Increased osteoprotegerin levels in women with previous gestational diabetes developing metabolic syndrome

A comparison of osteoprotegerin with adiponectin and high-sensitivity C-reactive protein (hsCRP) as a marker for insulin resistance

“…The absence of a significant relationship between OPG and HOMA-IR is in contrast to a number of other studies [10,[13][14][15] which consisted of patients with relatively high levels of IR -including patients with type 2 diabetes [13,14] or a previous history of gestational diabetes [10]. In a group of 106 obese patients (18 with type 2 diabetes), Gannage-Yared et al found a positive association between OPG and HOMA-IR (r =0.295, P < .01) [13].…”

“…In a study by Yaturu et al [14] there was a significant but weak positive correlation between OPG and HOMA-IR (r =0.22, P < .05). Akinci et al found higher OPG in women with a history of gestational diabetes mellitus (GDM) and current metabolic syndrome (MS) but not diabetes compared to those with a history of GDM but no current MS and normal controls [10]. In the group as a whole, there was a weak but statistically significant relationship between OPG and HOMA-IR (r = 0.146, P = .04).…”

“…Although IR is a key feature of the cardiometabolic syndrome in which diabetes and cardiovascular disease often co-exist, the relationship between serum OPG and IR remains unclear. A positive correlation between OPG and hsCRP has been demonstrated in a number of studies [9,10], but inconsistent relationships between OPG and adiponectin have been described.…”

Osteoprotegerin is independently associated with metabolic syndrome and microvascular complications in type 2 diabetes mellitus

“…While no correlation between OPG and MS was seen in a populationbased study in postmenopausal women, 4 higher OPG levels were associated with MS in younger women with previous gestational diabetes. 8 OPG expression is inhibited by insulin administration. 9 As insulin resistance is strongly associated with the development of MS, it is likely insulin resistance may contribute to elevated OPG.…”

Insulin Need in Gestational Diabetes is Associated with a Worse Cardiovascular Risk Profile after Pregnancy

“…Babies born to mothers with GDM are also at increased risk for neonatal hypoglycemia and hyperbilirubinemia (1,2). In addition, women with previous GDM are at an increased risk of developing type 2 diabetes mellitus (3,4), cardiovascular disorders, hypertension, dyslipidemia and metabolic syndrome (4)(5)(6)(7)(8).…”