Increased plasma DPP4 activities predict new-onset atherosclerosis in association with its proinflammatory effects in Chinese over a four year period: A prospective study

Genome-wide analysis reveals adaptation to high altitudes in Tibetan sheep

“…In this study, DPP4 535455, PPARG 5859 and SOD1 61 were associated with energy metabolism. FGFR2 35, NF1 38 and RasGef4 3738 were found in the Ras/ERK signalling pathway, which plays a role in hypoxia, along with the HIF pathway, by promoting angiogenesis.…”

“…In Tibetan sheep, we identified a few genes associated with energy metabolism that were under positive selection. DPP4 is a key enzyme involved in glycolysis, where it degrades GLP-1, which is powered by the hydrolysis of ATP, and plays crucial roles in maintaining glucose stability535455. PPARG , another selected gene, reactivates adipogenesis and transcriptionally activates LPP1 expression, indicating a potential role in the metabolism of phospholipids5657.…”

Dipeptidyl Peptidase-IV Inhibition for the Treatment of Cardiovascular Disease ― Recent Insights Focusing on Angiogenesis and Neovascularization ―

“…59 A small prospective population study also reported that increased plasma DPP-IV levels could be used to predict new-onset atherosclerosis linked to its proinflammatory actions in Chinese individuals even without atherosclerosis over a 4-year follow-up period. 60 We have observed that IHD patients with and without diabetes had higher DPP-IV levels than non-IHD subjects. 61 Our data from a multiple logistic regression analysis demonstrated that plasma DPP-IV activity was an independent predictor of IHD.…”

Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of subclinical atherosclerosis in Chinese patients with newly diagnosed type 2 diabetes: A cross-sectional study

“…Subjects were instructed to maintain their usual physical activity and diet for at least three days before undergoing an oral glucose tolerance test (OGTT). After an overnight fast of ≥10 h, venous blood samples were collected to measure HbA1c, fasting plasma glucose (FPG), fasting insulin, blood lipids Plasma glucose levels, insulin, TC, TG, HDL-C, LDL-C, IL-6, hs-CRP, M6P-R, nitrotyrosine, and 8-iso-PGF2a and c-IMT were measured as previously described [5,6,9,20]. B-mode ultrasonography of the common carotid artery (CCA) was performed using an ultrasound machine (Toshiba; Toshiba Medical Systems, Tokyo, Japan).Each subject was examined in the supine position, with the head elevated ≤45° and a side tilt of 30° to the right and then the same to the left.…”