Increased physical activity is not related to markers of cardiometabolic health in two lemur species

Abstract

Insufficient physical activity is a major risk factor for cardiometabolic disease (i.e., unhealthy weight gain, heart disease, and diabetes) in humans and may also negatively affect health of primates in human care. Effects of physical activity on energy expenditure and cardiometabolic health are virtually unstudied in nonhuman primates. We investigated physical activity and metabolic markers in 15 adult ring‐tailed lemurs (Lemur catta) and 11 Coquerel's sifakas (Propithecus coquereli) at the Duke Lemur Center during a period of low activity in winter when the animals were housed in buildings (with outdoor access) and a period of high activity when individuals were free‐ranging in large, outdoor, forested enclosures. We compared body mass, blood glucose, triglycerides, HDL‐ and LDL‐cholesterol, physical activity via accelerometry, and total energy expenditure (TEE) via the doubly labeled water method (in ring‐tailed lemurs only) between both conditions. Both species were more active and had a lower body mass in summer. Ring‐tailed lemurs had a higher TEE and lower triglyceride levels in summer, whereas sifaka had higher triglyceride levels in summer. Individuals that increased their activity more, also lost more body mass. Individuals that lost more body mass, also had a positive change in HDL‐cholesterol (i.e., higher values in summer). Changes in activity were not associated with changes in markers of metabolic health, body fat percentage and TEE (both unadjusted and adjusted for body composition). Older age was associated with lower activity in both species, and decreased glucose in ring‐tailed lemurs, but was otherwise unrelated to metabolic markers and, for ring‐tailed lemurs, adjusted TEE. Overall, body mass was lower during summer but the increase in physical activity did not strongly influence metabolic health or TEE in these populations.