Increased plasma corin levels in patients with atrial fibrillation

Chen, Feifei; Xia, Yunlong; Liu, Ying; Zhang, Yutao; Song, Wei; Zhong, Yang; Gao, Lianjun; Jin, Yan; Li, Shijun; Yang, Yanzong

doi:10.1016/j.cca.2015.05.017

Cited by 21 publications

(20 citation statements)

References 52 publications

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“…The decreased circulatory levels of Corin could be detected in some cardiovascular diseases such as acute myocardial infarction, heart failure, and stroke [21–27]. Increased serum levels were found in hypertension, obesity, dyslipidemia, hyperglycemia, and atrial fibrillation [28–32]. In the present study, we observed that plasma Corin was negatively associated with the onset of DGF after kidney transplantation.…”

Section: Discussionsupporting

confidence: 57%

Corin Is Downregulated in Renal Ischemia/Reperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation

Lin

et al. 2019

Disease Markers

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Renal ischemia/reperfusion (IR) injury is one of the most important risk factors for the occurrence of delayed graft function (DGF) after kidney transplantation; however, its mechanism remains not fully understood. In the present study, we screened differentially expressed genes in a murine model of renal IR injury by using high-throughput assays. We identified Corin as one of the most significantly downregulated genes among 2218 differentially expressed genes (≥2-fold, P < 0.05). By using a real-time qPCR assay, we observed that the expression of renal Corin in IR-injured mice was reduced to 11.5% of the sham-operated mice and that the protein level of renal Corin in IR-injured mice was also downregulated. Interestingly, renal IR injury in mice induced the downregulation of Corin in heart tissues, suggesting that the overall synthesis of Corin may be suppressed. We recruited 11 recipients complicated with DGF and 16 without DGF, and plasma Corin concentrations were determined by ELISA. We observed that the plasma Corin levels were indeed reduced in recipients complicated with DGF (0.98 vs. 1.95 ng/ml, P < 0.05). These findings demonstrate that Corin may be a potential biomarker of DGF after kidney transplantation and may participate in the regulation of renal IR injury.

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Section: Discussionsupporting

confidence: 57%

Corin Is Downregulated in Renal Ischemia/Reperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation

Lin

et al. 2019

Disease Markers

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“…Besides, the blood (serum or plasma) levels of corin were also found altered under other diseases or pathological conditions. For example, decreased circulating corin has been associated with heart failure [ 15 , 4 ], stroke [ 35 ], non-ST-elevation acute coronary syndrome [ 12 ] whereas increased circulating corin was linked to hyperglycemia [ 36 ], preeclampsia [ 37 ] and atrial fibrillation [ 38 ]. However, key questions remain unanswered to understand the physical meaning of these measurements in patients.…”

Section: Discussionmentioning

confidence: 99%

Increases in plasma corin levels following experimental myocardial infarction reflect the severity of ischemic injury

et al. 2018

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Following acute myocardial infarction, clinical studies show alterations in the blood levels of corin, a cardiac-selective activator of the natriuretic peptides pro-atrial natriuretic peptide (pro-ANP) and pro-B-type natriuretic peptide (pro-BNP). However, the temporal changes in circulating and cardiac corin levels and their relationships to the severity of myocardial infarction have not been studied. The main objective of this study was to examine the relationship between cardiac and circulating corin levels and their association with cardiac systolic function and infarct size during the early phase of acute myocardial infarction (<72 h) in a translationally relevant induced coronary ligation mouse model. This acute phase timeline was chosen to correlate with the clinical practice within which blood samples are collected from myocardial infarction patients. Heart and plasma samples were examined at 3, 24, and 72 hours post acute myocardial infarction. Plasma corin levels were examined by enzyme-linked immunosorbent assay, transcripts of cardiac corin, pro-ANP and pro-BNP by quantitative real-time polymerase chain reaction, cardiac corin expression by immunohistology, infarct size by histology and heart function by echocardiography. Plasma corin levels were significantly increased at 3 (P<0.05), 24 (P<0.001), and 72 hours (P<0.01) post-acute myocardial infarction. In contrast, cardiac corin transcript levels dropped by 5% (P>0.05), 69% (P<0.001) and 65% (P<0.001) and immunoreactive cardiac corin protein levels dropped by 30% (P<0.05), 76% (P<0.001) and 75% (P<0.001), while cardiac pro-ANP and pro-BNP transcript levels showed an opposite pattern. Plasma corin levels were negatively correlated with immunoreactive cardiac corin (P<0.01), ejection fraction (P<0.05) and fractional shortening (P<0.05), but positively correlated with infarct size (P<0.01). In conclusion, acute myocardial infarction induces rapid increases in plasma corin and decreases in cardiac corin levels. In the early phase of acute myocardial infarction, plasma corin levels are inversely correlated with heart function and may reflect the severity of myocardial damage.

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“…In addition, we previously found an increased level of serum soluble corin in patients with some cardio-metabolic factors such as hypertension [ 13 ], dyslipidemia [ 24 ], and obesity [ 14 ]. Serum soluble corin was also found to be increased in patients with atrial fibrillation [ 25 ] but decreased in patients with heart failure [ 12 ] and coronary heart disease [ 26 ]. These factors are also established risk factors of stroke risk and prognosis.…”

Section: Discussionmentioning

confidence: 99%

Serum Soluble Corin Deficiency Predicts Major Disability within 3 Months after Acute Stroke

Chen

Song

et al. 2016

PLoS ONE

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ObjectiveSerum soluble corin has been associated with stroke. However, whether it is associated with stroke prognosis has not yet been studied. Therefore, we aimed to study the association of serum soluble corin with risk of poor outcomes within 3 months after stroke.MethodsWe followed 522 stroke patients for 3 months to identify major disability, death and vascular events. Serum soluble corin was measured at baseline for all participants. Logistic regression was used to examine the associations of baseline serum soluble corin with outcomes of stroke, adjusting for age, sex, baseline NIHSS score, hours from onset to hospitalization, smoking, drinking, hypertension, diabetes, coronary heart disease, atrial fibrillation, family history of stroke, and stroke subtype.ResultsPatients with high corin had a significantly lower crude risk for the composite outcome of major disability or death (OR = 0.64, 95%CI: 0.43–0.96) than patients with low corin (the lowest tertile). After adjustment for age and baseline NIHSS score, patients with high corin still had a significantly lower risk for the composite outcome of major disability or death (OR = 0.60, 95%CI: 0.36–0.99). This association became bottom line significant after additionally adjusting for other conventional factors (OR = 0.61, P = 0.058). No association was found between serum soluble corin and other composite outcomes.ConclusionSerum soluble corin deficiency predicted risk for major disability within 3 months after stroke, independent of baseline neurological deficient. Our results may indicate a probable role of corin in stroke prognosis.

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Increased plasma corin levels in patients with atrial fibrillation

Cited by 21 publications

References 52 publications

Corin Is Downregulated in Renal Ischemia/Reperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation

Corin Is Downregulated in Renal Ischemia/Reperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation

Increases in plasma corin levels following experimental myocardial infarction reflect the severity of ischemic injury

Serum Soluble Corin Deficiency Predicts Major Disability within 3 Months after Acute Stroke

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