanchez-Carbayo et al, 2006), mesothelioma (Zhan et al, 2007), non-small cell lung cancer (Dehan et al, 2007), as well as in several types of acute (Andersson et al, 2007) or chronic leukemias (Haslinger et al, 2004), in multiple myeloma (Zhan et al, 2007) and high-grade lymphoma (Nishiu et al, 2002). In ovarian cancer cell lines, microcell-mediated chromosome transfer and expression microarray analysis identified nine genes associated with functional suppression of tumorogenicity; AIFM2, AKTIP, AXIN2, CASP5, FILIP1L, RBBP8, RGC32, RUVBL1 and STAG3.…”

“…These subunits are overexpressed in colon cancer (Yamada and Rao, 2009;Yamaguchi et al,2010Yamaguchi et al, , 2011Carlson et al, 2003;Lauscher et al, 2007;Graudens et al, 2006;Ki et al, 2007). Brd8 plays a role in survival and/or drug resistance of cultured colon cancer cells.…”