Increased pain sensitivity is not a risk factor but a consequence of frequent headache: A population-based follow-up study

Buchgreitz, L.; Lyngberg, Ann Christine; Bendtsen, Lars; Jensen, Rigmor

doi:10.1016/j.pain.2007.10.023

Cited by 103 publications

(81 citation statements)

References 32 publications

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“…The current data, however, do not demonstrate an increased risk of future LBP in the group of 'none-orremitted LBP' participants with the lowest PPTs. Thus, the current data suggest that the natural variability in constitutional pain sensitivity does not pose a distinct and separate risk factor for future LBP in itself, which corroborates the findings by Buchgreitz et al [3] on headache sufferers.…”

Section: Lbp Status and Hyperalgesiasupporting

confidence: 91%

“…This question has only been addressed to a lesser extent: The cohort study by Buchgreitz et al [3] examined the changes in cranial muscle pressure pain thresholds (PPTs) over a 12-year period and found that increased pain sensitivity correlated with development of chronic tension type headache. Thus, the authors concluded that increased pain sensitivity of cranial muscles develops as a consequence of chronic headache.…”

Section: Introductionmentioning

confidence: 99%

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Low pressure pain thresholds are associated with, but does not predispose for, low back pain

et al. 2011

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Chronic pain is often associated with hyperalgesia in cross-sectional studies. In the present study, a random cohort of 40-year-old individuals (n = 264) from the general population was assessed for low back pain (LBP) status and pressure pain threshold (PPT), with follow-up assessment 4 and 8 years later. Low PPT at baseline as a potential risk factor for the development of LBP was investigated longitudinally and the association between LBP and hyperalgesia was studied cross-sectionally at baseline and 8-year follow-up. Generalized (p \ 0.03) and localized pressure hyperalgesia (p \ 0.02) was found in participants with long-lasting LBP, but not with recent LBP (p [ 0.08). Of the participants without recent or long-lasting LBP, those with a low PPT at baseline (lower 10% percentile) had no increased risk of developing LBP (p [ 0.05). The findings indicate that PPT decreases as a consequence of long-lasting pain, whereas a low PPT seems not to constitute a separate risk factor for the development of LBP.

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Section: Lbp Status and Hyperalgesiasupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Low pressure pain thresholds are associated with, but does not predispose for, low back pain

et al. 2011

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“…The psychophysical results disprove the central sensitization hypothesis, with the authors stating, "Premorbid PPT [pressure pain thresholds] poorly predict TMD incidence" (Slade et al 2014). Similar negative results are now also reported for development of chronic tension-type headache (Buchgreitz et al 2008), for low back pain (O'Neill et al 2011), and for development of widespread pain (Gupta et al 2007). Thus, there is a large contrast in predictability of chronic pain by brain parameters from that of peripheral sensitivity.…”

Section: The Corticolimbic System As a Predictor And Determinant Of Cmentioning

confidence: 61%

The Emotional Brain as a Predictor and Amplifier of Chronic Pain

et al. 2016

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Human neuroimaging studies and complementary animal experiments now identify the gross elements of the brain involved in the chronification of pain. We briefly review these advances in relation to somatic and orofacial persistent pain conditions. First, we emphasize the importance of reverse translational research for understanding chronic pain-that is, the power of deriving hypotheses directly from human brain imaging of clinical conditions that can be invasively and mechanistically studied in animal models. We then review recent findings demonstrating the importance of the emotional brain (i.e., the corticolimbic system) in the modulation of acute pain and in the prediction and amplification of chronic pain, contrasting this evidence with recent findings regarding the role of central sensitization in pain chronification, especially for orofacial pain. We next elaborate on the corticolimbic circuitry and underlying mechanisms that determine the transition to chronic pain. Given this knowledge, we advance a new mechanistic definition of chronic pain and discuss the clinical implications of this new definition as well as novel therapeutic potentials suggested by these advances.

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“…A number of studies in adults have demonstrated a strong association between headache, cervical and thoracic spine dysfunction (5) and an increased tenderness Table 3. Self-reported painful movements in adolescents without headache, with headache and stratified for type of headache to palpation of pericranial myofascial tissues (25). These studies suggest that increased tenderness is not only observed in TTH (15,16) but also in migraine (6).…”

Section: Discussionmentioning

confidence: 76%

Self-reported muscle pain in adolescents with migraine and tension-type headache

Blaschek

Milde‐Busch²,

Straube

et al. 2012

Cephalalgia

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Aim: To identify possible associations between muscular pain and headache in adolescents in a large population-based sample. Methods: Grammar school students were invited to fill in a questionnaire on headache and associated lifestyle factors. Headache was classified according to the German version of the International Classification of Headache Disorders (2nd edition). Muscular pain was assessed via denoting affected areas in schematic drawings of a body and via provoked muscular pain on controlled movements of head, neck and shoulder regions. Results: Prevalence of any headache within the previous 6 months exceeded 80%. In all subjects muscular pain or pain on movement was most prominent in the neck and shoulder region, ranging from 9% to 27% in the non-headache population to up to 63% for individuals with migraine or mixed migraine and tension-type headache (TTH). Frequency of muscular pain increased significantly with growing chronicity of TTH. Interpretation: A strong association between muscle pain in the neck/shoulder region and headache was observed, pointing to the importance of muscular pain for headache in adolescents. Also, in this age group muscular pain appears to be of particular importance in chronic TTH and -unexpectedly -in migraine, which is the most important new finding in our study.

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Increased pain sensitivity is not a risk factor but a consequence of frequent headache: A population-based follow-up study

Cited by 103 publications

References 32 publications

Low pressure pain thresholds are associated with, but does not predispose for, low back pain

Low pressure pain thresholds are associated with, but does not predispose for, low back pain

The Emotional Brain as a Predictor and Amplifier of Chronic Pain

Self-reported muscle pain in adolescents with migraine and tension-type headache

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