Increased plasma levels of the methylglyoxal in patients with newly diagnosed type 2 diabetes 初诊2型糖尿病患者血浆甲基乙二醛水平升高

Abstract

These findings suggest that increased plasma MG level is associated with the elevation of HbA1c and MDA in newly diagnosed T2DM patients.

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention

“…The reactive dicarbonyls MG [57,58,59,60,61,62], 3DG [58,59,62,63,64] and glyoxal [57,59,60,62] are elevated in serum of diabetic patients alongside blood glucose levels. Protein bound AGEs and AGE free adducts are increased in experimental models of diabetes [18,39,65], and in diabetic patients in parallel with their precursors [66,67].…”

Postprandial Dysmetabolism and Oxidative Stress in Type 2 Diabetes: Pathogenetic Mechanisms and Therapeutic Strategies

“…AGEs have been consistently recognized to accumulate in the blood and tissues of diabetics, in cells isolated from those subjects, and in animal models of diabetes; they may or may not cause vascular complications, although a large body of literature highlights their fundamental role in the development of T2D‐associated vascular dysfunction . As depicted in Figure , these macromolecules and their precursors not only contribute to the induction of an oxidative environment but also directly affect several intra‐ and extracellular processes that impair vascular properties .…”

Methylglyoxal Impairs β₂-Adrenoceptor-Mediated Vasodilatory Mechanisms in Rat Retinal Arterioles

“…It has been reported that plasma concentrations of methylglyoxal in diabetic patients range from 4-400 µM. [7][8][9][10][11] However, the concentrations of methylglyoxal in the vitreous humor and in the retinal tissue have not been previously reported. Therefore, methylglyoxal doses were selected on the basis of the results of studies examining short-term impacts of methylglyoxal.…”

“…[7][8][9][10][11] An accumulation of methylglyoxal in the retina may contribute to the onset and progression of diabetic retinopathy. It has been reported that plasma concentrations of methylglyoxal in diabetic patients range from 4-400 µM.…”

“…6) Plasma levels of methylglyoxal are higher in patients with diabetes (4-400 µM) than in healthy controls (approximately 0.5 µM). [7][8][9][10][11] Excessive methylglyoxal reduces the contractility of isolated blood vessels such as thoracic aorta and superior mesenteric arteries. 12) In the retinal vascular system, methylglyoxal exhibits cytotoxic effects on pericytes by inducing apoptosis through oxidative stress 13) and enhances vascular permeability.…”