Increased plasma asymmetric dimethylarginine level is associated with ascending aorta dilatation: a case-control study

Satılmışoğlu, Muhammet Hulusi; Diker, Vesile Ornek; Taşbulak, Ömer; Diker, Mustafa; Birand, Ali; Kaya, Mehmet; İyigün, Taner; Eksik, Abdurrahman

doi:10.5603/kp.a2017.0123

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Large-scale epidemiological studies conducted over several years are required to correlate the crosssectional findings from this study with clinical outcomes. The association between AAD and various oxidative stress markers, such as uric acid, gamma-glutamyl transferase, asymmetric dimethylarginine, alpha-1 antitrypsin, C-reactive protein, interleukin-6, and NLR, has previously been shown by different methods in the literature [2,[24][25][26][27][28][29]. Although there was no difference between the groups in terms of NLR in our study population, we did not evaluate all of the oxidative stress parameters.…”

Section: Discussionmentioning

confidence: 67%

Oxidative stress parameters in patients with ascending aortic dilatation

Erdoğan¹,

Polat²,

Çelik³

et al. 2020

Turk J Med Sci

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Background/aim: This study aimed to determine plasma thiol, disulphide, and serum ischemia-modified albumin (IMA) levels and ferroxidase activity in patients with ascending aorta dilatation (AAD) in comparison to those without AAD and to evaluate the predictive value of these oxidative stress parameters for AAD. Materials and methods: This study was designed as a cross-sectional study of 184 patients who applied to our cardiology clinic. Our study population consisted of patients with AAD (n = 85) and without AAD (n = 99). A spectrophotometric method was used to determine plasma thiol, disulphide, and serum IMA levels and ferroxidase activity. Results: The native thiol and the total thiol levels were significantly higher in the control group than the AAD group (P < 0.001), whereas the disulphide and IMA levels and the ferroxidase activity were similar between the groups. The native thiol and the total thiol levels were inversely and significantly correlated with ascending aortic diameter (r =-0.38, P < 0.001; r =-0.39, P < 0.001; respectively). The left ventricle mass and the total thiol levels were independent predictors of ascending aortic diameter (β= 0.223, P = 0.02; β=-0.340, P < 0.001; respectively). Conclusion: Among oxidative stress parameters including thiols, disulphide, IMA, and ferroxidase activity, only the lower total thiol levels appear to confer a high risk for AAD development. Along with the proven diagnostic imaging methods, thiol levels may be helpful to diagnose and stratify patients with AAD.

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Section: Discussionmentioning

confidence: 67%

Oxidative stress parameters in patients with ascending aortic dilatation

Erdoğan¹,

Polat²,

Çelik³

et al. 2020

Turk J Med Sci

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The Predictive Role of Plasma Biomarkers in the Evolution of Aortopathies Associated with Congenital Heart Malformations

Făgărășan

Săsăran

2022

IJMS

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Dilatation of the aorta is a constantly evolving condition that can lead to the ultimate life-threatening event, acute aortic dissection. Recent research has tried to identify quantifiable biomarkers, with both diagnostic and prognostic roles in different aortopathies. Most studies have focused on the bicuspid aortic valve, the most frequent congenital heart disease (CHD), and majorly evolved around matrix metalloproteinases (MMPs). Other candidate biomarkers, such as asymmetric dimethylarginine, soluble receptor for advanced glycation end-products or transforming growth factor beta have also gained a lot of attention recently. Most of the aortic anomalies and dilatation-related studies have reported expression variation of tissular biomarkers. The ultimate goal remains, though, the identification of biomarkers among the serum plasma, with the upregulation of circulating MMP-1, MMP-2, MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1), asymmetric dimethylarginine (ADMA), soluble receptor for advanced glycation end-products (sRAGE) and transforming growth factor beta (TGF-β) being reported in association to several aortopathies and related complications in recent research. These molecules are apparently quantifiable from the early ages and have been linked to several CHDs and hereditary aortopathies. Pediatric data on the matter is still limited, and further studies are warranted to elucidate the role of plasmatic biomarkers in the long term follow-up of potentially evolving congenital aortopathies.

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Increased plasma asymmetric dimethylarginine level is associated with ascending aorta dilatation: a case-control study

Abstract: Serum ADMA level is diagnostic for ascending aorta dilatation with high sensitivity and specificity, and should be considered for use in clinical diagnosis of aorta dilatation.

Cited by 2 publications

References 17 publications

Oxidative stress parameters in patients with ascending aortic dilatation

Oxidative stress parameters in patients with ascending aortic dilatation

The Predictive Role of Plasma Biomarkers in the Evolution of Aortopathies Associated with Congenital Heart Malformations

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