Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus

Kim, Jae Shin; Kook, Jae; Lee, Jung Seok; Choi, Seong‐Ho; Cho, Kyoo-Sung

doi:10.5051/jpis.2016.46.5.350

Cited by 6 publications

(4 citation statements)

References 21 publications

(32 reference statements)

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“…), ACS (Choi, Lee, Kim, Kim & Choi, ) and BCP (Choi et al., ; Kim, Cha, et al. ; Kim, Cha, Lee, Choi & Cho, ). Moreover, bMSCs modified with AdBMP‐2 and combined with different scaffolds promoted significantly more new bone formation in the rabbit maxillary sinus compared to sites where AdBMP‐2 was not employed (Jiang, Sun, Lai, Zhao & Wang, ; Sun, Xia, Chou, Zhong & Zhang, ).…”

Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

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Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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“…However, this study spanned only eight weeks, so more research is needed to investigate how bone derived by grafting changes over time. It will also be necessary to examine concentration-dependent bone formation by BMP-2 in order to find the most effective dose [8,26]. Manipulating the composition of BC could generate new material that is even safer and more effective in the long term.…”

Section: Discussionmentioning

confidence: 99%

“…A stock human-derived recombinant BMP-2 (rhBMP-2) solution (1.0 µg/µL) (Osteogenetics GmbH, Würzburg, Germany) was diluted to 0.5 μg/μL with sterilized distilled water (Otsuka distilled water, Otsuka Pharmaceutical, Tokyo, Japan) [26].…”

Section: Methodsmentioning

confidence: 99%

Efficacy of Bacterial Cellulose as a Carrier of BMP-2 for Bone Regeneration in a Rabbit Frontal Sinus Model

et al. 2019

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If the alveolar bone height of patients requiring dental implants in the maxillary molar region is inadequate, it is difficult to achieve satisfactory outcomes using existing bone graft materials. We previously reported the possible utility of bacterial cellulose (BC) as a new dental treatment material. BC has a high absorptive capacity, good mechanical strength, and good volume retention. BC loaded with bone morphogenetic protein-2 (BMP-2) might allow effective alveolar bone augmentation. We created critical frontal bone defect models in 12 male Japanese white rabbits and divided them into four groups: sham; BC (BC grafting only); BMP-2 (treated with BMP-2 solution only); and BC+BMP-2 (grafted with BC loaded with BMP-2). Newly formed bone volume was calculated via hematoxylin-eosin staining evaluation. The proliferating cell nuclear antigen and osteocalcin levels were determined by the immunohistochemical staining analysis. All measured indices of the BC+BMP-2 group were significantly superior to those of the other groups (all p < 0.05). BC maintained the graft space and released BMP-2 in a sustained manner, promoting optimal bone formation. The BC+BMP-2 combination enhanced bone regeneration and shows promise as a useful means of clinical pre-dental implant bone augmentation in the maxillary sinus.

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“…Regarding the dosage of BMPs, the combination of BCP with a high concentration of rhBMP-2 (1.5 mg/ml) has proved to inhibit bone regeneration from pristine bone and increase the inflammatory response in the early stages in animal models [169] . Meanwhile, a low dosage of rhBMP-2 (0.05 mg/ml) in a BCP carrier has been shown to promote an osteoinductive effect with accelerated mineralization in animal models [170] . Moreover, it has been reported that a combination of BCP with 0.5 mg/ml of rhBMP-2 formed a greater volume of bone in a rabbit model than BCP combined with 1.0 mg/ml of rhBMP-2 [171] .…”

Section: Delivery Systems For Bmps In Bone Regenerationmentioning

confidence: 99%