Increased Plasma Concentration of Matrix Metalloproteinase-7 in Patients with Coronary Artery Disease

Nilsson, Lennart; Jonasson, Lena; Nijm, Johnny; Hamsten, Anders; Eriksson, Per

doi:10.1373/clinchem.2006.067439

Cited by 38 publications

(41 citation statements)

References 34 publications

(28 reference statements)

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“…25 In the present study, plasma MMP-7 levels demonstrated independent association with prevalent CVD among subjects with T2D. However, the association with atherosclerotic burden was not as pronounced as for MMP-12, and there was no association with the degree of arterial stiffness.…”

Section: Discussioncontrasting

confidence: 63%

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes

Gonçalves

Bengtsson

Colhoun³

et al. 2015

ATVB

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Objective— Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus. Approach and Results— Plasma levels of MMP-1, -3, -7, -10, and -12 were analyzed by the Proximity Extension Assay technology in 1500 subjects participating in the SUMMIT (surrogate markers for micro- and macrovascular hard end points for innovative diabetes tools) study, 384 incident coronary cases, and 409 matched controls in the Malmö Diet and Cancer study and in 205 carotid endarterectomy patients. Plasma MMP-7 and -12 were higher in subjects with type 2 diabetes mellitus, increased with age and impaired renal function, and was independently associated with prevalent cardiovascular disease, atherosclerotic burden (as assessed by carotid intima-media thickness and ankle-brachial pressure index), arterial stiffness, and plaque inflammation. Baseline MMP-7 and -12 levels were increased in Malmö Diet and Cancer subjects who had a coronary event during follow-up. Conclusions— The plasma level of MMP-7 and -12 are elevated in type 2 diabetes mellitus, associated with more severe atherosclerosis and an increased incidence of coronary events. These observations provide clinical support to previous experimental studies, demonstrating a role for these MMPs in plaque development, and suggest that they are potential biomarkers of atherosclerosis burden and cardiovascular disease risk.

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Section: Discussioncontrasting

confidence: 63%

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes

Gonçalves

Bengtsson

Colhoun³

et al. 2015

ATVB

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“…Similarly, plasma concentrations of mmP-3 were 3-fold higher in the control group than in the group of ucad patients. in contrast, mmP-7 concentrations were increased by 50% in unstable cad patients compared to controls (4). Plasma mmP-9 concentration has been identified as a predictor of cardiovascular mortality in patients with cad (5).…”

Section: Introductionmentioning

confidence: 95%

“…in humans, plasma concentrations of different mmPs appear to vary depending on clinical status. for example, we have shown that plasma concentrations of mmP-2 were significantly decreased in patients with unstable coronary artery disease (ucad) compared with patients with stable cad and healthy controls (4). Similarly, plasma concentrations of mmP-3 were 3-fold higher in the control group than in the group of ucad patients.…”

Section: Introductionmentioning

confidence: 99%

MMP-2 and MMP-9 are prominent matrix metalloproteinases during atherosclerosis development in the Ldlr-/-Apob100/100 mouse

Wï¿1⁄2gsï¿1⁄2ter

2011

Int J Mol Med

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Abstract. matrix-degrading proteases capable of degrading components of the extracellular matrix may play an important role in development and progression of atherosclerotic lesions. in the present study, we used the Ldlr -/-Apob 100/100 mouse model, which has a plasma lipoprotein profile similar to that of humans with atherosclerosis, to study the expression of matrix metalloproteinases (mmPs) during early stages of atherosclerosis development. We analyzed the expression of 11 proteases and three protease inhibitors in 5-to 40-week-old Ldlr -/-Apob 100/100 mice. expression and activity of mmP-2 and mmP-9 was increased in advanced atherosclerotic lesions followed by macrophage infiltration as shown by real-time Pcr, gel-based and in situ zymography and immunohistochemistry. expression of other investigated mmPs did not increase during disease progression. However, the mrna expression of mmP-8 and mmP-13 was down-regulated, which could explain the relatively high amount of collagen observed in the vessels in this model. in conclusion, low proteolytic expression at early stages of atherogenesis and a limited repertoire of proteolytic enzymes were associated with the progression of atherosclerosis in Ldlr -/-Apob 100/100 mice. the study suggests that mmP-2 and mmP-9 are the main proteases involved in atherogenesis in this mouse model.

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“…In particular, MMP-7 is involved in N-cadherin cleavage and in vascular smooth muscle cell (VSMC) apoptosis, leading to fibrous cap thickness and to plaque instability . Nonetheless, MMP-7 is increased in patients with stable and unstable coronary artery disease (Nilsson et al, 2006). Furthermore, MMP-7 modulates the transcription of ADAM12, the main protease implicated in cardiac hypertension and hypertrophy ) (see Section 1.1.2): hence, knockdown of MMP-7 results in an attenuation of these pathological conditions.…”

Section: Matrilysinsmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

208

212

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a b s t r a c tHuman matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes.

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Increased Plasma Concentration of Matrix Metalloproteinase-7 in Patients with Coronary Artery Disease

Cited by 38 publications

References 34 publications

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes

MMP-2 and MMP-9 are prominent matrix metalloproteinases during atherosclerosis development in the Ldlr-/-Apob100/100 mouse

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

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