Increased photodynamic therapy sensitization in tumors using a nitric oxide-based nanoplatform with ATP-production blocking capability

Xiang, Qinyanqiu; Qiao, Bin; Luo, Yuanli; Cao, Jin; Fan, Kui; Hu, Xinghua; Lu, Hao; Cao, Yang; Zhang, Qunxia; Wang, Zhigang

doi:10.7150/thno.52997

Cited by 55 publications

(47 citation statements)

References 69 publications

(22 reference statements)

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“…This noninvasive method can discriminate oxygenated hemoglobin from deoxygenated hemoglobin according to the absorbance spectrum. 48 As shown in Figure 4 A , minimal oxyhemoglobin signal intensities were observed in the control and US-only groups, indicating that the US alone could not induce O 2 generation in the tumor microenvironment. In contrast, the Fe-PDAP group showed enhanced oxyhemoglobin signal intensities within the tumor region, confirming that the presence of Fe-PDAP could improve oxygenation in hypoxic tumors via the decomposition of excess H 2 O 2 .…”

Section: Resultsmentioning

confidence: 86%

A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy

Jiang¹,

Qiao²,

Lin³

et al. 2022

Theranostics

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The outcome of sonodynamic immunotherapy is significantly limited by tumor hypoxia. To overcome this obstacle, one common solution is to catalyze the conversion of endogenous H 2 O 2 into O 2 . However, the effectiveness of this strategy is limited by the insufficient concentration of H 2 O 2 in the tumor microenvironment (TME). Herein, we developed a H 2 O 2 economizer for on-demand O 2 supply and sonosensitizer-mediated reactive oxygen species production during ultrasound activation, thereby alleviating hypoxia-associated limitations and augmenting the efficacy of sonodynamic immunotherapy. Methods: The H 2 O 2 economizer is constructed by electrostatic adsorption and π-π interactions between the Fe-doped polydiaminopyridine (Fe-PDAP) nanozyme and chlorin e6. By employing a biomimetic engineering strategy with cancer cell membranes, we addressed the premature leakage issue and increased tumor-site accumulation of nanoparticles (membrane-coated Fe-PDAP/Ce6, MFC). Results: The prepared MFC could significantly attenuate the catalytic activity of Fe-PDAP by reducing their contact with H 2 O 2 . Ultrasound irradiation promoted MFC dissociation and the exposure of Fe-PDAP for a more robust O 2 supply. Moreover, the combination of MFC-enhanced sonodynamic therapy with anti-programmed cell death protein-1 antibody (aPD-1) immune checkpoint blockade induced a strong antitumor response against both primary tumors and distant tumors. Conclusion: This as-prepared H 2 O 2 economizer significantly alleviates tumor hypoxia via reducing H 2 O 2 expenditure and that on-demand oxygen-elevated sonodynamic immunotherapy can effectively combat tumors.

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Section: Resultsmentioning

confidence: 86%

A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy

Jiang¹,

Qiao²,

Lin³

et al. 2022

Theranostics

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“…Although tumors acquire energy predominantly via the “Warburg effect” [ 59 ], seriously accelerated OXPHOS was still observed in considerable malignant cell lines during tumorigenesis, development, and metastasis [ 60 , 61 ]. Consequently, diverse mitochondria respiratory chain inhibitors, including α-tocopherol succinate [ 62 ], papaverine [ 63 ], atovaquone [ 64 , 65 , 66 , 67 , 68 ], tamoxifen [ 69 , 70 ], metformin [ 71 , 72 , 73 , 74 , 75 , 76 , 77 ], and nitric oxide (NO) [ 78 , 79 , 80 , 81 ], have been used for reducing oxygen consumption and increasing PDT efficiency. For example, a nanoplatform was prepared through incorporating L-Arginine and a photosensitizer chlorin e6 with poly-lactic-co-glycolic acid (PLGA) ( Figure 6 ) [ 79 ].…”

Section: Strategies For Modulating Tumor Hypoxia In Pdtmentioning

confidence: 99%

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Liang

Luo

et al. 2022

Biomolecules

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Photodynamic therapy (PDT) is a treatment modality that uses light to target tumors and minimize damage to normal tissues. It offers advantages including high spatiotemporal selectivity, low side effects, and maximal preservation of tissue functions. However, the PDT efficiency is severely impeded by the hypoxic feature of tumors. Moreover, hypoxia may promote tumor metastasis and tumor resistance to multiple therapies. Therefore, addressing tumor hypoxia to improve PDT efficacy has been the focus of antitumor treatment, and research on this theme is continuously emerging. In this review, we summarize state-of-the-art advances in strategies for overcoming hypoxia in tumor PDTs, categorizing them into oxygen-independent phototherapy, oxygen-economizing PDT, and oxygen-supplementing PDT. Moreover, we highlight strategies possessing intriguing advantages such as exceedingly high PDT efficiency and high novelty, analyze the strengths and shortcomings of different methods, and envision the opportunities and challenges for future research.

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“…Chinese herbal medicine has thus proved unique in improving the hypoxic microenvironment and treating EC, but the specific underlying mechanism still requires in-depth analysis. EC can also be treated using phototherapy ( Wang B. et al, 2021 ; Xiang et al, 2021 ). Recently, Liu J. et al (2020) designed a cage-like carbon-manganese nanozyme which can not only improve the hypoxic microenvironment but also deliver a lot of photosensitizers to the tumor site, making it useful for real-time tumor imaging and enhancing the efficacy of phototherapy.…”

Section: Improving the Hypoxic Microenvironmentmentioning

confidence: 99%

Targeting the Microenvironment in Esophageal Cancer

Wang

Han

Wang

et al. 2021

Front. Cell Dev. Biol.

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Esophageal cancer (EC) is the eighth most common type of cancer and the sixth leading cause of cancer-related deaths worldwide. At present, the clinical treatment for EC is based mainly on radical surgery, chemotherapy, and radiotherapy. However, due to the limited efficacy of conventional treatments and the serious adverse reactions, the outcome is still unsatisfactory (the 5-year survival rate for patients is less than 25%). Thus, it is extremely important and urgent to identify new therapeutic targets. The concept of tumor microenvironment (TME) has attracted increased attention since it was proposed. Recent studies have shown that TME is an important therapeutic target for EC. Microenvironment-targeting therapies such as immunotherapy and antiangiogenic therapy have played an indispensable role in prolonging survival and improving the prognosis of patients with EC. In addition, many new drugs and therapies that have been developed to target microenvironment may become treatment options in the future. We summarize the microenvironment of EC and the latest advances in microenvironment-targeting therapies in this review.

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Increased photodynamic therapy sensitization in tumors using a nitric oxide-based nanoplatform with ATP-production blocking capability

Cited by 55 publications

References 69 publications

A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy

A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Targeting the Microenvironment in Esophageal Cancer

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