Increased Plasma DPP4 Activity Is Predictive of Prediabetes and Type 2 Diabetes Onset in Chinese Over a Four-Year Period: Result From the China National Diabetes and Metabolic Disorders Study

Abstract

DPP4 activity is an important predictor of the onset of insulin resistance, prediabetes, and type 2 diabetes in apparently healthy Chinese individuals. This finding may have important implications for understanding the etiology of diabetes.

Association of Plasma DPP4 Activity With Mild Cognitive Impairment in Elderly Patients With Type 2 Diabetes: Results From the GDMD Study in China

“…Blood lipids, HbA 1c , IL-6, CRP, nitrotyrosine, and 8-iso-PGF2a were measured as previously described (9,10).…”

“…DPP4 is a widely expressed multifunctional enzyme that exists as a membrane-anchored cellsurface protein or in a soluble form in the plasma (8). Our previous data suggested that increased plasma DPP4 activities were found in type 2 diabetes and promoted the development of hyperglycemia, inflammation, and oxidative stress (9,10). More interestingly, animal studies have proved that DPP4 inhibitors, such as sitagliptin or linagliptin, ameliorated cognitive impairment through suppressing inflammatory reaction or oxidative stress in different models of mice (11,12).…”

Plasma Dipeptidyl Peptidase-4 Activity, a Novel Biomarker or Even a Possible Therapeutic Target for Depression in Type 2 Diabetic Patients: Results from a Cross-Sectional Study in China

“…Dipeptidyl peptidase-4 (DPP4) is a widely expressed multifunctional exopeptidase that exists as a membrane-anchored cell surface protein or in a soluble form in the plasma. In addition to its catalytic function in the degradation of NPY, it has also been identified as a novel adipokine playing important roles in the development of hyperglycemia, inflammation, and oxidative stress [5,6], all of which have been suggested to be involved in the pathogenesis of depression. More importantly, in our previous longitudinal study [5], DPP4 activity was found to be higher in type 2 diabetic patients than in those with normal glucose tolerance.…”

“…In addition to its catalytic function in the degradation of NPY, it has also been identified as a novel adipokine playing important roles in the development of hyperglycemia, inflammation, and oxidative stress [5,6], all of which have been suggested to be involved in the pathogenesis of depression. More importantly, in our previous longitudinal study [5], DPP4 activity was found to be higher in type 2 diabetic patients than in those with normal glucose tolerance. According to these findings above, we speculate that DPP4 activity may be positively correlated with depression symptoms in type 2 diabetes.…”

“…Our data also indicated that the risk of depression increased significantly with higher levels of HbA 1c , IL-6, CPR, nitrotyrosine, and 8-iso-PGF 2a . Increased plasma DPP4 activity has been proved to promote the development of hyperglycemia in our previous study [5]; in addition, it has also been shown to enhance inflammatory response and increase reactive oxygen species generation [7,8,9]. In this study, our results also lent support to a positive association between hyperglycemia, inflammation, oxidative stress and DPP4 activity in type 2 diabetes; moreover, the risk of depression got more pronounced among patients with rising DPP4 activity and higher levels of HbA 1c , IL-6, CRP, nitrotyrosine, and 8-iso-PGF 2a .…”