Increased Plasma Nitrite Enhances Exercise Performance in PAD:-A Nitric Oxide Effect?

Kenjale, Aarti A.; Ham, Katherine L.; Stäbler, Thomas; Robbins, Jennifer L.; Johnson, Johanna L.; VanBruggen, Mitch; Privette, Grayson; Yim, Eunji; Kraus, William E.; Allen, Jason D.

doi:10.1249/01.mss.0000403025.86280.99

Cited by 2 publications

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“…These observations have implications for improving understanding of the exercise settings in which BR supplementation is more likely to be effective at improving exercise capacity. Specifically, it is possible that BR supplementation is more effective at improving performance at altitude, in individuals with a greater proportion of type II (fast-twitch) skeletal muscle [53,54] and in patients with disorders of skeletal muscle O2 delivery [54,55]. Moreover, since O2peak is an important predictor of all-cause mortality [56]…”

Section: Discussionmentioning

confidence: 99%

Influence of muscle oxygenation and nitrate-rich beetroot juice supplementation on O2 uptake kinetics and exercise tolerance

et al. 2020

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We tested the hypothesis that acute supplementation with nitrate (NO3 -)-rich beetroot juice (BR) would improve quadriceps muscle oxygenation, pulmonary oxygen uptake ( O2) kinetics and exercise tolerance (Tlim) in normoxia and that these improvements would be augmented in hypoxia and attenuated in hyperoxia. In a randomized, double-blind, cross-over study, ten healthy males completed two-step cycle tests to Tlim following acute consumption of 210 mL BR (18.6 mmol NO3 -) and NO3 --depleted beetroot juice placebo (PL; 0.12 mmol NO3 -). These tests were completed in normobaric normoxia [fraction of inspired oxygen content (FIO2): 21%], hypoxia (FIO2: 15%) and hyperoxia (FIO2: 40%). Pulmonary O2 and quadriceps tissue oxygenation index (TOI), derived from multi-channel near-infrared spectroscopy, were measured during all trials. Plasma [nitrite] was higher in all BR compared to all PL trials (P<0.05). Quadriceps TOI was higher in normoxia compared to hypoxia (P<0.05) and higher in hyperoxia compared to hypoxia and normoxia (P<0.05). Tlim was improved after BR compared to PL ingestion in the hypoxic trials (250 ± 44 vs. 231 ± 41 s; P=0.006; d=1.13), with the magnitude of improvement being negatively correlated with quadriceps TOI at Tlim (r

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Section: Discussionmentioning

confidence: 99%

Influence of muscle oxygenation and nitrate-rich beetroot juice supplementation on O2 uptake kinetics and exercise tolerance

et al. 2020

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“…Inorganic nitrate supplementation increases NO bioavailability, via the nitrate-nitrite-NO reduction pathway (32). Nitrate supplementation has been shown to modify exercise capacity in patients with peripheral arterial disease and in some forms of CHF (16,17,34,36). While previous studies demonstrate the efficacy of oral nitrate supplementation to increase exercise capacity in patients with preserved ejection fraction (HFpEF), the potential of the intervention in those with a reduced ejection fraction (HFrEF) is poorly understood due to limited few studies (4,10,17,41).…”

Section: Introductionmentioning

confidence: 99%

Effect of inorganic nitrate on exercise capacity, mitochondria respiration, and vascular function in heart failure with reduced ejection fraction

Woessner

Neil

Saner

et al. 2020

Journal of Applied Physiology

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This is the largest study to date to examine the effects of inorganic nitrate supplementation in patients with heart failure with reduced ejection fraction (HFrEF) and the first to include measures of vascular function and mitochondrial respiration. Although daily supplementation increased plasma nitrite, our data indicate that supplementation with inorganic nitrate as a standalone treatment is ineffective at improving exercise capacity, vascular function, or mitochondrial respiration in patients with HFrEF.

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Increased Plasma Nitrite Enhances Exercise Performance in PAD:-A Nitric Oxide Effect?

Cited by 2 publications

References 0 publications

Influence of muscle oxygenation and nitrate-rich beetroot juice supplementation on O2 uptake kinetics and exercise tolerance

Influence of muscle oxygenation and nitrate-rich beetroot juice supplementation on O2 uptake kinetics and exercise tolerance

Effect of inorganic nitrate on exercise capacity, mitochondria respiration, and vascular function in heart failure with reduced ejection fraction

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