Increased oxidative stress during hyperglycemic cerebral ischemia

Bémeur, Chantal; Ste-Marie, Line; Montgomery, J. A.

doi:10.1016/j.neuint.2007.03.002

Cited by 71 publications

(47 citation statements)

References 161 publications

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“…Besides interference with coagulation and fibrinolysis, hyperglycemia is also associated with an increase in proinflammatory transcription factors and proinflammatory cytokines (Bemeur et al, 2007;Esposito et al, 2002;Garg et al, 2006;Martini and Kent, 2007). In aSAH patients, several studies have linked markers of increased inflammation to the development of DCI (Esposito et al, 2002;Hirashima et al, 1997;Osuka et al, 1998).…”

Section: How Does Hyperglycemia Affect Outcome After Aneurysmal Subarmentioning

confidence: 99%

Hyperglycemia in Aneurysmal Subarachnoid Hemorrhage: A Potentially Modifiable Risk Factor for Poor Outcome

Kruyt

Biessels

DeVries

et al. 2010

J Cereb Blood Flow Metab

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Hyperglycemia after aneurysmal subarachnoid hemorrhage (aSAH) occurs frequently and is associated with delayed cerebral ischemia (DCI) and poor clinical outcome. In this review, we highlight the mechanisms that cause hyperglycemia after aSAH, and we discuss how hyperglycemia may contribute to poor clinical outcome in these patients. As hyperglycemia is potentially modifiable with intensive insulin therapy (IIT), we systematically reviewed the literature on IIT in aSAH patients. In these patients, IIT seems to be difficult to achieve in terms of lowering blood glucose levels substantially without an increased risk of (serious) hypoglycemia. Therefore, before initiating a large-scale randomized trial to investigate the clinical benefit of IIT, phase II studies, possibly with the help of cerebral blood glucose monitoring by microdialysis, will first have to improve this therapy in terms of both safety and adequacy.

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Section: How Does Hyperglycemia Affect Outcome After Aneurysmal Subarmentioning

confidence: 99%

Hyperglycemia in Aneurysmal Subarachnoid Hemorrhage: A Potentially Modifiable Risk Factor for Poor Outcome

Kruyt

Biessels

DeVries

et al. 2010

J Cereb Blood Flow Metab

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“…For example, plasma levels of endothelin-1 (ET-1), a potent vasoconstrictor, are elevated in streptozotocin-induced diabetic rats (Makino and Kamata, 1998) as well as in patients and animal models after ischemic stroke (Barone et al, 1994;Ziv et al, 1992). Hyperglycemia is also associated with increased oxidative stress that exacerbates cerebral injury (Bemeur et al, 2007), possibly due to protein kinase C activation that enhances vasoreactivity in addition to promoting oxidative stress (Cipolla et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Peroxynitrite decreases the effectiveness of NO and interacts with lipids, DNA, and proteins to cause damage to the vasculature (Iadecola, 1997;Maneen et al, 2006). Reactive oxygen and nitrogen species such as superoxide and peroxynitrite are important therapeutic targets for ischemic stroke, especially during hyperglycemia when oxidative stress is high (Bemeur et al, 2007). Thus, another goal of this study was to investigate the role of reactive oxygen and nitrogen species as underlying mechanisms by which MCAO plasma is vasoactive by using pharmacological inhibitors of NAD(P)H oxidase and peroxynitrite.…”

Section: Introductionmentioning

confidence: 99%

Peroxynitrite Decomposition with FeTMPyP Improves Plasma-Induced Vascular Dysfunction and Infarction during Mild but not Severe Hyperglycemic Stroke

Palomares

Gardner‐Morse

Sweet

et al. 2012

J Cereb Blood Flow Metab

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We investigated mechanisms by which circulating factors during hyperglycemic (HG) stroke affect cerebrovascular function and the role of peroxynitrite in stroke outcome. Middle cerebral arteries (MCAs) were isolated from male Wistar rats and perfused with plasma from rats that were hyperglycemic for 5 to 6 days by streptozotocin and underwent either MCA occlusion (HG MCAO) or Sham surgery (HG Sham) compared with MCA perfused with physiologic saline (No plasma). Myogenic responses and endothelial function were compared in untreated MCA (n = 8/group) or with inhibitors of NADPH oxidase (apocynin; n = 8), peroxynitrite (FeTMPyP; n = 8) or endothelin-1 (ET-1) A (BQ-123; n = 8). Finally, animals were treated in vivo before reperfusion after mild ( < 68% cerebral blood flow (CBF) decrease) or severe ( > 68% CBF decrease) MCAO with FeTMPyP (n = 12) or vehicle (n = 12) and CBF and infarction measured. The HG MCAO plasma increased tone in MCA versus No plasma (P < 0.05) that was reversed by FeTMPyP, but not by apocynin or BQ-123. The HG Sham plasma also increased tone in MCA (P < 0.05) that was reversed by BQ-123 only. In vivo, FeTMPyP was neuroprotective during mild, but not severe ischemia. These results show that circulating factors in plasma can affect cerebrovascular function through peroxynitrite generation and ET-1. In addition, peroxynitrite decomposition improves stroke outcome acutely during mild, but not severe HG ischemia.

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“…Hyperglycemia is known to cause endothelial dysfunction and increased oxidative stress in ischemic brain tissue. 26 These may also contribute to changes seen on imaging, though their precise role is yet to be established.…”

Section: Hemichorea-hemiballismus In Non-ketotic Hyperglycemiamentioning

confidence: 99%

Neuroimaging in Patients with Abnormal Blood Glucose Levels

Bathla

Policeni

Agarwal

2013

American Journal of Neuroradiology

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SUMMARY:Smooth neuronal functioning requires an uninterrupted supply of energy that is provided by glucose under normal physiologic conditions. Significant variations in plasma glucose levels, be it hypoglycemia or hyperglycemia, can present with myriad clinical manifestations and may mimic stroke. At times, the diagnosis is either not apparent or not clinically suspected. Imaging can suggest the diagnosis in unsuspected cases and can help in the assessment of the extent of neuronal damage in known cases, making it vital for the neuroradiologist to be aware of both common and atypical neuroimaging findings in hypoglycemia and hyperglycemia.ABBREVIATIONS: GABA ϭ gamma aminobutyric acid; HC-HB ϭ hemichorea-hemiballismus; NIDDM ϭ non-insulin-dependent diabetes mellitus; NKHG ϭ non-

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Increased oxidative stress during hyperglycemic cerebral ischemia

Cited by 71 publications

References 161 publications

Hyperglycemia in Aneurysmal Subarachnoid Hemorrhage: A Potentially Modifiable Risk Factor for Poor Outcome

Hyperglycemia in Aneurysmal Subarachnoid Hemorrhage: A Potentially Modifiable Risk Factor for Poor Outcome

Peroxynitrite Decomposition with FeTMPyP Improves Plasma-Induced Vascular Dysfunction and Infarction during Mild but not Severe Hyperglycemic Stroke

Neuroimaging in Patients with Abnormal Blood Glucose Levels

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