Increased osteoblast functions on theta+delta nanofiber alumina

Webster, Thomas J.; Hellenmeyer, Elaine L.; Price, Rachel L.

doi:10.1016/j.biomaterials.2004.03.040

Cited by 137 publications

(85 citation statements)

References 28 publications

(52 reference statements)

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“…liskova et al the properties of natural tissues, 8,9 and so they should support cell adhesion, proliferation, and differentiation. In addition, NCD wettability can be tailored by grafting specific atoms and functional chemical groups (eg, oxygen, hydrogen, amine groups) that influence the wettability and surface energy of NCD films.…”

mentioning

confidence: 99%

Osteogenic cell differentiation on H-terminated and O-terminated nanocrystalline diamond films

Lišková¹,

Babchenko²,

Varga³

et al. 2015

IJN

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Nanocrystalline diamond (NCD) films are promising materials for bone implant coatings because of their biocompatibility, chemical resistance, and mechanical hardness. Moreover, NCD wettability can be tailored by grafting specific atoms. The NCD films used in this study were grown on silicon substrates by microwave plasma-enhanced chemical vapor deposition and grafted by hydrogen atoms (H-termination) or oxygen atoms (O-termination). Human osteoblast-like Saos-2 cells were used for biological studies on H-terminated and O-terminated NCD films. The adhesion, growth, and subsequent differentiation of the osteoblasts on NCD films were examined, and the extracellular matrix production and composition were quantified. The osteoblasts that had been cultivated on the O-terminated NCD films exhibited a higher growth rate than those grown on the H-terminated NCD films. The mature collagen fibers were detected in Saos-2 cells on both the H-terminated and O-terminated NCD films; however, the quantity of total collagen in the extracellular matrix was higher on the O-terminated NCD films, as were the amounts of calcium deposition and alkaline phosphatase activity. Nevertheless, the expression of genes for osteogenic markers – type I collagen, alkaline phosphatase, and osteocalcin – was either comparable on the H-terminated and O-terminated films or even lower on the O-terminated films. In conclusion, the higher wettability of the O-terminated NCD films is promising for adhesion and growth of osteoblasts. In addition, the O-terminated surface also seems to support the deposition of extracellular matrix proteins and extracellular matrix mineralization, and this is promising for better osteoconductivity of potential bone implant coatings.

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mentioning

confidence: 99%

Osteogenic cell differentiation on H-terminated and O-terminated nanocrystalline diamond films

Lišková¹,

Babchenko²,

Varga³

et al. 2015

IJN

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“…Nanocerâmicas, incluindo óxido de zinco, titânio e alumina, apresentaram bons resultados para a regeneração de tecidos ósseos e cartilagem, por exemplo, a adesão de osteoblastos aumentou de 146% a 200%, quando avaliado nanofase de óxido de zinco (23 nm) e de titânio (32 nm) em comparação com microfase de óxido de zinco (4,9 µm) e de titânio (4,1 µm), respectivamente (COLON et al, 2006). Também foi observado aumento da síntese de colágeno; e, em particular, as nanofibras de alumina aumentaram a síntese de colágeno, a atividade da fosfatase alcalina e a deposição de cálcio mineral pelos osteoblastos (WEBSTER et al, 2005).…”

Section: Nanotecnologia E Saúdeunclassified

Nanobiotecnologia: plataforma tecnológica para biomateriais e aplicação biológica de nanoestruturas

Faria-Tischer

Tischer

2012

Biochem. Biotechnol. Rep.

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Nanobiotecnologia: plataforma tecnológica para biomateriais e aplicação biológica de nanoestruturasAbreviaturas: Nanobiotechnology, biomaterials and biological application of nanostructures Nanobiotecnologia, biomateriais e aplicação biológica de nanoestruturas ResumoA nanotecnologia é um campo da ciência que tem se desenvolvido de maneira impressionante, juntamente com a biotecnologia, misturando o conhecimento da ciência dos materiais e da química com os da biologia. Este artigo de revisão busca unir o conhecimento em biomateriais, como carboidratos e proteínas, com aqueles sobre nanopartículas, sistemas auto-organizados, nanofilmes, nanoemulsões e nanoestruturas, para encapsulação de compostos ativos. O impacto econômico dos produtos de nanotecnologia está na ordem dos trilhões de dólares. A nanobiotecnologia divide uma grande parte desse mercado. Os setores que alcançam benefícios com o desenvolvimento de produtos, técnicas, metodologias e processos em escala nanométrica são: saúde, alimentos e agroindústria. Este representa um campo fértil para aplicações em grande volume. A nanobiotecnologia é uma realidade e o conhecimento de biomateriais, das ciências biológicas e da engenharia, através da união de diferentes grupos de pesquisa em seus campos específicos, permite a concepção de produtos nunca imaginados há alguns anos. Palavras AbstRActNanotechnology is a science field that has been developping amazingly together with the biotechnology, mixing the knowledge of material science and chemistry with the biology. This review article links the know-how of biomaterials in the recent years, like carbohydrates and proteins with those about nananoparticles, self-assembled systems, nanofilms, nanoemulsions and nanoestructures for active compounds for encapsulation. The economical impact of nanotech products is in order of trillions of US dollars, and nanobiotechnology has a great share of this market. The sectors that have benefits with the development of products, technics, methodology and processes on nanometric scale are the health, food and agroindustry. The last one represents a fertile field for applications on a large scale. The nanobiotechnology is a reality and the knowledge of biomateriais, biological sciences and engineering, through the union of different research groups on their specific fields, allows the conception of products never considered many years ago.

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“…Conventional titania possessed an exclusively rutile phase, while nanophase titania was a mixture of anatase and rutile [124]. Since ceramic crystal structure as well as surface roughness promotes osteoblast function [125], nanophase titania can improve bone formation.…”

Section: Biochemistrymentioning

confidence: 99%

Nanofeatured Titanium Surfaces for Dental Implantology: Biological Effects, Biocompatibility, and Safety

Baena

Rizzo

Manzo

et al. 2017

Journal of Nanomaterials

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Nanotechnology enables the control and modification of the chemical and topographical characteristics of materials of size less than 100 nm, down to 10 nm. The goal of this review is to discuss the role of titanium substrates as nanoscale surface modification tools for improving various aspects of implantology, including osseointegration and antibacterial properties. Techniques that can impart nanoscale topographical features to endosseous implants are described. Since the advent of nanotechnology, cellular specific functions, such as adhesion, proliferation, and differentiation, have been better understood. By applying these technologies, it is possible to direct cellular responses and improve osseointegration. Conversely, modulating surface features by nanotechnology could have the effect of decreased bacterial colonization.

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Increased osteoblast functions on theta+delta nanofiber alumina

Cited by 137 publications

References 28 publications

Osteogenic cell differentiation on H-terminated and O-terminated nanocrystalline diamond films

Osteogenic cell differentiation on H-terminated and O-terminated nanocrystalline diamond films

Nanobiotecnologia: plataforma tecnológica para biomateriais e aplicação biológica de nanoestruturas

Nanofeatured Titanium Surfaces for Dental Implantology: Biological Effects, Biocompatibility, and Safety

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