Increased Oxidative DNA Damage in Lean Normoglycemic Offspring of Type 2 Diabetic Patients

Zengi, Ayhan; Ercan, Gülinnaz; Çağlayan, Osman; Tamsel, Sadık; Karadeniz, Muhammed; Şimşir, Ilgın Yıldırım; Harman, Ece; Kahraman, Cemil; Orman, Mehmet; Çetinkalp, Şevki; Ozgen, Gokhan

doi:10.1055/s-0031-1275289

Cited by 25 publications

(22 citation statements)

References 26 publications

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“…Oxidative stress is the pathogenic constituent in diabetic endothelial dysfunction. Moreover, overweight and obesity may induce oxidative stress too [22]. In our study, all subjects had overweight, but only MPO and SOD enzymes in subjects with IR and without IR were different.…”

Section: Discussionmentioning

confidence: 57%

Myeloperoxidase Is Associated with Insulin Resistance and Inflammation in Overweight Subjects with First-Degree Relatives with Type 2 Diabetes Mellitus

et al. 2015

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BackgroundFamily history of type 2 diabetes mellitus (T2DM) is one of risk factors for that in future a subject can develop diabetes. Insulin resistance (IR) is important in the pathogenesis of T2DM. There is evidence that oxidative stress plays an important role in the etiology and/or progression of diabetes. Myeloperoxidase (MPO) participates in developing of inflammation. The objective was to investigate if MPO is associated with IR and inflammation in individuals with first-degree relatives of T2DM.MethodsCross-sectional study in 84 overweight individuals with family history of T2DM divided in two groups according to IR, group with IR (homeostasis model assessment [HOMA] ≥2.5; n=43) and control group (CG; HOMA <2.5; n=41). Complete clinical history and a venous blood sample were collected for measuring glucose and lipids profile, insulin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), MPO, glutathione reductase (GRd), glutathione peroxidase, and superoxide dismutase.ResultsMPO, TNF-α, and IL-6 were higher in patients with IR than in CG (MPO: 308.35 [190.85 to 445.42] vs. 177.35 [104.50 to 279.85], P=0.0001; TNF-α: 13.46 [10.58 to 18.88] vs. 9.39 [7.53 to 11.25], P=0.0001; IL-6: 32.93 [24.93 to 38.27] vs. 15.60 [12.93 to 26.27]; P=0.0001, respectively). MPO was associated with IR (rho de Spearman=0.362, P=0.001). In the analysis of lineal regression, MPO predicts IR (β, 0.263; t, 2.520; P=0.014). In the univariate analysis, MPO had an odds ratio of 9.880 for risk of IR (95% confidence interval, 2.647 to 36.879).ConclusionMPO had relation with IR and inflammation parameters in overweight subjects with first-degree relatives of T2DM. We need studies on a casual relationship and molecular mechanisms among the increased serum MPO levels, inflammation markers, and IR.

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Section: Discussionmentioning

confidence: 57%

Myeloperoxidase Is Associated with Insulin Resistance and Inflammation in Overweight Subjects with First-Degree Relatives with Type 2 Diabetes Mellitus

et al. 2015

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“…Larger cohort studies are required to determine the influence of duration of IFG that can lead to oxidative DNA damage by determining the activity of additional oxidative stress and inflammatory markers including catalase enzyme activity and protein oxidation as well as NADPH. 34,35 Conclusion We propose that preclinical atherosclerosis is associated with raised BGL (below 6.1 mmol/l), normal cholesterol with no significant lipid peroxidation but an increased TG level, which results in increased 8-OHdG but normal GSH. Medications such as antihypertensive medication or statins do not protect endothelial cells from free-radical damage in our model.…”

Section: Discussionmentioning

confidence: 83%

Oxidative stress and triglycerides as predictors of subclinical atherosclerosis in prediabetes

Al-Aubaidy

Jelinek²

2014

Redox Report

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“…ROS if not controlled by antioxidant systems can affect mitochondrial function, DNA integrity, and protein folding that result in cell death [121,123,129,134–138]. Studies have associated oxygen free radical production with DNA damage in diabetic patients [139,140], mitochondrial injury and aging mechanisms [137,141,142], and nutritional impairment [143]. …”

Section: Epo Oxidative Stress and Apoptosismentioning

confidence: 99%

Erythropoietin: New Directions for the Nervous System

Maiese

Chong

Shang

et al. 2012

IJMS

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New treatment strategies with erythropoietin (EPO) offer exciting opportunities to prevent the onset and progression of neurodegenerative disorders that currently lack effective therapy and can progress to devastating disability in patients. EPO and its receptor are present in multiple systems of the body and can impact disease progression in the nervous, vascular, and immune systems that ultimately affect disorders such as Alzheimer’s disease, Parkinson’s disease, retinal injury, stroke, and demyelinating disease. EPO relies upon wingless signaling with Wnt1 and an intimate relationship with the pathways of phosphoinositide 3-kinase (PI 3-K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR). Modulation of these pathways by EPO can govern the apoptotic cascade to control β-catenin, glycogen synthase kinase-3β, mitochondrial permeability, cytochrome c release, and caspase activation. Yet, EPO and each of these downstream pathways require precise biological modulation to avert complications associated with the vascular system, tumorigenesis, and progression of nervous system disorders. Further understanding of the intimate and complex relationship of EPO and the signaling pathways of Wnt, PI 3-K, Akt, and mTOR are critical for the effective clinical translation of these cell pathways into robust treatments for neurodegenerative disorders.

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Increased Oxidative DNA Damage in Lean Normoglycemic Offspring of Type 2 Diabetic Patients

Cited by 25 publications

References 26 publications

Myeloperoxidase Is Associated with Insulin Resistance and Inflammation in Overweight Subjects with First-Degree Relatives with Type 2 Diabetes Mellitus

Myeloperoxidase Is Associated with Insulin Resistance and Inflammation in Overweight Subjects with First-Degree Relatives with Type 2 Diabetes Mellitus

Oxidative stress and triglycerides as predictors of subclinical atherosclerosis in prediabetes

Erythropoietin: New Directions for the Nervous System

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