Increased plasma levels of CCL20 in peripheral blood of rheumatoid arthritis patients and its association with clinical and laboratory parameters

Pournazari, Mehran; Feizollahi, Parisa; Roghani, Seyed Askar; Assar, Shirin; Soufivand, Parviz; Soleymani, Bijan; Bahrehmand, Fariborz; Kish, Zahra Mohammadi; Taghadosi, Mahdi

doi:10.1007/s10067-021-05899-x

Cited by 7 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CCL20, the exclusive ligand for CCR6, is produced by Th17 cells 30 . More recently, we reported elevated levels of CCL20 in the plasma of newly diagnosed RA patients 10 . Regarding these findings in the newly diagnosed RA patients, it can be concluded that the CCR6‐CCL20 interaction may underpin early pathological events in RA.…”

Section: Discussionmentioning

confidence: 86%

“…30 More recently, we reported elevated levels of CCL20 in the plasma of newly diagnosed RA patients. 10 Regarding these findings in the newly diagnosed RA patients, it can be concluded that the CCR6-CCL20 interaction may underpin early pathological events in RA. The study conducted by Hirota et al (2007) confirmed the importance of CCR6-CCL20 in the pathogenesis of synovitis in animal models.…”

Section: Discussionmentioning

confidence: 93%

“…Multiple chemokines and their receptors, including cysteine–cysteine motif chemokine ligand 2 (CCL2), CCL3, CCL4, CXCL10, CCR1, CCR2, and CCR5, have been implicated in the pathogenesis of RA 7,9 . More recently, we have reported a highly significant elevation in the plasma levels of CCL20 in newly diagnosed RA patients, which was in association with laboratory and clinical parameters of RA 10 . CCL20 mediates its effect by binding to the CCR6, which is mainly expressed by T helper 17 (Th17) cells; cells that not only fulfill a crucial role in protecting the host against fungal and bacterial infections but also in multiple immune‐mediated inflammatory disorders, comprising RA, inflammatory bowel disease, uveitis, multiple sclerosis, asthma, and psoriasis 11–13 .…”

Section: Introductionmentioning

confidence: 90%

See 2 more Smart Citations

Increased gene expression of CCR6 and RORγt in peripheral blood cells of rheumatoid arthritis patients and their correlation with anti‐cyclic citrullinated peptide and disease activity

Roghani,

Lotfi,

Soroush

et al. 2023

Immunity Inflam & Disease

Self Cite

View full text Add to dashboard Cite

ObjectivesThe significance of T helper 17 (Th17) cells in the pathogenesis of rheumatoid arthritis (RA) has recently been demonstrated in many studies. Retinoic acid receptor‐related orphan receptor γt (RORγt) is a transcription factor that is specifically involved in the generation of Th17 cells. Besides, the chemokine receptor CCR6, the receptor for CCL20, is characteristically expressed by these cells. Considering the pivotal roles of Th17 cells in RA pathogenesis, in this study, we assessed the gene expression of CCR6 and RORγt in the peripheral blood leukocytes of new case RA patients. Also, we evaluated their association with anticyclic citrullinated peptide (anti‐CCP) antibodies and disease activity.MethodsForty‐five new case RA patients and 45 healthy persons have been recruited in this investigation. The gene expression of CCR6 and RORγt was evaluated by quantitative real‐time PCR (qRT‐PCR), and anti‐CCP antibodies plasma levels were measured using the enzyme‐linked immunosorbent assay (ELISA) technique. Disease activity was measured according to the disease activity score‐28 (DAS‐28) formula.ResultsThe gene expression of CCR6 and RORγt increased remarkably in new case RA patients compared to healthy controls (p < .05 and p < .01, respectively). Moreover, there was a positive correlation between RORγt gene expression and parameters, including gene expression of CCR6 (p = .001, r = .461), plasma levels of CCL20 (p = .0009, r = .477), ESR (p = .004, r = .419), DAS‐28 (p = .006, r = .402), anti‐CCP (p = .019, r = .346), and RF (p = .001, r = .451). Also, CCR6 gene expression was positively associated with the DAS‐28 (p = .037, r = .310), plasma levels of anti‐CCP (p = .037, r = .312), and ESR (p = .029, r = .327).ConclusionIncreased gene expression of CCR6 and RORγt in peripheral blood leukocytes of new case RA patients may contribute to the exacerbation and pathogenesis of RA.

show abstract

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Increased gene expression of CCR6 and RORγt in peripheral blood cells of rheumatoid arthritis patients and their correlation with anti‐cyclic citrullinated peptide and disease activity

Roghani,

Lotfi,

Soroush

et al. 2023

Immunity Inflam & Disease

Self Cite

View full text Add to dashboard Cite

show abstract

“…Various chemokines are highly expressed in the serum, synovial fluids (SFs), and synovial tissues (STs) of patients with RA compared with those of healthy donors (HD) ( Table 2 ). For instance, the CC-chemokines CCL2, CCL5, CCL11, CCL13, CCL18, CCL19, CCL20, CCL22, CXC-chemokine CXCL2, CXCL5, CXCL8, CXCL9, CXCL10, CXCL11, CXCL12, CXCL13, and CXCL16 were increased in the serum and/or plasma of patients with RA compared with those of HD ( 43 , 44 , 46 , 47 , 54 , 57 , 85 – 90 ).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Chemokines and chemokine receptors as promising targets in rheumatoid arthritis

et al. 2023

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play important roles in RA development and pathogenesis. Biological therapies targeting these cytokines have revolutionized RA therapy. However, approximately 50% of the patients are non-responders to these therapies. Therefore, there is an ongoing need to identify new therapeutic targets and therapies for patients with RA. In this review, we focus on the pathogenic roles of chemokines and their G-protein-coupled receptors (GPCRs) in RA. Inflamed tissues in RA, such as the synovium, highly express various chemokines to promote leukocyte migration, tightly controlled by chemokine ligand-receptor interactions. Because the inhibition of these signaling pathways results in inflammatory response regulation, chemokines and their receptors could be promising targets for RA therapy. The blockade of various chemokines and/or their receptors has yielded prospective results in preclinical trials using animal models of inflammatory arthritis. However, some of these strategies have failed in clinical trials. Nonetheless, some blockades showed promising results in early-phase clinical trials, suggesting that chemokine ligand-receptor interactions remain a promising therapeutic target for RA and other autoimmune diseases.

show abstract

“…Nas doenças reumáticas como Arterite de Takayasu ( 71), e Artrite Reumatóide (72) correlaciona-se diretamente com atividade de doença, inclusive em pacientes com vasculite, com marcadores inflamatórios clássicos normais (PCR e VHS). Para AR, há na literatura científica correlação positiva robusta de níveis de CCL20 com o título de fator reumatóide e anti-CCP, bem como com a pontuação de DAS28 e o valor de VHS (72).…”

Section: Discussionunclassified

Avaliação da imunogenicidade e segurança da vacina fracionada contra febre amarela em pacientes com doenças reumáticas autoimunes com baixo nível de imunossupressão

Proença¹

View full text Add to dashboard Cite

show abstract

Increased plasma levels of CCL20 in peripheral blood of rheumatoid arthritis patients and its association with clinical and laboratory parameters

Cited by 7 publications

References 29 publications

Increased gene expression of CCR6 and RORγt in peripheral blood cells of rheumatoid arthritis patients and their correlation with anti‐cyclic citrullinated peptide and disease activity

Increased gene expression of CCR6 and RORγt in peripheral blood cells of rheumatoid arthritis patients and their correlation with anti‐cyclic citrullinated peptide and disease activity

Chemokines and chemokine receptors as promising targets in rheumatoid arthritis

Avaliação da imunogenicidade e segurança da vacina fracionada contra febre amarela em pacientes com doenças reumáticas autoimunes com baixo nível de imunossupressão

Contact Info

Product

Resources

About